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Vitamin D. Basic Research and its Clinical Application
Proceedings of the Fourth Workshop on Vitamin D, Berlin, West Germany, February 1979
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Edited by:
A. W. Norman
, K. Schaefer , D. v. Herrath , H.-G. Grigoleit , J. W. Coburn , H. F. De Luca , E. B. Mawer and T. Suda
Language:
English
Published/Copyright:
1979
Topics
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Frontmatter
I -
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Foreword
V -
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Contents
IX - Chemistry, Structure, Function and Biological Assay
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Introduction
1 -
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Synthesis of Some Side Chain Analogues of Vitamin D3 Metabolites
13 -
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Structural Transformations on Vitamin D
21 -
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Distribution and Activity of a Vitamin D3 Compound in Trisetum Flavescens
33 -
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Synthesis and Biological Activity of 24R-Hydroxy-25-fluorocholecalciferol and 1a, 24R-Dihydroxy-25-fluorocholecalciferol
37 -
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The Synthesis and Biological Evaluation of Fluorinated Analoges as Probes of Vitamin Da Metabolism
45 -
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19-Substituted-10,19-Dihydrovitamins via Hydrozirconation of Vitamin D3
51 -
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The Synthesis of 1a, 3a-Dihydroxy-25Methylcholesta-5,7-Diene-24-OIC Acid, and of la, 3a-Dihydroxy-25 Methylcholesta-5,7-Diene
55 -
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Interconversion of Vitamin D and Trans-Vitamin D by Triplet-Sensitized Isomerization
61 -
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The Use of UV, CD, 2H-NMR Spectroscopy and Mass Spectrometry for the Investigation of Conformational Mobility of Vitamin D and Previtamin D and their Interconversion
65 -
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25 (R), 26 and 25 (S), 26-(OH)2D3: Biological Activity in Intact and Nephrectomized Rats. Comparative Effects of 1, 25, 24 (R), 25-(OH)2D3 and I, 24 (R), 25-(OH)3D3
73 -
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Inhibitors of Vitamin D Metabolism and Action
77 -
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C(1)-Hydroxylation of Vitamin D3 and Related Compounds
81 -
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Vitamin D3 Sulfate in Lactating normally fed Rats and Suckling Pups After Maternal Administration of 3H Vitamin D3 or 35S Vitamin D3 Sulfate
85 -
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Synthesis of Vitamin D Analogues and their Covalent Binding to Affinity Chromatographic Media
89 - Osteoporosis
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Calcium Absorption and Plasma 1,25 (OH)2D Levels in Post-Menopausal Osteoporosis
99 -
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Osteoporosis and Age-Related Osteopenia: Evaluation of Possible Role of Vitamin D Endocrine System in Pathogenesis of Intestinal Calcium Absorption
107 -
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Two Years Experience of Oral Treatment with 1a-Hydroxyvitamin D and Calcium in Patients with Senile or Postmenopausal Osteoporosis
115 -
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The Treatment of Osteoporosis with 24,25 Dihydroxycholecalciferol A Pilot Study
119 -
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Osteomalacic Factors in the Osteoporosis and the Treatment of Osteoporotic Patients with Vitamin D2 and 1aOHD3
123 - Transcalciferan/D-Binding Protein(s)
-
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Biologic Significance of Genetic Variation in Human Gc (Vitamin D-Binding Protein)
129 -
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The Transport of Vitamin D
137 -
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Structure and Properties of Human Plasma Vitamin D Transport Protein (Group-Specific Component)
149 -
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Serum Vitamin D Binding and Gc Polymorphism
153 - Sunlight, Skin and Seasonal Effects
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Identification of in Vivo Generated Previtamin D3, Vitamin D3 and 25-Hydroxyvitamin D3 in the Vitamin D-Deficient Rats Irradiated by Ultraviolet Light
159 -
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Response of Plasma 250HD to Standardized Ultra Violet Radiation
163 -
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Effects of Sunlight Exposure on Blood Concentration of Vitamin D Derivatives in Healthy Japanese Adults
165 -
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Contribution of Skin Vitamin D3 Synthesis in Patients Receiving Total Parenteral Nutrition
169 -
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The Photo-Biochemistry of Vitamin D3 in Vivo in the Skin
173 - Assays for Vitamin D Metabolites
