Vitamin B12: Proceedings of the 3rd European Symposium on Vitamin B12 and Intrinsic Factor, University of Zurich, March 5–8, 1979, Zurich, Switzerland

Book

Vitamin B12

Proceedings of the 3rd European Symposium on Vitamin B12 and Intrinsic Factor, University of Zurich, March 5–8, 1979, Zurich, Switzerland

Edited by: B. Zagalak , W. Friedrich , 1979, Zürich> European Symposium on Vitamin B 12 and Intrinsic Factor <3 and Universität <Zürich>

Language: English

Published/Copyright: 1979

Published by

Become an author with De Gruyter Brill

Explore this Subject How to publish with us

Topics

Publicly Available

Frontmatter
I

Download PDF
Publicly Available

Preface
VII

Download PDF
Publicly Available

CONTENTS
IX

Download PDF
Chapter 1. CHEMISTRY OF CORRINOIDS. TOTAL SYNTHESIS OF VITAMIN B₁₂
Requires Authentication Unlicensed

Licensed

Introductory remarks for opening of 3rd European Symposium on vitamin B₁₂
1
Lord Todd, O. M. and P. R. S.

Download PDF
Requires Authentication Unlicensed

Licensed

Introductory remarks. Historical perspectives on the isolation of crystalline vitamin B₁₂
7
K. Folkers

Download PDF
Requires Authentication Unlicensed

Licensed

New and old problems in the structure analysis of vitamin B₁₂
19
Dorothy Crowfoot Hodgkin

Download PDF
Requires Authentication Unlicensed

Licensed

Synthetic vitamin B₁₂
37
R. B. Woodward

Download PDF
Requires Authentication Unlicensed

Licensed

Chemical synthesis of corrinoids: current problems and recent advances
89
A. Eschenmoser

Download PDF
Requires Authentication Unlicensed

Licensed

Recent studies on the synthesis of vitamin B₁₂
119
R. V. Stevens

Download PDF
Requires Authentication Unlicensed

Licensed

New reactions of the chromophoric system of vitamin B₁₂ derivatives
137
H. H. Inhoffen

Download PDF
Requires Authentication Unlicensed

Licensed

Structure and reactivity of the so-called stable yellow corrinoids
141
B. Grüning and A. Gossauer

Download PDF
Requires Authentication Unlicensed

Licensed

Concerning the structure of so-called yellow products obtained from naturally occurring metal-free corrinoids
149
G. Schlingmann and V. B. Koppenhagen

Download PDF
Requires Authentication Unlicensed

Licensed

Correlation of vitamin B₁₂ methanolysis products with cobyrinic methyl ester amides prepared from hydrogenobyrinic acid amides
155
G. Schlingmann, B. Dresow, L. Ernst and V. B. Koppenhagen

Download PDF
Requires Authentication Unlicensed

Licensed

Preparation and X-ray structural analyses of a cobyrinic acid diamide and the corresponding rhodium analogue
159
B. Dresow, V. B. Koppenhagen and W. S. Sheldrick

Download PDF
Requires Authentication Unlicensed

Licensed

Concerning a new corrinoid from municipal sludge
163
W. Friedrich

Download PDF
Requires Authentication Unlicensed

Licensed

Steric course of the substitution by vitamin B_12s as studied by ¹H-NMR spectroscopy
169
M. Fountoulakis and J. Rétey

Download PDF
Requires Authentication Unlicensed

Licensed

Synthesis and X-ray analysis of a porphyrin-type Co(I)-complex
171
P. Engel, G. Rytz, L. Walder, U. Vögeli and R. Scheffold

Download PDF
Requires Authentication Unlicensed

Licensed

Stereochemistry of the formation and cleavage of the Co-C bond in a vitamin B₁₂ model
173
G. Rytz, L. Walder and R. Scheffold

Download PDF
Requires Authentication Unlicensed

Licensed

The structure of superoxocobalamin, a single crystal ESR study
175
E. Jörin, A. Schweiger and Hs. H. Günthard

Download PDF
Requires Authentication Unlicensed

Licensed

NMR studies of a novel form of vitamin B₁₂
179
R. K. Gupta, P. C. Goswami and A. Nath

Download PDF
Requires Authentication Unlicensed

Licensed

Circular dichroism study of organocobalamins
183
I. P. Rudakova, T. A. Pospelova, E. M. Tachkova and A. M. Yurkevich

Download PDF
Requires Authentication Unlicensed

Licensed

Concerning electronic, CD and ORD spectra of isomeric pairs of several (Co-methyl)-corrinoids
189
M. Moskophidis

Download PDF
Requires Authentication Unlicensed

Licensed

Some properties of cobalaminhexacyanoferrate
193
Y. Popova and S. Angelova

Download PDF
Requires Authentication Unlicensed

Licensed

Temperature-jump kinetics of the "base-on" - "base-off" equilibrium of methylcobalamin
199
K. L. Brown, A. W. Awtrey, P. B. Chock and S. G. Rhee

