Lymphocyte Activation and Differentiation: Fundamental and Clinical Aspects. Proceedings of the 18th International Leucocyte Culture Conference. La Grande Motte, France, June 19–24, 1987

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Lymphocyte Activation and Differentiation

Fundamental and Clinical Aspects. Proceedings of the 18th International Leucocyte Culture Conference. La Grande Motte, France, June 19–24, 1987

Edited by: J. C. Mani and J. Dornand

Language: English

Published/Copyright: 1988

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Frontmatter Publicly Available Download PDF	I
PREFACE Publicly Available Download PDF	V
CONTENTS Publicly Available Download PDF	VII
INTRODUCTION
Fundamental and Clinical Aspects of Lymphocyte Activation and Differentiation J. C. Mani and J. Dornand Requires Authentication Unlicensed Licensed	1
PLENARY LECTURE
Oncogenes and Multistep Carcinogenesis D. Stehelin Requires Authentication Unlicensed Licensed	5
SYMPOSIA BIOCHEMICAL AND CELLULAR ASPECTS OF LYMPHOCYTE ACTIVATION
Biochemical and Molecular Events Controlled by Lymphoid and Myeloid Growth Factors W. L. Farrar, D. K. Ferris and A. Harel-Bellan Requires Authentication Unlicensed Licensed	17
PGE2 Inhibition of Human T Lymphocytes Proliferation: Regulatory Effect of PGE2 on the Intra-Cellular Signaling Pathways S. Chouaib, J. Bertoglio and D. Fradelizi Requires Authentication Unlicensed Licensed	27
Structure-Function Relationships for the Interleukin 2 Receptor R. J. Robb Requires Authentication Unlicensed Licensed	35
Monovalent Cation Fluxes as Regulators of Critical Nuclear Events in Lymphocyte Activation: Mirror Image Processes in Differentiation and Proliferation J. G. Kaplan, K. V. S. Prasad, B. Sahai and A. Severini Requires Authentication Unlicensed Licensed	45
Diacylglycerol, Calcium, cAMP and cGMP Mediate Qualitatively Distinct Protein Kinase C Translocation Events in Normal B Lymphocytes J. C. Cambier and Z. Z. Chen Requires Authentication Unlicensed Licensed	57
Phosphorylation of Prosolin and Leucocyte Growth Regulation H. L. Cooper and R. Braverman Requires Authentication Unlicensed Licensed	67
DIFFERENTIATION OF T AND B LYMPHOCYTES
Regulation of Human B Cell Function J. L. Ambrus, H. Goldstein, K. R. Young, P. McFarland, T. Nakagawa, N. Nakagawa, E. Brown, F. Uckun, A. Tenner, M. Peters, N. Witzel, H. Mostowski and A. S. Fauci Requires Authentication Unlicensed Licensed	73
The Role of Lymphokines in the Immunoglobulin Class Switch C. M. Snapper and W. E. Paul Requires Authentication Unlicensed Licensed	83
Mouse and Human B Cell Activating Factors J. Theze, C. Roth, A. Diu, D. Jankovic, M. Körner, O. Abehsira-Amar, J. L. Moreau, M. Fevrier and M. L. Gougeon Requires Authentication Unlicensed Licensed	97
Molecular Cloning of the Murine T11 (CD2) cDNA P. H. Sayre, L. K. Clayton, E. L. Reinherz and J. Novotny Requires Authentication Unlicensed Licensed	111
Antigen Expression and Proliferative Activity during B and T Cell Development D. Campana and G. Janossy Requires Authentication Unlicensed Licensed	123
MOLECULAR BIOLOGY OF LEUCOCYTES (ANTIGENS, RECEPTORS, INTERLEUKINS)
The Molecular Biology of the Multisubunit Interleukin-2 Receptor T. A. Waldmann, C. Goldman and M. Tsudo Requires Authentication Unlicensed Licensed	133