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Measurement of Plasma 1,25 (OH)2 Vitamin D by Protein Binding Assay and Radioimmunoassay
179 -
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Use of Isotope Dilution Mass Fragmentography in Vitamin D Research
183 -
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Assay of 1,25-Dihydroxyvitamin D and Other Active Vitamin D Metabolites in Serum: Application to Animals and Humans
189 -
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24,25-Dihydoxyvitamin D in Human Serum
197 -
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Radioimmunoassay of Vitamin D Metabolites
205 -
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Assays for Vitamin D and its Metabolites
213 -
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Radioimmunoassay for Circulating 1,25- and 25,26-Dihydroxycholecaliferols in Man
221 -
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Hemisuccinates of Vitamin D3 and of its Metabolites
229 -
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Studies on Antisera against Vitamin D Metabolites
233 -
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The Measurement of Various Vitamin D Derivatives in Plasma Using High-Pressure Liquid Chromatography
239 -
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Assay of 1,25- and 24,25 Dihydoxycholecalciferol in Human Serum - some Technical Considerations
243 -
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Radiocompetitive Protein Binding Assays for 25-Hydroxy Vitamin D, 24,25-Dihydroxyvitamin D and 1,25-Dihydroxy-vitamin D in Human Serum
247 -
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Steroid Receptors: What do We not Know?
251 - Vitamin D - Parathyroid Hormone
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Cholecalcifediol suppression of PTH Secretion from Monolayer Culture of Human Parathyroid Carcinoma Cells
261 -
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The Effect of Human Growth Hormone Replacement on Parathyroid Function and Vitamin D Metabolism
265 -
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Serum Calcium Concentration: Possible Regulator of Renal Parathyroid Hormone Action
267 -
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Effects of Vitamin D3 Metabolites Injection into Thyro-parathyroidectomized Pregnant Rats on Fetal Weight and Liver Glycogen Stores in Mothers and Fetuses
271 -
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Effects of Vitamin Deficiency on Calcium-Binding Proteins and on Plasma Calcitonin and Parathyroid Hormone Levels in Growing Pigs
275 -
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1,25 Dihydroxycholecalciferol effect on in Vitro Immunoreactive Human Parathyroid Hormone Secretion from Hyperplastic Glands
279 -
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Quantitative Changes of Rat Thyroid C Cell Population in Hyper- and Hypovitaminosis D
285 -
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The Interactions Between Vitamin D Metabolites, Parathyroid Hormone and Calcitonin
289 -
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In Vivo Suppression of Parathyroid Hormone Secretion by 24,25 Dihydroxy Cholecalciferol in Hyperparathyroid Dogs
297 - Renal Actions
-
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Acute and Chronic Effects of Vitamin D Metabolites on the Renal Handling of Phosphate
307 -
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Interaction of Vitamin D Metabolites with Parathyroid Hormone and Vasopressin
315 -
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Phosphaturie Effect of Parathyroid Hormone in Phosphate Depleted Man
325 - Vitamin D in Maternal, Fetal and Neonatal Conditions
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Long Term Effects of Low 25-Hydroxyvitamin D (25-OHD) Serum Concentrations in Premature infants: A Preliminary Report
331 -
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Vitamin D, Calcium and Phosphorus Requirements and Bone Mineralization in Preterm Infants
335 -
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The Transplacental Movement of Metabolites of Vitamin D in the Sheep
341 -
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The Effects of Solanum Glaucophyllum Ingestion by Pregnant Cows on Plasma Calcium Levels in Dams, Fetuses and Neonates and on the Mineral Composition of Colostrum
345 -
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The Vitamin D3 Requirement for Premature Infants
349 -
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Calcium Uptake and Binding by Membrane Fractions of Human Placenta: ATP Dependent Calcium Accumulation
353 - Skeletal Actions
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Influence of 1,25(OH)2D3 on Bone Surface Lining Cells and on cartilage mineralisation in vitro. Ultrastructural studies
359 -
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The Role of Vitamin D Metabolites in Calcification of Chicken Epiphysis
363 -
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Bone Mineral Solubility and its Alteration by 1,25-Dihydroxyvitamin D3
369 -