Download PDF
Requires Authentication Unlicensed

Licensed

Electrochemistry of vitamin B₁₂. Equilibria, kinetics and mechanisms in the B_12a - B_12r - B_12s oxido-reduction
203
J. M. Savéant, N. de Tacconi, D. Lexa and J. Zickler

Download PDF
Requires Authentication Unlicensed

Licensed

Electrochemistry of vitamin B₁₂. Alkyl cobalamins and cobinamides
213
D. Lexa, J. M. Savéant and J. P. Soufflet

Download PDF
Chapter 2. BIOSYNTHESIS OF CORRINOIDS
Requires Authentication Unlicensed

Licensed

Recent biosynthetic researches on vitamin B₁₂
217
A. R. Battersby

Download PDF
Requires Authentication Unlicensed

Licensed

Intermediary metabolism of cobyrinic acid biosynthesis
247
A. I. Scott

Download PDF
Requires Authentication Unlicensed

Licensed

On the methylation process in cobyrinic acid biosynthesis
279
G. Müller, R. Deeg, K. D. Gneuß, G. Gunzer and H. -P. Kriemler

Download PDF
Requires Authentication Unlicensed

Licensed

Biogenesis of tetrapyrrole compounds (porphyrins and corrinoids), and its regulation
293
V. Ya. Bykhovsky

Download PDF
Requires Authentication Unlicensed

Licensed

Factor I ex Clostridium tetanomorphum: proof of structure and relationship to vitamin B₁₂ biosynthesis
315
M. Imfeld, D. Arigoni, R. Deeg and G. Müller

Download PDF
Requires Authentication Unlicensed

Licensed

On the biosynthesis of the 5,6-dimethylbenzimidazole moiety of vitamin B₁₂
317
P. Renz, J. Hörig and R. Wurm

Download PDF
Requires Authentication Unlicensed

Licensed

The enzyme system of propionic acid bacteria transforming riboflavin into 5,6-dimethylbenzimidazole
323
J. Hörig and P. Renz

Download PDF
Requires Authentication Unlicensed

Licensed

Straight approaches to the nucleotide loop
331
H. C. Friedmann

Download PDF
Requires Authentication Unlicensed

Licensed

Ribosomal proteins share in vitamin B₁₂ biosynthesis
345
W. Walerych and E. Pezacka

Download PDF
Requires Authentication Unlicensed

Licensed

The ribosomal proteins L2, L5, L18 and L25 involved in vitamin B₁₂ biosynthesis
359
E. Pezacka and W. Walerych

Download PDF
Requires Authentication Unlicensed

Licensed

Formation and role of vitamin B₁₂ in Protaminobacter ruber and Rhizobium meliloti
361
K. Sato, S. Inukai, S. Ueda, T. Seki and S. Shimizu

Download PDF
Chapter 3. CORRINOID DEPENDENT ENZYMES AND REACTIONS. MODEL SYSTEMS
Requires Authentication Unlicensed

Licensed

Current status of the mechanism of action of B₁₂ - coenzyme
373
R. H. Abeles

Download PDF
Requires Authentication Unlicensed

Licensed

A stereochemical approach to the diol dehydratase reaction
389
D. Arigoni

Download PDF
Requires Authentication Unlicensed

Licensed

Coenzyme B₁₂-dependent diol dehydratase - distribution and metabolic role in Enterobacteriaceae, enzymological properties and interaction with coenzyme B₁₂
413
Saburo Fukui and Tetsuo Toraya

Download PDF
Requires Authentication Unlicensed

Licensed

Adenosylcobalamin-dependent glycerol dehydratase interaction with substrates and their analogs
431
A. A. Poznanskaya and T. L. Korsova

Download PDF
Requires Authentication Unlicensed

Licensed

Glycerol dehydratase from Aerobacter aerogenes
437
B. Zagalak

Download PDF
Requires Authentication Unlicensed

Licensed

The mechanism of action of methylmalonyl-CoA mutase as studied with isotope labelling and synthetic models
439
J. Rétey

Download PDF
Requires Authentication Unlicensed

Licensed

Recent studies on the mechanism of action of ethanolamine ammonia-lyase
461
Bernard M. Babior

Download PDF
Requires Authentication Unlicensed

Licensed

Studies on the mechanism of reactions catalysed by ethanolamine ammonia-lyase
471
M. R. Hollaway, H. A. White, K. N. Joblin, A. W. Johnson, M. F. Lappert and O. C. Wallis

Download PDF
Requires Authentication Unlicensed

Licensed

Steric course of the ethanolamine-ammonia lyase reaction
485
P. Diziol, H. Haas, J. Rétey, S. Graves and B. M. Babior

Download PDF
Requires Authentication Unlicensed

Licensed

The chemical synthesis and coenzymatic properties of analogs of adenosylcobalamin in the ribonucleotide reductase reaction
489
H. P. C. Hogenkamp

Download PDF
Requires Authentication Unlicensed

Licensed

Review of the EPR of B_12r and B₁₂ -dependent enzyme reactions
505
John R. Pilbrow

