Resistance of the Rat to Certain Specific Limb Teratogens

Chapters in this book

1. Frontmatter I
2. Preface V
3. Introduction VII
4. Table of Contents IX
5. I. Basic Problems of Normal Limb Development
6. Developmental Control of Spatial Sequences of Structures 1
7. Antero-Posterior Positional Signalling in the Developing Chick Limb 11
8. Morphological and Histochemical Aspects of the Subridge Mesoderm in Avian and Mammalian Limb Buds 19
9. Control by the Posterior Border of Cell Death Patterns in Limb Bud Development of Amniotes: Evidence from Experimental Amputations and from Mutants 27
10. Characterization of Embryonic Cholinesterase in the Chondrogenic Core of the Chick Limb Bud and Demonstration of a Specific Acetylcholine Receptor 35
11. Limb Chondrogenesis: Interactions between Ectoderm and Mesoderm 43
12. Role of the Ectoderm in Limb Development of Normal and Mutant Mouse (Disorganization, Pupoid Foetus) and Fowl (Talpid³) Embryos 53
13. Origin, Distribution and Determination of Chick Limb Mesenchymal Cells 67
14. The Concept of a Myogenic Cell Line in Developing Avian Limb Buds 79
15. On the Formation of Muscular Pattern in the Chick Limb 89
16. Muscle Development during Normal and Disturbed Skelettogenesis 99
17. Developmental Properties of the Foot Integument in Avian Embryos 109
18. The Contrast between Mouse and Ferret Limb Buds in Culture - Possible Advantages of Comparing Results from a Limb Culture System with Whole Embryo Explantation 117
19. Transfilter Interaction of the Zone of Polarizing Activity with the Apical Ectodermal Ridge and the Distal Mesenchyme in the Chick Embryo Wing Bud in Ovo 129
20. Simulation of Steps of Limb Skelettogenesis in Vitro 137
21. Effects of Surface Coat Influencing Substances on the Limb Bud Blastema in Vitro 153
22. Effects of Surface Coat Influencing Substances on the Limb Bud Blastema in Vitro Bernd Zimmermann 163
23. The Occurrence of Unilateral Abnormality of the Limb Induced by the Teratogen 6-Aminonicotinamide 171
24. Ascorbic Acid Content of Limb Buds at Different Stages of Mammalian Embryonic Development 183
25. II. EXPERIMENTAL EMBRYOLOGY AND TERATOLOGY
26. A. Experimental Embryology
27. Abnormalities along the Proximo-Distal Axis of the Chick Wing Bud: The Effect of Surgical Intervention 191
28. The Effects of X-lrradiation on Limb Development 199
29. Effects of Matrix Influencing Substances on Chondrocyte in Monolayer Culture 207
30. The Influence of Nerve Supply in Limb Development 223
31. Defective Innervation and Defective Limbs: Causes and Effects in the Developing Chick Wing 235
32. B. General Aspects of Teratology
33. On the Problem of Phase Specificity in Limb Teratogenesis 243
34. The Problem of Growth Retardation 253
35. Bilaterally Symmetric and Asymmetric Realization of Limb Malformations 259
36. Immunofluorescent Microscopic Investigations of Intercellular Substances during Limb Development 273
37. An Analysis of the Asymmetric Response of the Developing Limb to Embryotoxic Agents 295
38. Resistance of the Rat to Certain Specific Limb Teratogens 301
39. Observations on Human Digits 'In Vitro' and its Possible Role in Evaluating Teratogens 307
40. The Effects of Sodium Salicylate, Cytosine Arabinoside, and Eserine Sulphate on Rat Limb Buds in Culture 325
41. C. Effects of Teratogenic Agents
42. The Transplacental Effects of Vitamin D Metabolites and Corticosteroids on the Long Bones of Rat and Mice Fetuses 339
43. The Effect of Cytosine-Arabinoside on Limb Morphogenesis in the Mouse 355
44. Mechanisms of Limb Development Revealed by the Teratogenic Activity of Nicotinamide Analogues 363
45. Analysis of Radiographs in Reproduction Toxicology by Means of Densitometry and Planimetry 373
46. Limb Malformations Induced in the Rat by Amniotic Puncture 383
47. The Effect of Sodium Salicylate on Limb Development 393
48. a,a'-Dipyridyl Teratogenicity in the Rat 403
49. D. Limb Defects in Man
50. Approaches to Classification of Limb Defects 413
51. Formal Genesis of Syndactyly 417
52. Thalidomide and the Neural Crest 431
53. List of Participants 449
54. Index 452