7 Exploring autism risk: a deep dive into graph neural networks and gene interaction data
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Danushka Bandara
Abstract
Autism spectrum disorder(ASD) has many genetic connections that can be represented in genetic association networks. These networks can be converted in graph data structure and also further examined using graph neural networks models to further examine the association these genes have with ASD. Our task shows that Graph Sage contains an 84.03 percent accuracy with 0.85 Area under the ROC curve. This model further examines the ability Graph Neural Network models have in the understanding of ASD association in relation to gene networks. The model was further examined using sensitivity of 0.96 and specificity of 0.94. The model successfully achieves a low false positive and negative rate making sure that the results for this association contain less chance of misclassification.
Abstract
Autism spectrum disorder(ASD) has many genetic connections that can be represented in genetic association networks. These networks can be converted in graph data structure and also further examined using graph neural networks models to further examine the association these genes have with ASD. Our task shows that Graph Sage contains an 84.03 percent accuracy with 0.85 Area under the ROC curve. This model further examines the ability Graph Neural Network models have in the understanding of ASD association in relation to gene networks. The model was further examined using sensitivity of 0.96 and specificity of 0.94. The model successfully achieves a low false positive and negative rate making sure that the results for this association contain less chance of misclassification.
Chapters in this book
- Frontmatter I
- Preface V
- Contents VII
-
Methods and instrumentation
- 1 Identifying and estimating outliers in time series with nonstationary mean through multiobjective optimization method 1
- 2 Using the intentionally linked entities (ILE) database system to create hypergraph databases with fast and reliable relationship linking, with example applications 21
- 3 Rapid and automated determination of cluster numbers for high-dimensional big data: a comprehensive update 37
- 4 Canonical correlation analysis and exploratory factor analysis of the four major centrality metrics 49
- 5 Navigating the landscape of automated data preprocessing: an in-depth review of automated machine learning platforms 71
- 6 Generating random XML 83
-
Applications and case studies
- 7 Exploring autism risk: a deep dive into graph neural networks and gene interaction data 105
- 8 Leveraging ChatGPT and table arrangement techniques in advanced newspaper content analysis for stock insights 121
- 9 An experimental study on road surface classification 145
- 10 RNN models for evaluating financial indices: examining volatility and demand-supply shifts in financial markets during COVID-19 165
- 11 Topological methods for vibration feature extraction 185
- 12 Dyna-SPECTS: DYNAmic enSemble of Price Elasticity Computation models using Thompson Sampling in e-commerce 215
- 13 Creating a metadata schema for reservoirs of data: a systems engineering approach 251
- 14 Implementation and evaluation of an eXplainable artificial intelligence to explain the evaluation of an assessment analytics algorithm for freetext exams in psychology courses in higher education to attest QBLM-based competencies 271
- 15 Toward a skill-centered qualification ontology supporting data mining of human resources in knowledge-based enterprise process representations 307
- Index 333
Chapters in this book
- Frontmatter I
- Preface V
- Contents VII
-
Methods and instrumentation
- 1 Identifying and estimating outliers in time series with nonstationary mean through multiobjective optimization method 1
- 2 Using the intentionally linked entities (ILE) database system to create hypergraph databases with fast and reliable relationship linking, with example applications 21
- 3 Rapid and automated determination of cluster numbers for high-dimensional big data: a comprehensive update 37
- 4 Canonical correlation analysis and exploratory factor analysis of the four major centrality metrics 49
- 5 Navigating the landscape of automated data preprocessing: an in-depth review of automated machine learning platforms 71
- 6 Generating random XML 83
-
Applications and case studies
- 7 Exploring autism risk: a deep dive into graph neural networks and gene interaction data 105
- 8 Leveraging ChatGPT and table arrangement techniques in advanced newspaper content analysis for stock insights 121
- 9 An experimental study on road surface classification 145
- 10 RNN models for evaluating financial indices: examining volatility and demand-supply shifts in financial markets during COVID-19 165
- 11 Topological methods for vibration feature extraction 185
- 12 Dyna-SPECTS: DYNAmic enSemble of Price Elasticity Computation models using Thompson Sampling in e-commerce 215
- 13 Creating a metadata schema for reservoirs of data: a systems engineering approach 251
- 14 Implementation and evaluation of an eXplainable artificial intelligence to explain the evaluation of an assessment analytics algorithm for freetext exams in psychology courses in higher education to attest QBLM-based competencies 271
- 15 Toward a skill-centered qualification ontology supporting data mining of human resources in knowledge-based enterprise process representations 307
- Index 333