Download PDF
Requires Authentication Unlicensed

Licensed

Vitamin B₁₂: current problems and recent advances
511
G. N. Schrauzer, J. H. Grate, M. Hashimoto and A. Maihub

Download PDF
Requires Authentication Unlicensed

Licensed

The role of corrinoids in the total synthesis of acetate from C0₂
529
Harland G. Wood

Download PDF
Requires Authentication Unlicensed

Licensed

Mechanisms for B₁₂ -dependent methylation
539
J. M. Wood and Y.-T. Fanchiang

Download PDF
Requires Authentication Unlicensed

Licensed

Nonenzymic models for the enigmatic coenzyme B₁₂-dependent carbon-skeleton rearrangements
557
Paul Dowd

Download PDF
Requires Authentication Unlicensed

Licensed

The mechanism of action of coenzyme B₁₂
575
D. Dolphin, A. R. Banks, W. R. Cullen, A. R. Cutler and R. B. Silverman

Download PDF
Requires Authentication Unlicensed

Licensed

Model systems for adenosylcobalamin dependent enzymic reactions
587
M. P. Atkins, B. T. Golding and P. J. Sellars

Download PDF
Requires Authentication Unlicensed

Licensed

Bridged cobaloximes as vitamin B₁₂ models
599
J. A. Robinson

Download PDF
Requires Authentication Unlicensed

Licensed

Modified adenosylaobalamin: model systems for the active sites of corrinoid-dependent enzymes
605
D. L. Anton and H. P. C. Hogenkamp

Download PDF
Chapter 4. ANALOGUES AND ANTAGONISTS OF VITAMIN B₁₂
Requires Authentication Unlicensed

Licensed

Naturally occurring vitamin B₁₂ antagonists and their potential therapeutic value
609
D. Perlman, K. L. Perlman, T. H. Williams, U. Schömer and Y. Izumi

Download PDF
Requires Authentication Unlicensed

Licensed

Structures of some vitamin B₁₂ analogues and their biological as well as biochemical functions
625
T. Kamikubo and M. Hayashi

Download PDF
Requires Authentication Unlicensed

Licensed

Novel metal-free corrinoids and metal analogues
635
V. B. Koppenhagen, E. Warmuth, G. Schlingmann and B. Dresow

Download PDF
Requires Authentication Unlicensed

Licensed

Preparation of ferribalamin, the Fe(III)-analogue of vitamin B₁₂
647
R. Bieganowski and W. Friedrich

Download PDF
Chapter 5. VITAMIN B₁₂ ASSAY
Requires Authentication Unlicensed

Licensed

Vitamin B₁₂ assay: an evaluation of radiodilution assay using cobinamide to increase specificity
649
B. A. Cooper, J. Peyman, Erika Jonas and V. M. Whitehead

Download PDF
Requires Authentication Unlicensed

Licensed

Effect of residual extract products and the type of binders (R or IF) on serum vitamin B₁₂ levels by radioisotope dilution assay
655
A. Begley and Charles A. Hall

Download PDF
Requires Authentication Unlicensed

Licensed

Differential assay of cobamides in serum using R-protein radioisotopic dilution assay, E.coli and E.gracilis assays
657
N. A. Sourial and D. L. Mollin

Download PDF
Requires Authentication Unlicensed

Licensed

Rapid determination of corrinoids by high performance liquid chromatography
663
D. Jacobsen, R. Green and M. Savage

Download PDF
Requires Authentication Unlicensed

Licensed

Determination of the plasma cobalamins by one-dimensional thin-layer chromatography
665
P. Gimsing, E. Hippe and Ebba Nexø

Download PDF
Requires Authentication Unlicensed

Licensed

Chemical quantitation of corrinoids
671
B. Zagalak

Download PDF
Requires Authentication Unlicensed

Licensed

Enzymatic estimation of vitamin B₁₂
673
Zenon Schneider

Download PDF
Requires Authentication Unlicensed

Licensed

Essential prerequisites for the analysis of cyanocobalamin in biochemically complex samples using radiometric competitive binding assays
675
R. A. Beck

Download PDF
Chapter 6. ABSORPTION, TRANSPORT AND DISTRIBUTION OF VITAMIN B₁₂
Requires Authentication Unlicensed

Licensed

Distribution of cobalamins in the animal body
681
D. M. Matthews

Download PDF
Requires Authentication Unlicensed

Licensed

Vitamin B₁₂ in membrane mimetic agents - theoretical considerations and practical applications
695
Janos H. Fendler

Download PDF
Requires Authentication Unlicensed

Licensed

Transport of vitamin B₁₂ in Escherichia coli
711
Clive Bradbeer

Download PDF
Requires Authentication Unlicensed

Licensed

The plasma transport of cobalamin (Cbl)
725
Charles A. Hall

Download PDF
Requires Authentication Unlicensed

Licensed

Soluble and membrane-bound vitamin B₁₂ transport proteins
743
R. Gräsbeck

Download PDF
Requires Authentication Unlicensed

Licensed

The origin and clinical implications of vitamin B₁₂ binders - the transcobalamins
765
B. Rachmilewitz, M. Schlesinger, R. Rabinowitz and M. Rachmilewitz