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Accelerated Bone Formation in End Stage Renal Disease
373 -
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24,25-Dihydroxyvitamin D: The Preferred Metabolite for Bone
381 -
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Cellular Location and Regulation of the 24,25-Dihydroxyvitamin D3 Formation in Cultured Cells from Bone and Cartilage
391 -
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Comparison of the Histological Effect and Metabolism of 25-(OH)D and 1,25-(OH)2D in Rat Bone
399 -
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Action of Solanum Malacoxylon on Bone Histology of Vitamin D Deficient Rats
403 -
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Dual Action of Parathyroid Hormone on the Mineralization of Rat Incisor Dentin
411 -
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Influence of Diet on the Response of Bone Cells to 1,25-OH)2D3 in Thyroparathyroidectomized Rats
415 -
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Nuclear Binding of 24,25-(OH)2D3 and its Effect on DNA Polymerase Activities in Cultured Chondrocytes
419 -
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Effects and Interaction of 1,25 (OH)2Ds and 24,25 (OH)2D3 on Bone
425 -
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Effects on Mineral Homeostasis of 1,25 (OH)2D3 and 24,25 (OH)2D3, Alone and in Combination, in Rats
429 -
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Effect of Dihydroxylated Vitamin D Metabolites on Experimental Rickets
431 -
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Evidence for the Presence of 25-OH-D3 Binding Proteins in Embryonic Cartilage
435 -
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Glucocorticoid Dependence of Cytosol 1,25-Dihydroxycholecalciferol Receptors in Fetal Rat Calvaria
439 - Vitamin D Metabolism
-
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Recent Developments in the Metabolism of Vitamin D
445 -
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The Role of Systemic PH in the Bioactivation of Vitamin D
459 -
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The Site of Synthesis of 1,25(OH)2 Vitamin D3 in the Kidney A Microenzymatic Assay on Isolated Tubules
463 -
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Response of Chick Kidney Cell Cultures to 1,25-Dihydroxyvitamin D3
467 -
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Growth Hormone and Prolactin Action on Vitamin D Metabolism in the Rat
475 -
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Effective Liver 25-Hydroxylation of Vitamin D under Chronic Ethanol Administration in the Rat
479 -
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Calcium Transport by Rat Colon: Response to 1a,25(OH)2D3 and Dietary Calcium Restriction
483 -
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Direct Vitamin D3-Metabolite Regulation of Kidney 25-Hydroxyvitamin D3 Metabolism
493 -
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The Regulation of 25-Hydroxylation by Vitamin D Intake in Man: A Theoretical Model
497 -
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Minimal Deprivation of Vitamin D Enables Parathyroid Hormone to Stimulate 25-OH Vitamin D - 1a-Hydroxylase
501 -
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Vitamin D Metabolism in Japanese Quail: Effects of Lead Exposure and Dietary Calcium
503 -
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Evidence for a Calcium-Dependent, PTH-lndependent Regulation of Plasma 1,25-Dihydroxyvitamin D in Rats
511 -
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Computer Modeling of Vitamin Metabolism
515 -
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Prolactin, Growth Hormone and Vitamin D Metabolism
523 -
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A Study of the Physiologic Significance of 24-Hydroxylation of 25-Hydroxyvitamin D
531 -
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Dynamic Aspects of Vitamin D Metabolism: Formation of Hydroxylated Metabolites from A Physiological Dose of Cholecalciferol in Vitamin D Depleted Man
537 -
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The Regulation of Plasma 1,25-(OH)2-D Concentrations in Healthy Adults
545 -
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The Role of the Liver in the Control of Vitamin D Metabolism
553 -
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Prostaglandins and 25-Hydroxyvitamin D-1a-Hydroxylase
563 -
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Regulation of Plasma Levels of 1,25 Dihydroxy Vitamin D in Growing Dogs with Thyroparathroidectomy and Varying Amounts of Parathyroid Hormone
567 -
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Both 24R,25-Dihydroxyvitamin D3 and 1a,25-Dihydroxyvitamin D3 are Indispensable for Normal Calcium and Phosphorus Homeostasis
571 -
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New Renal Metabolites of 24,25-Dihydroxyvitamin Ds in the Chick
579 -
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The 1a- and 24-Hydroxylases of 25-Hydroxycholecalciferol: one or two Enzymes?
