CONTENTS

Chapters in this book

1. Frontmatter I
2. PREFACE V
3. CONTENTS VII
4. SECTION I. THE INFLAMMATORY RESPONSE AND ACUTE PHASE REACTANT PROTEINS
5. INDUCTION AND CONTROL OF ACUTE PHASE REACTANT SYNTHESIS 3
6. USE OF IMMUNOMORPHOLOGICAL METHODS AND HEMOLYTIC PLAQUE TESTS TO INVESTIGATE THE SYNTHESIS AND SECRETION OF PLASMA PROTEINS BY THE LIVER CELLS DURING THE ACUTE INFLAMMATORY REACTION 15
7. PROGRESS IN PLASMA PROTEINS: RECENT FINDINGS ON THE STRUCTURE OF CERULOPLASMIN 25
8. RECENT FINDINGS ON THE ISOELECTRIC POINTS OF HUMAN C-REACTIVE PROTEIN 43
9. SAA IS A MORE SENSITIVE MARKER FOR CHRONIC INFLAMMATORY DISEASE THAN C-REACTIVE PROTEIN OR cti-ACID GLYCOPROTEIN 47
10. ELASTASE-c^PROTEINASE INHIBITOR COMPLEX (E-C^PI) AND C-REACTIVE PROTEIN (CRP): EARLY INDICATORS OF INFLAMMATORY PROCESSES 51
11. THE SYSTEM OF KALLIKREIN-KININOGENS-KININS (KKK) AND THE ACUTE-PHASE REACTANT PROTEINS (APRP) IN HUMANS UNDERGOING EXTRACORPOREAL CIRCULATION (ECC) 57
12. EFFECT OF NON STEROIDAL ANTI-INFLAMMATORY DRUG (NIFLUMIQUE ACIDE) ON ACUTE PHASE PROTEIN RESPONSE 71
13. TRANSCORTIN ACTIVITIES, CORTISOL AND PROGESTERONE IN PATHOLOGICAL SERA : INFLAMMATION, SEPTIC SHOCK, RENAL AND CARDIAC DISEASES 75
14. MEASURFMENT OFHUMAN HIGH MOLECULAR WEIGHT K I M N O G E N (HMW-K) BY L A S E R NEPHELOMETRY 79
15. SECTION II. BIOLOGICAL ROLES OF ACUTE PHASE REACTANT PROTEINS
16. FUNCTIONS OF ACUTE PHASE PROTEINS IN THE INFLAMMATORY RESPONSE 89
17. INTERACTION OF THE ACUTE PHASE REACTANTS O^-ACID GLYCOPROTEIN, C-REACTIVE PROTEIN AND SERUM AMYLOID P-COMPONENT WITH PLATELETS AND THE COAGULATION SYSTEM 99
18. MONOCLONAL ANTIBODIES AS PROBES OF COMPLEMENT FUNCTION 125
19. MODULATION OF FORMATION OF THE C3 AMPLIFICATION CONVERTASE OF HUMAN COMPLEMENT BY ACUTE PHASE PROTEINS 135
20. MATERNO-TROPHOBLASTIC RELATIONSHIP IN NORMAL HUMAN PREGNANCY AND RECURRENT SPONTANEOUS ABORTION 139
21. CHEMOTACTIC FACTORS IN THE AIRSPACES THAT MAY MODULATE INFLAMMATION 153
22. SECTION III. PROTEASE ANTI-PROTEASE INTERACTIONS AND LUNG DISEASES 169
23. HUMAN a₁-ANTICHYMOTRYPSIN : PURIFICATION, PROPERTIES AND REACTIONS WITH SOME SERINE PROTEASES 171
24. ALPHA₁-MTITRYPSIN-PROTEASE INTERACTIONS: THE BIOLOGICAL ASPECT 181
25. ON THE INTERACTION BETWEEN HUMAN LIVER CATHEPSIN L AND THE TWO CYSTEINE PROTEINASES INHIBITORS PRESENT IN HUMAN SERUM 203
26. MODULATION OF HUMAN LYMPHOCYTE RESPONSES BY a i ANTITRYPSIN AND a2 MACROGLOBULIN 207
27. MEDIATORS OF INFLAMMATION IN INFLAMMATORY ALVEOLITIS 219
28. IDIOPATHIC PULMONARY FIBROSIS. MULTIPARAMETRIC EVALUATION OF ALVEOLAR LYMPHOCYTE AND MACROPHAGE ACTIVATION 223