Download PDF
Requires Authentication Unlicensed

Licensed

Large vitamin B₁₂-binding proteins and complexes in human serum
777
Ralph Carmel

Download PDF
Requires Authentication Unlicensed

Licensed

Heterogeneity of antibodies against B₁₂ binders in pernicious anaemia
791
J. P. Nicolas

Download PDF
Requires Authentication Unlicensed

Licensed

The intraluminal phase of vitamin B₁₂ transport in humans
803
Y. Parmentier, G. Marcoullis, J. P. Nicolas and M. O. Perrin

Download PDF
Requires Authentication Unlicensed

Licensed

Polymorphic variants of transcobalamin II rare alleles in family studies
807
Marijke Fràter-Schröder, R. Osusky, W. H. Hitzig, R. Bütler and Aila Hasler-Häkkinen

Download PDF
Requires Authentication Unlicensed

Licensed

Relationship between cobalophilin releasing and functional state of polymorphonuclear granulocytes
813
W. Fenrych, J. Hansz, K. Boduch and B. Pytlak

Download PDF
Requires Authentication Unlicensed

Licensed

The significance of vitamin B₁₂ binders in the central nervous system
821
M. Inada, M. Kameyama and M. Toyoshima

Download PDF
Requires Authentication Unlicensed

Licensed

In vitro acid dissociation of cobalamin-transcobalamin II complexes formed in vivo: a probe in the study of TC II-kinetics
827
H. Gilbert

Download PDF
Requires Authentication Unlicensed

Licensed

Calcium dependencies in the binding of transcobalamins to subcellular particles of liver cells
833
Carter M. Becker and William S. Beck

Download PDF
Requires Authentication Unlicensed

Licensed

The effect of antibiotics on transcobalamin II synthesis in rabbit liver cell culture
837
C. H. Tan and T. J. Broekelmann

Download PDF
Requires Authentication Unlicensed

Licensed

Solubilization and characterization of the transcobalamin II acceptor from human placenta and rabbit liver
843
Ebba Nexø, M. D. Hollenberg and H. Olesen

Download PDF
Requires Authentication Unlicensed

Licensed

Strength of binding of methyl-, 5 '-deoxyadenosyl-, cyano- and hydroxocobalamin to human transcobalamin I and II and intrinsic factor
851
Ebba Nexø, H. Olesen and Marianne R. Hansen

Download PDF
Requires Authentication Unlicensed

Licensed

Adsorptive endocytosis of transcobalamin II-vitamin B₁₂ by isolated rat liver parenchymal cells
855
J. Lindemans, J. van Kapel and J. Abels

Download PDF
Requires Authentication Unlicensed

Licensed

Species specificity between TC II, TC II-Cbl uptake and anti-TC II
861
Mary Haus, Pamela D. Green and Charles A. Hall

Download PDF
Requires Authentication Unlicensed

Licensed

Transcobalamin II polymorphism in african populations
863
H. J. Porck, M. Frater-Schröder and A. K. Häkkinen

Download PDF
Requires Authentication Unlicensed

Licensed

Transcobalamins during induction of nutritional cobalamin deficiency in the fruit bat
867
R. Green, P. Myers and D. Jacobsen

Download PDF
Requires Authentication Unlicensed

Licensed

Heterogeneity of transcobalamin II demonstrated by isoelectric focusing in urea
873
U.-H. Stenman and E. -M. Salonen

Download PDF
Requires Authentication Unlicensed

Licensed

Radioimmunosorbent determinations of unsaturated and total transcobalamin II in human serum
877
Marijke Fràter-Schröder, P. Vitins and W. H. Hitzig

Download PDF
Requires Authentication Unlicensed

Licensed

The "dU suppression test" and "thymidine suppression test": evidence for reciprocal relationship between the "de novo" and "salvage" pathways of DNA synthesis
881
K. C. Das and V. Herbert

Download PDF
Requires Authentication Unlicensed

Licensed

TC II deficiency: observations with deoxyuridine suppression test
889
J. F. Burman, P. N. Malleson, N. A. Sourial and D. L. Mollin

Download PDF
Requires Authentication Unlicensed

Licensed

Spectral studies on hog intrinsic factor and hog non-intrinsic factor
895
Ebba Nexø, H. Olesen and Marianne R. Hansen

Download PDF
Requires Authentication Unlicensed

Licensed

Amino terminal sequence of hog non-intrinsic factor and hog intrinsic factor
905
D. Bucher, J. Thomsen, H. Olesen and Ebba Nexø

Download PDF
Requires Authentication Unlicensed

Licensed

Subunit structure of the pig ileal intrinsic factor receptor
909
Ilkka Kouvonen and Ralph Gräsbeck

Download PDF
Requires Authentication Unlicensed

Licensed

Cobinamide blocking assay for intrinsic factor
917
James A. Begley, Alan Trachtenberg and Charles A. Hall

Download PDF
Requires Authentication Unlicensed

Licensed

Intracelular transport of vitamin B₁₂ in enterocytes
919
M. Inada, M. Toyoshima and M. Kameyama