587 -
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Regulation of 25-Hydroxycholecalciferol-1 and -24-Hydroxylases in Cultured Kidney Cells
597 -
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Possible Extra-Renal 25-OHD3-1a-Hydroxylase Activity in the Pregnant Rat
605 -
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The Absorption and Metabolism of Vitamin D3 from Parenteral Injection Sites
609 -
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1,25-(OH)2 Vitamin D3 & 24,25-(OH)2 Vitamin D3 Synthesis by the Isolated Perfused Rat Kidney
613 -
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In Vitro Regulation of 25-Hydroxyvitamin D3 Metabolism by Avian Kidney Cells in Serum-Free Medium
617 -
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Comparative Studies on Mitochondrial and Microsomal NADPH-Cytochromec Reductases of Chick Tissues
621 -
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Effect of Pregnancy, Acromegaly, Primary Hyperparathyroidism and Prolactinoma on 1,25-Dihydroxyvitamin D in Man
625 -
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Relationship of Dietary Phosphorus Restriction to Calcium Absorption and Vitamin D Metabolism
629 - Intestinal Actions and Calcium Binding Protein: Meaning of Non-Parallel 1,25-Dihydroxycholecalciferol Mediated
-
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Response Relationship in Intestine and Bone to Dose and Time
639 -
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Cytoplasmic Localization of the Calcium Binding Protein in Rat Duodenal Absorptive Cells
643 -
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Visualization of Vitamin D-Dependent Calcium Binding Protein in Chick Intestine by Immuno-Scanning Electron Microscopy
647 -
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Influence of High Doses of Vitamin D3 on Broilers and Adult Hens
651 -
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Purification of the Intestinal Receptor for 1,25-Dihydroxyvitamin D
659 -
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Recent Progress on the Application of Affinity and Covalent Chromatography to the Purification of the 1,25-Dihydroxyvitamin D3 Receptor from Chick Intestinal Mucosa
663 -
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1,25-Dihydroxycholecalciferol and the Prevention of Parturient Hypocalcemia and Paresis ("Milk Fever") in Pregnant Dairy Cows
667 -
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A Vitamin D-Induced, Calcium-Binding Protein from Rat Intestinal Brush Border
675 -
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Relationship of Intestinal Calcium Absorption to Intestinal and Plasma Calcium Binding Protein Measured by a Radioimmunoassay
679 -
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The Effect of 1,25-Dihydroxycholecalciferol and Hydrocortisone on the Development of the Embryonic Chick Duodenum
683 -
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Theories on the Mechanism of Action of 1,25(OH)3D3 on Active Intestinal Calcium and Inorganic Phosphate Absorption: are the Calcium and Phosphate Transport Processes Coupled, Uncoupled or Both?