29. THE ALPHA₁ PROTEINASE INHIBITOR OF THE LOWER RESPIRATORY TRACT. EFFECT OF CIGARETTE SMOKING 227
30. COLLAGENOLYTIC ENZYMES AND FIBROSIS OF THE LUNG 231
31. ELASTOLYTIC ACTIVITIES AND PROTEINASE INHIBITORS IN SPUTUM FROM PATIENTS WITH CYSTIC FIBROSIS 235
32. SERUM DERIVED PROTEINS AND ANTIBACTERIAL PROTEINS IN CYSTIC FIBROSIS SPUTUM 239
33. ALVEOLAR FIBRONECTIN AND INTERSTITIAL LUNG DISEASES 243
34. SARCOIDOSIS : IgG, ß₂ MICROGLOBULIN AND EVOLUTIVITY 247
35. α₁-PROTEINASE INHIBITOR IN MECONIUM FROM HEALTHY INFANTS AND INFANTS WITH CYSTIC FIBROSIS 251
36. QUALITATIVE ANALYSIS OF PROTEINS OF ALVEOLAR FLUID 255
37. PROTEASE-ANTIPROTEASE IMBALANCE IN LUNG DISEASE 261
38. SECTION IV. INFLAMMATION AND ARTICULAR DISEASES
39. THE ACUTE PHASE RESPONSE IN CONNECTIVE TISSUE DISEASE 273
40. THE GLA-CONTAINING PROTEIN OF BONE 281
41. ROLE OF AN ACUTE PHASE REACTANT, RETROVIRAL gp70, IN MURINE SLE 295
42. STUDY OF 8 MARKER PROTEINS OF INFLAMMATION IN SYNOVIAL FLUID AND SERUM OF PATIENTS WITH JOINT DISEASES 305
43. FIBRONECTIN IN ARTHROPATHIES 311
44. SECTION V. INFLAMMATORY DISEASES OF NERVOUS SYSTEM
45. MULTIPLE SCLEROSIS: CLUES FOR ITS PATHOGENESIS 319
46. IMMUNOGLOBULINS IN NEUROPATHOLOGY 339
47. CELLULAR INFLAMMATORY RESPONSE IN CEREBROSPINAL FLUID 345
48. EVALUATION OF CSF LYMPHOCYTE SUBSETS USING THE OKT SERIES OF MONOCLONAL ANTIBODIES (OKT₃ + , OKT₄+ , 0KT₈ + ) IN VARIOUS NEUROLOGICAL DISEASES 355
49. CYTOLOGICAL STUDY AND PROTEIN PROFILE IN CEREBROSPINAL FLUID, BEFORE AND DURING TREATMENT OF NEUROSYPHILIS 359
50. CEREBROSPINAL FLUID CYTOLOGY AND PROTEIN PARAMETERS IN 219 MULTIPLE SLCEROSIS 365
51. INTERPRETATION OF THE PROTEIN PROFILE OF CEREBROSPINAL FLUID IN CHILDREN 369
52. CEREBROSPINAL FLUID FERRITIN : INTEREST AS BIOLOGICAL MARKER OF CENTRAL NERVOUS SYSTEM TUMORS 375
53. CLINICAL RELEVANCE OF BETA 2 MICROGLOBULIN LEVELS OF THE CEREBROSPINAL FLUID IN CHILDREN WITH ACUTE ENCEPHALITIS 379
54. ELECTROPHORETICAL PATTERNS OF ACETYLCHOLINESTERASE IN CEREBROSPINAL FLUID 383
55. CHOLINESTERASE ISOENZYMES OF CEREBROSPINAL FLUID AND GUILLAIN-BARRE SYNDROME 387
56. LYMPHOCYTOTOXIC AND MONOCYTOTOXIC ANTIBODIES IN MULTIPLE SCLEROSIS 391
57. INTEREST OF A HIGH RESOLUTION AGAROSE GEL ELECTROPHORESIS SYSTEM (PANAGEL^R) WITH A SILVER STAINING REVELATION IN THE STUDY OF CEREBROSPINAL FLUID (C. S. F.) IMMUNOGLOBULIN G 395
58. TWO DIMENSIONAL ELECTROPHORESIS OF CSF PROTEINS : ELECTROPHORESIS QUALITY CONTROL 401
59. SECTION VI. INFLAMMATION AND MALNUTRITION
60. ANTHROPOMETRIC AND BIOLOGICAL CHARACTERIZATION OF MALNUTRITION STATES IN MAN 409