Download PDF
Requires Authentication Unlicensed

Licensed

Evidence for the chief cell as the source of intrinsic factor secretion in the rat
921
P. C. Sharpe and M. A. Horton

Download PDF
Requires Authentication Unlicensed

Licensed

Long-term treatment of pernicious anemia patients with intrinsic factor
929
E. Hauptmann

Download PDF
Requires Authentication Unlicensed

Licensed

An analogy of cobalamin membrane transport: an intestinal receptor for heme
933
R. Gräsbeck, I. Kouvonen, Margaretha Lundberg, R. Tenhunen and Hannele Yki-Järvinen

Download PDF
Requires Authentication Unlicensed

Licensed

A simplified method for quantitative determination of vitamin B₁₂ absorption
939
E. Hippe, P. Gimsing and N. H. Holländer

Download PDF
Requires Authentication Unlicensed

Licensed

Vitamin B₁₂ absorption studies with plastic whole body counter in patients with gastroenterological operation
945
R. Morishita and H. Uchino

Download PDF
Requires Authentication Unlicensed

Licensed

Affinity photo-release purification of cobalamin-binding proteins
949
D. Jacobsen and Y. Montejano

Download PDF
Requires Authentication Unlicensed

Licensed

Effect of pentagastrin in vitamin B₁₂ absorption in the guinea pig
955
M. Katz and E. Stopa

Download PDF
Requires Authentication Unlicensed

Licensed

Synthesis of cobalamin coenzymes in the rat and their secretion from the liver into plasma and bile
961
W. G. E. Cooksley, J. A. Owens, J. C. Linnell, H. A. Hussein, J. M. England and A. S. Tavill

Download PDF
Requires Authentication Unlicensed

Licensed

The pattern of cobalamins in human erythrocytes
967
Ebba Nexø and P. Gimsing

Download PDF
Requires Authentication Unlicensed

Licensed

Presence of sulfitocobalamin in cell extracts. Resolution and identification by SP-Sephadex C-25 cation exchange chromatography
971
James A. Begley and Charles A. Hall

Download PDF
Requires Authentication Unlicensed

Licensed

Mitochondrial cobalamins: types, sources, and functions with evidence of their noninvolvement in mitochondrial DNA synthesis
975
William S. Beck, Raphael Cohen and Jens Jorgensen

Download PDF
Chapter 7. PHYSIOLOGY AND PATHOLOGY OF VITAMIN B₁₂
Requires Authentication Unlicensed

Licensed

Studies on vitamin B₁₂ and ubiquinone
979
K. Folkers, J. Y. Choe, Y. Z. Kwen, S. Shizukuishi and S. Nishii

Download PDF
Requires Authentication Unlicensed

Licensed

Haematological aspects of cobalamin deficiency
991
J. M. England and J. C. Linnell

Download PDF
Requires Authentication Unlicensed

Licensed

The neurology of vitamin B₁₂ deficiency
1001
E. H. Reynolds

Download PDF
Requires Authentication Unlicensed

Licensed

Clinioal diseases related to defioienoies of vitamin B₁₂ transport proteins
1009
W. H. Hitzig, Marijke Fràter-Schröder and R. Seger

Download PDF
Requires Authentication Unlicensed

Licensed

Effects of methylaobalamin on peripheral neuropathies or experimentally-induced neuropathies
1017
M. Inada, M. Ogawa, H. Kameyama and F. Udaka

Download PDF
Requires Authentication Unlicensed

Licensed

Inherited deficiencies of the deoxyadenosylcobalamin (Ado-Cbl) dependent L-methylmalonyl-CoA mutase system: clinical and biochemical aspects
1019
R. Baumgartner and H. Wick

Download PDF
Requires Authentication Unlicensed

Licensed

An investigation of a possible role for coenzyme B₁₂ in ribonucleotide reduction in rabbit bone marrow
1025
Sarah Hopper

Download PDF
Requires Authentication Unlicensed

Licensed

Participation of cAMP in regulation of coenzyme B₁₂ dependent glycerol dehydratase synthesis from Klebsiella pneumoniae ATCC 85955
1029
A. Stroinski

Download PDF
Requires Authentication Unlicensed

Licensed

Carbon monoxide oxidation by Clostridia: evidence for the involvement of a corrinoid-like compound
1033
G. B. Diekert, E. G. Graf and R. K. Thauer

Download PDF
Requires Authentication Unlicensed

Licensed

The in vivo effects of nitrous oxide on human bone marrow - a morphological, biochemical and cell cycle study
1037
J. A. L. Amess, J. F. Burman, M. H. Cullen and D. L. Mollin

Download PDF
Requires Authentication Unlicensed

Licensed

Interconversion of cobalamins in human lymphocytes in vitro and the influence of nitrous oxide on synthesis of cobalamin coenzymes
1045
E. V. Quadros, Beverley Jackson, A. V. Hoffbrand and J. C. Linnell