687 -
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Fundamental Actions of 1,25 Dihydroxycholecalciferol on Intestinal Ion Transport do not Involve Gene Activation
693 -
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The Effect of Cholecalciferol on the Phosphorylation of Intestinal Membrane Proteins
703 -
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Some Biochemical Responses of Chick Intestine to 1,25- Dihydroxyvitamin D
711 -
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Induction of Metallothionein(s) in Organ-Cultured Duodenum: Relationship to 1a,25-(OH)2D3-lnduced CaBP Synthesis
731 -
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Vitamin D and Calcium Absorption: Computer Simulation
735 - Renal Osteodystrophy
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Clinical Assessments of Vitamin D3 - Therapy in Patients on Longterm Haemodialysis
745 -
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Adverse Effects of Vitamin D Metabolites on Osteitis Fibrosa in Patients on Chronic Hemodialysis: Critical Role of Induced Hyperphosphatemia
751 -
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Assessment of Long-Term Effects of 1a(OH)D3 on PTH Secretion, Intestinal Calcium Absorption and Bone in Chronic Renal Failure
755 -
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Hypergonadotropic Hypogonadism in Renal Failure - A Defect Responsive to 1,25(OH)2D3
763 -
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Comparative Effects of 1,25-Dihydroxycholecalciferol and Cholecalciferol in non-Dialyzed Chronic Renal Failure
767 -
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Medium term Effects of 1,25-Dihydroxy-vitamin D in Patients with Renal Osteopathy
771 -
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The Early Detection and Treatment of Renal Osteodystrophy
775 -
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The Combined Use of Human Calcitonin and 1,25-Dihydroxycholecalciferol in the Treatment of Renal Osteodystrophy
781 -
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Intestinal Calcium Transport in Vitro as Influenced by Azotemia, Dietary Calcium, Parathyroidectomy and 1,25-Dihydroxycholecalciferol (1,25-DHCC) Treatment. - Role of Calcium - ATPase
787 -
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Recurrence of Hyperparathyroidism from Autografted Parathyroid Fragments in Uremic Patients in Spite of Administration of 25(OH)D3 and 1a(OH)D3
791 -
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25 Hydroxycholecalciferol Plasma Levels in Anephric Patients After Oral Loading of Vitamin D
795 -
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The Histological Study on Experimental Renal Osteodystrophy in Rats
799 -
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Long Term Effects of Small Doses of 1,25 Dihydroxycholecalciferol in Dialysis Patients
803 -
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Clinical and Biological Efficiency of 1,25 Dihydrocholecalciferol in Chronic Dialysis Patients with Renal Osteodystrophy
807 -
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Histomorphometric Evaluation of the effect of 1,25-DHCC in Type II and III of Renal Bone Disorders
811 -
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Histomorphometry of Bone Changes in Renal Osteodystrophy After Treatment with 1,25-Dihydroxycholecalciferol
817 -
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The use of 5,6-trans-25-OH-Cholecalciferol in the Treatment of Patients with Fully Developed Renal Osteopathy Requiring Dialysis: Therapeutical Application and Treatment Results
821 -
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Clinical Experience in Long Term Treatment with 1,25-DHCC in Different Histological Forms of Renal Osteopathy
827 -
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Calcium-Phosphorus Metabolism and Renal Function During 1a-OH-D3 Vitamin Treatment of Patients with Chronic Renal Disease
831 -
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Newcastle Bone Disease
835 -
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The Measurement of 1,25-(OH)2-D by Competitive Protein Binding Assay in the Plasma of Anephric Patients: The Effects of Dihydrotachysterol Therapy
839 -
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25-Hydroxycholecalciferol and 1,25 Dihydroxycholecalciferol in the Treatment of Renal Osteodystrophy
843 -
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Bone Histomorphometry in Children with Early Chronic Renal Failure Treated with 25 (OH)D3
847 -
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Hypercalcemia During Treatment of Uremic Patients with 1,25(OH)2D3: Analysis of 43 Cases
851 -
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Renal Bone Disorder in Children: Therapy with Vitamin D3 or 1,25- Dihydroxycholecalciferol
853 -
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Treatment of Predialysis Renal Bone Disease with 1a-(OH) Vitamin D3 and 1.25-(OH)2 Vitamin D3. Initial Results of Balance Studies and the Effect on Intestinal Calcium Absorption, Serum PTH and Calcitonin Levels
861 -
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The Effect of 1-a-OHD3 on Bone Changes in Non-Dialysed Patients with Chronic Renal Insufficiency
865 -
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25 Hydroxyvitamin D in Renal Osteodystrophy: Long Term Results of A Six-Center Trial
869 -
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Further Therapeutical Experience with the Vitamin D Analog 5,6-trans-25-OHCC in Renal Osteopathy
877 -
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A New Laboratory Model for Renal Osteodystrophy and Vitamin D
885 -
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The Influence of Uremia, Aluminiumhydroxide and Various Vitamin D Compounds on the Course of Nutritional Rickets in Rats
893 -
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Effect of Vitamin D Analogs in Rats with Experimental Renal Osteodystrophy
901 -
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Evaluation of Histological Procedures in the Investigation of Bone Disease Related to Vitamin D
907 - Pathophysiology of Vitamin D Related Diseases
-
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Effects of in Vitro and in Vivo Sodium Restriction on Corticosteroidinduced Intestinal Calcium Malabsorption
915 -
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Trisetum Calcinosis: Current Status of Clinical Research
921 -
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X-Linked Hypophosphatemia is a Disorder of Phosphate Transport in the Renal Brush Border Membrane in the Hypophosphatemic Mouse. Why is Serum 1,25-(OH)2D Low in the Human Homologue?