61. NEW FINDINGS ON THE ROLE OF ZINC AS A BIOLOGICAL RESPONSE MODIFIER 421
62. IMMUNODEFICIENCY IN PROTEIN OR VITAMIN A DEPRIVED MICE 429
63. IMMUNOLOGICAL CONSEQUENCES OF PROTEIN DEPRIVATION IN PRIMATES 439
64. SERUM THYMIC FACTOR (FTS) CONTENTS OF THE THYMUS IN UNDERNOURISHED SENEGALESE CHILDREN 453
65. THE CLINICO-PATHOLOGICAL CONSEQUENCES OF SEVERE PROTEIN-ENERGY MALNUTRITION IN DECEASED SENEGALESE CHILDREN 457
66. PROTEIN PROFILE AND THYMIC FUNCTION IN PROTEIN-ENERGY MALNUTRITION WITHOUT SURIMPOSED INFECTIONS : ANOREXIA NERVOSA 461
67. MALNUTRITION IN CANCER AND CACHECTIC PATIENTS 465
68. MARKER PROTEINS OF INFLAMMATION AND NUTRITION IN ADVANCED CANCER 477
69. NUTRITIONAL AND INFLAMMATORY STATUS IN 26 CASES OF MALIGNANT HEMOP ATHIES OF THE INFANCY 481
70. COMPARISON BETWEEN CRP SERUM VALUES AND HEMATOLOGICAL PARAMETERS FOR DIAGNOSIS AND THERAPEUTIC SURVEILLANCE OF NEONATAL INFECTION 485
71. CONTRIBUTION OF PRINCIPAL COMPONENTS ANALYSIS TO THE STUDY OF INFLAMMATORY AND NUTRITIONAL STATUS ON INTENSIVE CARE PATIENTS 489
72. EFFECTS OF NUTRITION ON THE POST-OPERATIVE SERUM LEVELS OF PREALBUMIN (PA), TRANSFERRIN (T) AND FIBRONECTIN (FN). 493
73. SURGERY INDUCED MODIFICATIONS OF PLASMA PROTEINS LEVELS 497
74. STUDY OF 8 PLASMA PROTEINS DURING A CASE OF SEVERE HEAT STROKE 503
75. SERUM PROTEIN PROFILE EVOLUTION AFTER SUB-TOTAL HEPATECTOMY 507
76. MALNUTRITION AND IMMUNITY IN CHRONIC HEAVY DRINKERS WITH AND WITHOUT CIRRHOSIS 513
77. BIOLOGICAL NUTRITIONAL MARKERS WHICH POORLY REFLECT THE ACTIVITY OF CROHN'S DISEASE 519
78. PREDICTION OF SUCCESS OR FAILURE OF PARENTERAL ALIMENTATION IN THE TREATMENT OF SEVERE FORMS OF CROHN'S DISEASE AND RECTOCOLITIS 523
79. ALBUMIN ASSAY WITH ASTRA 8 BY A TECHNIC USING BROMOCRESOL GREEN : QUALITY CRITERIA, COMPARISON WITH NEPHELEMETRY 527
80. QUANTITATIVE ESTIMATE OF THE NUTRITIONAL STATUS THROUGH THE MEASUREMENT OF THE ELECTRICAL BODY IMPEDENCE 531
81. SECTION VII. MARKER PROTEINS IN EXPERIMENTAL MODELS OF INFLAMMATION
82. CHARACTERIZATION OF CIRCULATING 04-ACID GLYCOPROTEIN IN NORMAL AND INFLAMMATORY MICE 539
83. THE INFLAMMATORY REACTION OF THE DEVELOPING RAT : RESPONSES OF SERUM STEROID HORMONES AND PROTEINS 549
84. THE EFFECTS OF ETHINYL_OESTRADIOL AND OF ACUTE INFLAMMATION ON THE PLASMA LEVEL OF RAT ALPHA-1"ACID GLYCOPROTEIN AND ON THE CELL'FREE TRANSLATION OF ITS HEPATIC mRNA 553
85. EVIDENCE FOR THE IDENTITY BETWEEN α1-CYSTEINE-PROTEINASE-INHIBITOR AND α1-ACUTE-PHASE GLOBULIN IN RAT SERUM 557
