Serological responses in Norwegian adult volunteers to a meningococcal 15:P1.16 outer membrane vesicle vaccine (Phase II studies)

Chapters in this book

1. Frontmatter I
2. Preface V
3. Table of Contents VII
4. Epidemiology and Vaccines
5. Epidemiology and vaccines 3
6. Properties and epidemiology of 2 epidemic clones of serogroup A Neisseria meningitidis associated with African epidemics since 1980 5
7. Serotyping of N. meningitidis group B strains in China with monoclonal antibodies by whole cell ELISA 11
8. Group A meningococcus: Epidemiology and development of a protein polysaccharide conjugate vaccine 17
9. The Resolution of Clonal Types of Neisseria meningitidis by Pulsed Field Gel Electrophoresis 25
10. A three-year survey of Neisseria gonorrhoeae in Mexico 31
11. Genetic structure and epidemiology of serogroup B Neisseria meningitidis 37
12. Two epidemiological types of meningococcal infection incidence caused by serogroup B meningococci 43
13. Prevalence of group A (Clone II-2) Neisseria meningitidis in Scotland 49
14. The use of restriction fragment length polymorphisms for typing Neisseria meningitidis 55
15. Recent meningococcal epidemiology in Norway. Eight years of serotyping for strain characterization 57
16. Meningococcal meningitis Cairo - Egypt November 1983 - October 1989 63
17. Heterogeneity amongst B15P1-7.16 meningococci 69
18. Meningococcal disease in South Australia: 1971 through 1989 71
19. Epidemiology of Neisseria gonorrhoeae isolated in London 75
20. Changes of the age structure of meningococcal diseases in the Czech Republic 81
21. Multilocus genotypes determined by enzyme electrophoresis in Neisseria meningitidis strains isolated from meningitis patients in a nonepidemic situation in the Czech Republic 87
22. Nucleotide sequences and genetic diversity of the penA genes from penicillin sensitive and moderately penicillin resistant strains of Neisseria lactamica 93
23. Epidemiological markers of relatively penicillin G-resistant N. meningitidis isolated from patients in Spain (1985-1989) 99
24. The Role of Respiratory Infections in Epidemic Group A Meningococcal Meningitis 103
25. The utility of serological, biological and molecular typing schemes to differentiate N. gonorrhoeae isolates requiring proline, citrulline and uracil (PCU) for growth 111
26. Improving the early control of outbreaks of meningococcal disease 117
27. Meningococcal Infection in a Group of Canadian Travellers 123
28. Efficacy evaluation of the Cuban vaccine VA-MENGOC-BC^® against disease caused by serogroup B Neisseria meningitidis 129
29. Epidemiological behaviour of meningococcal disease in Cuba 135
30. Clonal and antigenic analyses of Neisseria meningitidis bacteria belonging to the ET37 complex isolated from Mali and elsewhere 141
31. Comparison of monoclonal antibodies for serotyping and subtyping of Neisseria meningitidis 147
32. Epitopes on the Meningococcal Class 1 Protein. 153
33. The clonal population structure and serosubtypes of Neisseria meningitidis serogroup A isolated in China 159
34. Epidemiological features of epidemic cerebrospinal meningitis in China 165
35. Immunogenicity and Vaccine Development
36. Vaccine development 175
37. Human and Animal Immune Response to Homologous and Heterologous Meningococcal 70 Kilodalton Iron Regulated Outer Membrane Protein. 177
38. Specificity of Antibody response to Group C meningococcal Polysaccharide among vaccinees and carriers 183
39. Immunological Properties of Monoclonal Antibodies to the N-Propionyl Derivative of Group B Meningococcal Polysaccharide 187
40. Sequence Comparisons of Class 1 Genes from Neisseria meningitidis and a Folding Model of the Class 1 Protein 193
41. Antigenic homology between the 65kDa heat shock protein of Mycobacterium tuberculosis, GroEL of E. coli, and proteins of Neisseria gonorrhoeae expressed during infection. 199
42. Western blot study of Neisseria! antigens reactive with sera from cases and carriers of Neisseria meningitidi 205
43. Human antibody to the class 1 outer membrane protein and H8 lipoprotein of Neisseria meningitidis 209
44. Structural Orientation and Antigenic Analysis of the Class 2 and Class 3 Outer Membrane Proteins of Neisseria meningitidis 213
45. Identification and expression in E.coli of a conserved surface epitope of pathogenic Neisseriae 219