Download PDF
Requires Authentication Unlicensed

Licensed

Studies on cobalamin and folate metabolism in rats exposed to nitrous oxide (N₂O)
1055
Rosemary Deacon, M. Lumb, M. Muir, Janet Perry, I. Chanarin, Barbara Minty, M. J. Halsey and J. F. Nunn

Download PDF
Requires Authentication Unlicensed

Licensed

Alterations in mammalian cells induced by inactivation of vitamin B₁₂ with nitrous oxide
1061
B. Reed, J. Dinn, S. McCann, P. Wilson, H. O’Sullivan, D. G. Weir and J. M. Scott

Download PDF
Requires Authentication Unlicensed

Licensed

High ascorbic acid intake and vitamin B₁₂ status in the rat
1065
Shirley Warnock Thenen

Download PDF
Requires Authentication Unlicensed

Licensed

Ability of megadoses of vitamin C to destroy vitamin B₁₂ and cobinamide and to reduce absorption of vitamin B₁₂ (with a note on B₁₂ radioassays)
1069
V. Herbert, L. Landau, R. Bash, S. Grosberg and N. Colman

Download PDF
Requires Authentication Unlicensed

Licensed

Interaction between methylcobalamin and some amino acids in single cell proteins
1079
J. Skupin, K. Waliszewski and B. Jaszewski

Download PDF
Requires Authentication Unlicensed

Licensed

Methylcobalamin and the modification of proteins in vitro
1085
S. J. Kanopkaite, J. A. Rackus, V. R. Kalnev and V. A. Stankevicius

Download PDF
Requires Authentication Unlicensed

Licensed

Deoxyadenosylcobalamin and the process of methylation of tRNA in model systems
1091
L. E. Taraseviciene and S. J. Kanopkaite

Download PDF
Requires Authentication Unlicensed

Licensed

The participation of coenzyme B₁₂ in the synthesis of DNA by Propionibacterium shermanii
1095
E. P. Jordan, N. V. Antoshkina and L. I. Vorobjeva

Download PDF
Requires Authentication Unlicensed

Licensed

Recent advances in cobalamin metabolism: abnormalities in coenzyme distribution in tumor development and in inherited metabolic disease
1101
J. C. Linnell and D. M. Matthews

Download PDF
Requires Authentication Unlicensed

Licensed

On some properties of the effect and metabolism of different cobalamins in tumor-bearing rats
1113
G. R. Brazenas, V. V. Bartkeviciene, A. M. Aleksiene, A. J. Alioniene, S. J. Kanopkaite and V. F. Zovyte

Download PDF
Requires Authentication Unlicensed

Licensed

Gastric cancer as a risk factor in pernicious anaemia
1119
L. Elsborg and J. Mosbech

Download PDF
Requires Authentication Unlicensed

Licensed

Interference with cobalamin metabolism and tumour growth by an analogue of methylcobalamin
1125
N. V. Myasishcheva, E. V. Quadros, Y. V. Vares and J. C. Linnell

Download PDF
Requires Authentication Unlicensed

Licensed

Vitamin B₁₂ requirement for replication of mouse leukemia L1210 cells: functional relevance to folate metabolism
1127
Katsuhiko Fujii, Tomohisa Nagasaki and F. M. Huennekens

Download PDF
Requires Authentication Unlicensed

Licensed

Vitamin B₁₂ and folia acid interrelations: a new look
1131
F. I. Haurani

Download PDF
Requires Authentication Unlicensed

Licensed

The effect of hypothyroidism on histidine oxidation and folate-dependent enzyme levels
1139
E. L. R. Stokstad, Margaret May-Sheng Chan, J. E. Watson, T. Brody and L. Jaenicke

Download PDF
Requires Authentication Unlicensed

Licensed

Cobalamin-dependent methionine synthesis and the regulation of the metabolism of activated folic acid derivatives in cultured human lymphoblasts
1145
H. Sauer

Download PDF
Requires Authentication Unlicensed

Licensed

Author and Citation Index
1149

Download PDF
Requires Authentication Unlicensed

Licensed

Subject Index
1171

Download PDF
Requires Authentication Unlicensed

Licensed

Collection of Photographs from the Symposium
1213

Download PDF

Publishing information

Pages and Images/Illustrations in book

eBook published on:

October 8, 2019

eBook ISBN:

9783111510828

Hardcover published on:

April 1, 1979

Hardcover ISBN:

9783110076684

Edition:

Reprint 2019

Pages and Images/Illustrations in book

Front matter:

17

Main content:

1212

Other:

Num. figs.

https://doi.org/10.1515/9783111510828

eBook ISBN: 9783111510828

Hardcover ISBN: 9783110076684

Keywords for this book

Vitamin B12; Woodward, Robert Burns; Corrinoide

Safety & product resources

Manufacturer information:
Walter de Gruyter GmbH
Genthiner Straße 13
10785 Berlin
productsafety@degruyterbrill.com

Vitamin B12

Overview

Topics

Table of contents

Frontmatter

Preface

CONTENTS

Introductory remarks for opening of 3rd European Symposium on vitamin B12

Introductory remarks. Historical perspectives on the isolation of crystalline vitamin B12