86. CHANGES IN CONCENTRATION OF FIVE RAT SERUM PROTEINASE-INHIBITORS DURING EXPERIMENTAL DIABETES. POSSIBLE RELEVANCE TO NON ENZYMATIC GLYCOSYLATION 561
87. ACUTE PHASE REACTANTS, THROMBOXANE AND PROSTACYCLIN DURING CALCIUM PYROPHOSPHATE-INDUCED PLEURISY IN THE RAT 565
88. STUDY OF THE GLYCOSYLATED VARIANTS OF CHICKEN HAPTOGLOBIN 569
89. EVIDENCE FOR THE PRESENCE IN CHICKEN PLASMA OF A LIGAND FOR HAPTOGLOBIN WHICH DIFFERS FROM HEMOGLOBIN 575
90. EFFECT OF AN ACUTE INFLAMMATORY REACTION ON THE HAPTOGLOBIN, ALBUMIN, CYTOCHROME P-450 CONTENTS AND GLUCOSE-6-PHOSPHATASE ACTIVITY IN HEPATIC MICROSOMAL FRACTIONS IN THE RAT 581
91. CIRCADIAN VARIATION IN PMN—MIGRATION INDUCED BY LIVE BCG IN SWISS MICE 585
92. SECTION VIII. LECTINS
93. INTRODUCTIVE NOTES 591
94. PART 1. LECTINS AS TOOLS
95. THE USE OF LECTINS TO STUDY CHANGES IN RAT PLATELET MEMBRANE GLYCOPROTEINS INDUCED BY ORAL CONTRACEPTIVES 597
96. IDENTIFICATION OF CYTOPLASMIC AND MEMBRANE PLATELET GLYCOPROTEINS USING A COMBINATION OF SDS - POLYACRYLAMIDE GEL ELECTROPHORESIS AND 125I-LABELLED LECTINS 601
97. CHARACTERIZATION OF HUMAN EPIDERMAL GLYCOPROTEINS RECOGNIZED BY THE LECTINS CON A AND PNA 605
98. FLUORESCENT LECTINS AND QUANTITATIVE MICROSCOPY 609
99. EFFECTS OF SERUM ON LECTIN-INDUCED LYMPHOCYTE PROLIFERATION 613
100. CONCANAVAI.IN A AND PROTHROMBIN COMPLEX 615
101. MODIFICATION OF THYMIDINE TRANSPORT IN LECTIN-STIMULATED LYMPHOCYTES 619
102. INDUCTION OF A THYMIDINE METABOLISME ENZYME IN HUMAN LYMPHOCYTES STIMULATED BY THE ROBINIA PSEUDOACACIA LECTIN 621
103. LECTINS OF ROBINIA PSEUDOACACIA 625
104. SPECIFICITY OF HUMAN PLASMA FIBRONECTIN TOWARDS BIOMATERIALS 627
105. STUDY OF THE GLYCOSYLATED POPULATIONS OF PLASMA ALPHA-1"ACID GLYCOPROTEIN IN HUMAN BREAST CANCER PATIENTS TREATED WITH TAMOXIFEN 631
106. PHYSICO-CHEMICAL AND BIOCHEMICAL CHARACTERISTICS OF THE CON-A REACTIVE AND NON REACTIVE MOLECULAR VARIANTS OF HUMAN ALPHA-1"ACID GLYCOPROTEIN 635
107. PART 2. BIOLOGICAL FUNCTIONS OF LECTINS
108. BIOLOGICAL FONCTIONS OF LECTINS 641
109. LOCALIZATION AND BIOSYNTHESIS OF LATHYRUS OCHRUS SEEDS LECTIN 651
110. SURFACE AND TOTAL RECEPTORS FOR ASIALOGLYCOPROTEINS IN HEPATOCYTES FROM DIABETIC RATS 655
111. PART 3. AFFINITY AND SPECIFICITY OF LECTINS
112. LECTIN(S) - LIGAND(S) INTERACTIONS 661
113. A COMPARATIVE STUDY OF AFFINITY CONSTANTS MEASURED BY DIFFERENT METHODS, BETWEEN PEANUT LECTIN AND SUGARS WITH GALACTOSYL MODIFIED ON C(6) OR C(l) 665
114. EFFECT OF pH ON BINDING PROPERTIES OF PEANUT AGGLUTININ (PNA) 671
115. USE OF LECTIN S TO EXAMINE THE MICROHETEROGENEITY OF RAT HEMOPEXIN 673
116. AUTHOR INDEX 679
117. SUBJECT INDEX 683
118. Backmatter 688