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Machine learning approaches for optimizing the synthesis and functionalization of quantum dots for medical imaging

  • K. Dhanasekaran , Monelli Ayyavaraiah ORCID logo , M. Anand , Mohit Tiwari , J. Vinisha and S. Praveena
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Abstract

Recent advances in biomedical engineeringbiomedical engineering show that quantum dots (QDs) are powerful imaging agents that exhibit desirable characteristics like size-tunable emission and photostability. In this chapter we review the synthesis of QDs and their surface functionalization, with an emphasis on their employment in state-of-the-art imaging systems. Of course, there are discussion of the effects of QD size and the surface structure on optical characteristics, advantages and disadvantages of various synthesis methodologies, and the difficulties that QD production poses for cost reduction and manufacturability. In addition to providing an overview of the synthesis of QDs andQDs, functionalization of QDs for biomedical applications, the chapter also discusses recent developments in the area of surface coatings in QD that improve their biocompatibility and specificity in medical applications. This chapter seeks to map the existing and future agenda for QD technology by analyzing the possible developments and limitations as of today and suggest future research questions that enable the practical implementation of this technology. Major topics covered include synthesis of QDs and their surface chemistry, optical characteristics, and functionalization of the particles; and the issues of cost and practical bottlenecks to the commercial exploitation of the materialmaterial.

Abstract

Recent advances in biomedical engineeringbiomedical engineering show that quantum dots (QDs) are powerful imaging agents that exhibit desirable characteristics like size-tunable emission and photostability. In this chapter we review the synthesis of QDs and their surface functionalization, with an emphasis on their employment in state-of-the-art imaging systems. Of course, there are discussion of the effects of QD size and the surface structure on optical characteristics, advantages and disadvantages of various synthesis methodologies, and the difficulties that QD production poses for cost reduction and manufacturability. In addition to providing an overview of the synthesis of QDs andQDs, functionalization of QDs for biomedical applications, the chapter also discusses recent developments in the area of surface coatings in QD that improve their biocompatibility and specificity in medical applications. This chapter seeks to map the existing and future agenda for QD technology by analyzing the possible developments and limitations as of today and suggest future research questions that enable the practical implementation of this technology. Major topics covered include synthesis of QDs and their surface chemistry, optical characteristics, and functionalization of the particles; and the issues of cost and practical bottlenecks to the commercial exploitation of the materialmaterial.

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