New and old problems in the structure analysis of vitamin B12

Synthetic vitamin B12

Chemical synthesis of corrinoids: current problems and recent advances

Recent studies on the synthesis of vitamin B12

New reactions of the chromophoric system of vitamin B12 derivatives

Structure and reactivity of the so-called stable yellow corrinoids

Concerning the structure of so-called yellow products obtained from naturally occurring metal-free corrinoids

Correlation of vitamin B12 methanolysis products with cobyrinic methyl ester amides prepared from hydrogenobyrinic acid amides

Preparation and X-ray structural analyses of a cobyrinic acid diamide and the corresponding rhodium analogue

Concerning a new corrinoid from municipal sludge

Steric course of the substitution by vitamin B12s as studied by 1H-NMR spectroscopy

Synthesis and X-ray analysis of a porphyrin-type Co(I)-complex

Stereochemistry of the formation and cleavage of the Co-C bond in a vitamin B12 model

The structure of superoxocobalamin, a single crystal ESR study

NMR studies of a novel form of vitamin B12

Circular dichroism study of organocobalamins

Concerning electronic, CD and ORD spectra of isomeric pairs of several (Co-methyl)-corrinoids

Some properties of cobalaminhexacyanoferrate

Temperature-jump kinetics of the "base-on" - "base-off" equilibrium of methylcobalamin

Electrochemistry of vitamin B12. Equilibria, kinetics and mechanisms in the B12a - B12r - B12s oxido-reduction

Electrochemistry of vitamin B12. Alkyl cobalamins and cobinamides

Recent biosynthetic researches on vitamin B12

Intermediary metabolism of cobyrinic acid biosynthesis

On the methylation process in cobyrinic acid biosynthesis

Biogenesis of tetrapyrrole compounds (porphyrins and corrinoids), and its regulation

Factor I ex Clostridium tetanomorphum: proof of structure and relationship to vitamin B12 biosynthesis

On the biosynthesis of the 5,6-dimethylbenzimidazole moiety of vitamin B12

The enzyme system of propionic acid bacteria transforming riboflavin into 5,6-dimethylbenzimidazole

Straight approaches to the nucleotide loop

Ribosomal proteins share in vitamin B12 biosynthesis

The ribosomal proteins L2, L5, L18 and L25 involved in vitamin B12 biosynthesis

Formation and role of vitamin B12 in Protaminobacter ruber and Rhizobium meliloti

Current status of the mechanism of action of B12 - coenzyme

A stereochemical approach to the diol dehydratase reaction

Coenzyme B12-dependent diol dehydratase - distribution and metabolic role in Enterobacteriaceae, enzymological properties and interaction with coenzyme B12

Adenosylcobalamin-dependent glycerol dehydratase interaction with substrates and their analogs

Glycerol dehydratase from Aerobacter aerogenes

The mechanism of action of methylmalonyl-CoA mutase as studied with isotope labelling and synthetic models

Recent studies on the mechanism of action of ethanolamine ammonia-lyase

Studies on the mechanism of reactions catalysed by ethanolamine ammonia-lyase

Steric course of the ethanolamine-ammonia lyase reaction

The chemical synthesis and coenzymatic properties of analogs of adenosylcobalamin in the ribonucleotide reductase reaction

Review of the EPR of B12r and B12 -dependent enzyme reactions

Vitamin B12: current problems and recent advances

The role of corrinoids in the total synthesis of acetate from C02

Mechanisms for B12 -dependent methylation

Nonenzymic models for the enigmatic coenzyme B12-dependent carbon-skeleton rearrangements

The mechanism of action of coenzyme B12

Model systems for adenosylcobalamin dependent enzymic reactions

Bridged cobaloximes as vitamin B12 models

Modified adenosylaobalamin: model systems for the active sites of corrinoid-dependent enzymes

Naturally occurring vitamin B12 antagonists and their potential therapeutic value

Structures of some vitamin B12 analogues and their biological as well as biochemical functions

Novel metal-free corrinoids and metal analogues

Preparation of ferribalamin, the Fe(III)-analogue of vitamin B12

Vitamin B12 assay: an evaluation of radiodilution assay using cobinamide to increase specificity

Effect of residual extract products and the type of binders (R or IF) on serum vitamin B12 levels by radioisotope dilution assay

Differential assay of cobamides in serum using R-protein radioisotopic dilution assay, E.coli and E.gracilis assays

Rapid determination of corrinoids by high performance liquid chromatography

Determination of the plasma cobalamins by one-dimensional thin-layer chromatography

Chemical quantitation of corrinoids

Enzymatic estimation of vitamin B12

Essential prerequisites for the analysis of cyanocobalamin in biochemically complex samples using radiometric competitive binding assays

Distribution of cobalamins in the animal body

Vitamin B12 in membrane mimetic agents - theoretical considerations and practical applications

Transport of vitamin B12 in Escherichia coli

The plasma transport of cobalamin (Cbl)

Soluble and membrane-bound vitamin B12 transport proteins

The origin and clinical implications of vitamin B12 binders - the transcobalamins