46. Therapeutic efficacy of monoclonal antibodies to Class 1 and Class 2 Proteins against meningococcal infection in infant rats 225
47. Antibody responses in six volunteers immunized with a gonococcal Protein I vaccine 229
48. Immunobiology of Neisseria porin proteins and mapping of epitopes with vaccine potential 235
49. Serological responses in Norwegian adult volunteers to a meningococcal 15:P1.16 outer membrane vesicle vaccine (Phase II studies) 241
50. Identification and Characterization of Conserved Outer Membrane Proteins of Neisseria gonorrhoeae 247
51. Molecular cloning and expression of a 63 kDa gonococcal stress protein in E.coli 253
52. Development of Liposomal Vaccine on the Basis of Neisseria meningitidis Lipooligosaccharide 259
53. Relative bactericidal activity of IgG antibodies against outer membrane complexes from meningococci, as a function of vaccine type, dose and time after vaccination 265
54. Efficacy of Human Monoclonal Antibodies to the Group B Polysaccharide of Neisseria Meningitidis in Experimental Infant Rat Model 271
55. Immunomodulating Complex of Oligopeptide Antigen and Liposomal Form of Neisseria meningitidis Lipooligosaccharide 277
56. Construction of a Defined Auxotrophic Mutant of Neisseria gonorrhoeae for use as a Human Vaccine. I. Cloning, Mapping and Mutagenesis of aroA. 283
57. The use of PCR to study the class 1 outer membrane protein of Neisseria meningitidis 289
58. The class 1 outer membrane protein of Neisseria meningitidis: prediction of topology and construction of a multivalent vaccine strain 295
59. Immunogenicity of meningococcal LPS derived oligosaccharide-protein conjugates using isolated and synthetic oligosaccharides 301
60. The Expression of an Escherichia coli OmpA - Neisseria meningitidis Class 1 Fusion Protein 307
61. Gonococcal Porin Vaccine 313
62. T-cell Recognition of Neisseria Meningitidis Outer Membrane Proteins 321
63. Lipopolysaccharide-related Subjects
64. Neisserial lipopolysaccharide 329
65. Protective activity of detoxified lipooligosaccharides of Neisseria meningitidis serogroups A and B in mice 331
66. Restoration of Neisseria gonorrhoeae Serum Resistance by Cytidine 5' Monophospho-N-acetylneuraminic Acid Depends On the Quality of the Lipopolysaccharide 337
67. Pseudomonas pyocin and Neisseria gonorrhoeae: Investigations into the mechanism of gonococcal lipooligosaccharide variant selection 343
68. The surface polysaccharide seen on Neisseria gonorrhoeae after treatment with CMP-NANA contains sialyl groups. 349
69. Relationship of sialylation of lipooligosaccharide (LOS) of N. gonorrhoeae to cleavage of C3 and serum resistance 353
70. LPS phase-variation & its role in the virulence of Haemophilus influenzae 359
71. Gonococci in most urethral exudates are sialylated: neuraminidase changes serum resistance to susceptibility. 367
72. Role of DNA methylatìon in the growth of Neisseria gonorrhoeae 373
73. Pathogenesis and surface antigens shared by Haemophilus ducreyi and Neisseria gonorrhoeae 379
74. Regulation of the addition of 0-side chains on lipooligosaccharide in Neisseria gonorrhoeae 385
75. Some Effects of LOS and Opa on Surface Properties of Gonococci 391
76. Lipopolysaccharides of Haemophilus and Neisseria: Antigenic and structural similarities 397
77. Pili and Iron-inducible Proteins
78. The Mechanisms of Genetic Variation of Gonococcal Pili. Iron-Inducible Proteins of Neisseria 405
79. Interaction Between Iron Regulated Outer Membrane Protein Of Neisseria meningitidis and Human Transferrin Binding Activity 415
80. Gonococcal unprocessed prepilin is transported to E.coli inner membrane 419
81. Illegitimate Recombination and Gonococcal Pilin Gene Variation 425
82. Translational Frameshifting in pilC Encoding a Gonococcal Outer Membrane Protein Results in Pili Phase Variation 431
83. Iron and meningococcal disease. Serum lactoferrin in meningococcal disease patients and controls 435
84. Control of pilin gene expression in Neisseria gonorrhoeae by environmental factors 441
85. Antigen Variation and Transformation-Mediated Horizontal Exchange in the Pathogenic Neisseria 447
86. Structure, Function, and Regulation of the Iron-binding Protein, Fbp 453
87. Heterogeneity of Iron-Regulated Meningococcal 70 kDa and 98 kDa OMPs 459