925 -
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The Effect of Vitamin D3 and Metabolites on Magnesium Metabolism
933 -
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Subnormal Serum 1,25-Dihydroxyvitamin D3 Levels in Children with Glomerular Disease Receiving Corticosteroids
935 -
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Regulation of Serum Phosphorus by 1,25(OH)2D3
939 -
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Unexplained hypercalcemia:? Sarcoidosis sine Sarcoidosis: with Elevated Serum Level of 1,25 DHCC
941 -
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Vitamin D Metabolites in Hypercalcitoninemic States
945 -
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Target Cell Resistance in Pseudohypoparathyroidism: Single or Multiple?
949 -
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Vitamin D Metabolism In Patients with Nephrolithiasis
957 -
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Evidence for Abnormal Metabolism of Vitamin D in Sarcoidosis
963 -
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Effects of Experimental Diabetes in the Rat on Calcium Transport and Vitamin D Metabolism
967 -
Requires Authentication UnlicensedLicensed
Absorption of Vitamin D and 25-OH Vitamin D in patients with Intestinal Malabsorption
975 -
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Effect of Diabetes in Rats on the Metabolism of Cholecalciferol and 25-Hydroxycholecalciferol
979 -
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Do Alkaline Phosphatases Have a Physiological Function?
983 -
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Clinical Application of the 1,25-(OH)2D Assay
991 -
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Elevated Plasma 1,25-(OH)2D Following Massive Dosing of Vitamin D3 in Dairy Cattle
999 -
Requires Authentication UnlicensedLicensed
Vitamin D Metabolism in the Diabetic Rat
1003 -
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The Effect of Chronic Excess or Deficiency of Growth Hormone on Plasma 1,25-Dihydroxyvitamin D Levels in man
1005 -
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25-Hydroxylation of Vitamin D in the Elderly
1011 -
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Intestinal Absorption of Radiophosphate After Physiological Doses of 1,25-Dihydroxyvitamin D in Normals and Pathological Conditions
1015 -
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Calcium Metabolism Following Proximal Gastric Vagotomy in Man
1019 -
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25-Hydroxyvitamin D Metabolism in Nontropical Sprue
1023 -
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Circulating Vitamin D Metabolites in A Hypoparathyroid Patient Resistent to Vitamin D
1027 -
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The Ability of 1a, 25-Dihydroxycholecalciferol to Alter the Fatty Acid Composition of Phosphoglycerides in Rat Intestinal Mucosa and Smooth Muscle
1031 -
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Vitamin D Dependent Clinical Disorders - Bone Disease : Clinical Aspects - Unanswered Questions in Renal Osteodystrophy - Problems of Vitamin D Nomenclature - Addendum
1035 -
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Author Index
1261 -
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Subject Index
1273 -
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Backmatter
1319
Publishing information
Pages and Images/Illustrations in book
eBook published on:
October 26, 2020
eBook ISBN:
9783112330029
Hardcover published on:
December 31, 1979
Hardcover ISBN:
9783112330012
Edition:
Reprint 2020
Pages and Images/Illustrations in book
Front matter:
26
Main content:
1318
Other:
Num. figs.
Audience(s) for this book
College/higher education;
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