Large vitamin B12-binding proteins and complexes in human serum

Heterogeneity of antibodies against B12 binders in pernicious anaemia

Introductory remarks for opening of 3rd European Symposium on vitamin B₁₂

Introductory remarks. Historical perspectives on the isolation of crystalline vitamin B₁₂

New and old problems in the structure analysis of vitamin B₁₂

Synthetic vitamin B₁₂

Recent studies on the synthesis of vitamin B₁₂

New reactions of the chromophoric system of vitamin B₁₂ derivatives

Correlation of vitamin B₁₂ methanolysis products with cobyrinic methyl ester amides prepared from hydrogenobyrinic acid amides

Steric course of the substitution by vitamin B_12s as studied by ¹H-NMR spectroscopy

Stereochemistry of the formation and cleavage of the Co-C bond in a vitamin B₁₂ model

NMR studies of a novel form of vitamin B₁₂

Electrochemistry of vitamin B₁₂. Equilibria, kinetics and mechanisms in the B_12a - B_12r - B_12s oxido-reduction

Electrochemistry of vitamin B₁₂. Alkyl cobalamins and cobinamides

Recent biosynthetic researches on vitamin B₁₂

Factor I ex Clostridium tetanomorphum: proof of structure and relationship to vitamin B₁₂ biosynthesis

On the biosynthesis of the 5,6-dimethylbenzimidazole moiety of vitamin B₁₂

Ribosomal proteins share in vitamin B₁₂ biosynthesis

The ribosomal proteins L2, L5, L18 and L25 involved in vitamin B₁₂ biosynthesis

Formation and role of vitamin B₁₂ in Protaminobacter ruber and Rhizobium meliloti

Current status of the mechanism of action of B₁₂ - coenzyme

Coenzyme B₁₂-dependent diol dehydratase - distribution and metabolic role in Enterobacteriaceae, enzymological properties and interaction with coenzyme B₁₂

Review of the EPR of B_12r and B₁₂ -dependent enzyme reactions

Vitamin B₁₂: current problems and recent advances

The role of corrinoids in the total synthesis of acetate from C0₂

Mechanisms for B₁₂ -dependent methylation

Nonenzymic models for the enigmatic coenzyme B₁₂-dependent carbon-skeleton rearrangements

The mechanism of action of coenzyme B₁₂

Bridged cobaloximes as vitamin B₁₂ models

Naturally occurring vitamin B₁₂ antagonists and their potential therapeutic value

Structures of some vitamin B₁₂ analogues and their biological as well as biochemical functions

Preparation of ferribalamin, the Fe(III)-analogue of vitamin B₁₂

Vitamin B₁₂ assay: an evaluation of radiodilution assay using cobinamide to increase specificity

Effect of residual extract products and the type of binders (R or IF) on serum vitamin B₁₂ levels by radioisotope dilution assay

Enzymatic estimation of vitamin B₁₂

Vitamin B₁₂ in membrane mimetic agents - theoretical considerations and practical applications

Transport of vitamin B₁₂ in Escherichia coli

Soluble and membrane-bound vitamin B₁₂ transport proteins

The origin and clinical implications of vitamin B₁₂ binders - the transcobalamins

Large vitamin B₁₂-binding proteins and complexes in human serum

Heterogeneity of antibodies against B₁₂ binders in pernicious anaemia

The intraluminal phase of vitamin B₁₂ transport in humans

The significance of vitamin B₁₂ binders in the central nervous system

Adsorptive endocytosis of transcobalamin II-vitamin B₁₂ by isolated rat liver parenchymal cells

Intracelular transport of vitamin B₁₂ in enterocytes

A simplified method for quantitative determination of vitamin B₁₂ absorption

Vitamin B₁₂ absorption studies with plastic whole body counter in patients with gastroenterological operation

Effect of pentagastrin in vitamin B₁₂ absorption in the guinea pig

Studies on vitamin B₁₂ and ubiquinone

The neurology of vitamin B₁₂ deficiency

Clinioal diseases related to defioienoies of vitamin B₁₂ transport proteins

An investigation of a possible role for coenzyme B₁₂ in ribonucleotide reduction in rabbit bone marrow

Participation of cAMP in regulation of coenzyme B₁₂ dependent glycerol dehydratase synthesis from Klebsiella pneumoniae ATCC 85955

Studies on cobalamin and folate metabolism in rats exposed to nitrous oxide (N₂O)

Alterations in mammalian cells induced by inactivation of vitamin B₁₂ with nitrous oxide

High ascorbic acid intake and vitamin B₁₂ status in the rat

Ability of megadoses of vitamin C to destroy vitamin B₁₂ and cobinamide and to reduce absorption of vitamin B₁₂ (with a note on B₁₂ radioassays)

The participation of coenzyme B₁₂ in the synthesis of DNA by Propionibacterium shermanii

Vitamin B₁₂ requirement for replication of mouse leukemia L1210 cells: functional relevance to folate metabolism

Vitamin B₁₂ and folia acid interrelations: a new look