88. Repeated elements in silent pil sequences found upstream of the class 1 meningococcal pilE gene 465
89. Iron acquisition of systemic and nonsystemic meningococcal isolates 469
90. Analysis of the Pilin Gene Inversion Region of Moraxella lacunata 475
91. Iron Acquisition in Neisseria: Bacterial Receptors for Human Transferrin and Human Lactoferrin in Neisseria meningitidis 481
92. Pilin gene regulator PiLA fulfils a dual role in Neisseria gonorrhoeae 487
93. Molecular Genetics
94. The Coding Repeat Region of Gonococcal Opa Genes Forms Unusual DNA Conformations in E. coli 497
95. High Frequency Mobilization of IncQ Plasmids from E. coli to Neisseria 503
96. Mobilization of naturally-occurring gonococcal penicillinase-producing plasmids by different conjugative plasmids 511
97. Molecular Mechanisms of Capsule Expression in Neisseria meningitidis 517
98. Genetic Characterization of Neisserial Restriction / Modification systems 523
99. Genetic transformation of Neisseria gonorrhoeae using electroporation 527
100. Characterization of the 25.2 Mda Tet M-Containing Plasmids 533
101. Class 5 proteins and opa genes in clones IV-1 and III-l of Neisseria meningitidis serogroup A 539
102. Specificity in Neisseria gonorrhoeae Transformation: Implications for Cell-surface Variation 545
103. Tn916 Mutagenesis of Neisseria meningitidis and Neisseria gonorrhoeae 551
104. Pathogen-host Interactions
105. Pathogen-Host Interactions: An Overview 559
106. Enhancement of the Invasive Ability of Neisseria gonorrhoeae by Contact with HecIB, an Adenocarcinoma Endometrial Cell Line 567
107. Ability of Cells of the Human Fallopian Tube to Act as Antigen Presenting Cells 573
108. Identification of a Human Neutrophil Receptor for Gonococcal Outer Membrane Protein PII 579
109. Pilin variation in Neisseria gonorrhoeae and modulation of cellular adherence 585
110. Evidence for the in vivo modification of the gonococcal Pan 1 protein 591
111. Gerard T. Hoehn and Virginia L. Clark 597
112. Studies on natural local immunity in gonorrhea: ELISA reactivities of female local secretions with outer membranes of Neisseria gonorrhoeae 603
113. A study on meningococcal colonization of epithelium 609
114. The role of Opa in adherence of gonococci to HEC-l-B cells and to human fallopian tube tissues 615
115. Possible Mechanisms of Serum Resistance of Neisseria gonorrhoeae from Disseminating Infections 621
116. Effects of lipopolysaccharide from N. meningitidis on human granulocyte lysis and chemiluminescence 627
117. Antigonococcal Action of Synthetic Peptides from Huaan Proteases Cathepsin G and Granzyme B 633
118. How to Measure Gonococcal Invasion 639
119. Interactions of pathogenic Neisseria with Human endothelial cells in vitro 645
120. Fates of LOS and the Outer Membrane Proteins P.IA and Opa in Early and Late Events of Gonococcal Infection of Epithelial Cells 651
121. Clinical Epidemiology and other Subjects
122. Meningococcal Disease in the USSR in Patients with Deficiences in Late Complement Components 659
123. Chemoprophylactic Suppression of Endemic Carriage of Group B Serotype 4 Neisseria meningitidis in a Kibbutz Community 665
124. Antibody Response to Meningococcal Infection in Late Complement Component Deficient Individuals 671
125. Therapeutic application of hyperimmune Gammaglobulin against B meningococcal disease in children 679
126. A clinical-epidemiological study of Neisseria meningitidis isolated from urogenital specimens 685
127. Oxidant Stress, DNA Repair, and Antioxidant Defenses in Neisseria gonorrhoeae 689
128. N. meningitidis infections in South African complement component C6 deficient patients; Studies of methods of prophylaxis and of the organisms isolated 701
129. Colonization of the Interface between the Agar and the Petri Dish by Moraxella bovis: New Variant Expression is Inversely Related to Colonization Rate 707
130. Comparison between Neisseria gonorrhoeae and Bacteroides species. Different Effects of CMP-NANA for Conversion to Resistance to Complement in Serum and Toxicity of CMP 715
131. Maintenance and Functions of Sulfhydryls in Neisseria gonorrhoeae 721
132. Penicillin permeability in Neisseria gonorrhoeae 727
133. Factors Associated with Cellular Invasion of Neisseria gonorrhoeae 733
134. Author Index 741
135. Subject Index 747