Expression and Rearrangement of T Cell Receptor Genes in Human Leukemic T Cell Lines N. Kimura, R.-P. Du and T. W. Mak Requires Authentication Unlicensed Licensed	143
The Human T-Cell Rearranging γ Genes (TRGγ) M. -P. Lefranc, A. Forster and T. H. Rabbitts Requires Authentication Unlicensed Licensed	153
Immunoglobulin Gene Expression M. S. Neuberger, G. P. Cook, J. O. Mason, C. Milstein, S. Pettersson, W. Reik, M. J. Sharpe, R. Sitia, M. A. Surani, K. Weston and G. T. Williams Requires Authentication Unlicensed Licensed	159
Structure and Expression of Mouse Fcy Receptor II (FcyRII) J. Even, N. Varin, M. Daeron, C. Bonnerot, W. H. Fridman, P. M. Hogarth, E. Witort and L. Bonadonna Requires Authentication Unlicensed Licensed	165
VIRUS-INDUCED LYMPHOCYTE DYSFUNCTIONS
The Impact of the Presence of EBV on the Interaction of B Cell Lines with T Lymphocytes E. Klein and G. Klein Requires Authentication Unlicensed Licensed	175
Induction of B Cell Activation Markers by Epstein-Barr Virus A. Calender, M. Billaud and G. Lenoir Requires Authentication Unlicensed Licensed	183
Production of Interleukin-1 (IL1) by EBV-Infected Cells T. Tursz, C. Bensimon, P. Busson, Y. Mahe and H. Wakasugi Requires Authentication Unlicensed Licensed	191
DNA-Mediated Gene Transfer of Epstein-Barr Virus Receptor onto Murine Fibroblasts J. F. Cantaloube, P. Poncelet, A. Calender, G. Lenoir and M. Piechaczyk Requires Authentication Unlicensed Licensed	201
ACCESSORY CELL FUNCTIONS
Modulation of IL1 Receptor Expression by IL1, Prostaglandins and Glucocorticoids J. J. Oppenheim, T. Akahoshi, K. Matsushima and G. Tosato Requires Authentication Unlicensed Licensed	209
Tumor Necrosis Factors: Modulation of Synthesis and Biological Activities G. H. W. Wong and D. V. Goeddel Requires Authentication Unlicensed Licensed	217
Analysis of the Structure and Function of Immunectin J. Schwartz, G. Freeman, R. Patarca, R. Singh, S. Zolnay, G. Orfanos, V. Anderson, S. J. Galli, T. Durfee, F. Blattner and H. Cantor Requires Authentication Unlicensed Licensed	227
Natural Effector Cells of the Intestinal Epithelium: Ontogeny, Function, and Regulation J. R. Klein and M. D. Howell Requires Authentication Unlicensed Licensed	235
Analysis of Ia-Transfected Fibroblasts: Antibody and T Cell Recognition Sites Segregate with the 31 Domain of the E3 Polypeptide Chain N. Rebai, F. Bekkhoucha, D. Emilie, M. McMillan, M. Pierres and B. Maiissen Requires Authentication Unlicensed Licensed	245
WORKSHOPS WORKSHOP A. GROWTH AND DIFFERENTIATION FACTORS
Inhibition by Cyclosporin A of the IL2 Dependent Autocrine Growth in a Human Tumor T Cell Line and Fate of IL2 Receptors after Endocytosis A. Dautry-Varsat, V. Duprez, A. Hemar and M. Ferrer Requires Authentication Unlicensed Licensed	259
Interleukin B, a B Cell-Derived Lymphokine P. Del Guercio Requires Authentication Unlicensed Licensed	263
Induction and Enhancement of Lymphokine Gene Expression in Human T Cell Clones Transfected with HTLV-I pX cDNA R. De Waal Malefijt, H. Yssel, H. Spits, J. E. De Vries, S. Miyatake, T. Yokota, K. I. Arai, M. Seiki and M. Yoshida Requires Authentication Unlicensed Licensed	267
Evidence for a Human B Cell Activating Factor Acting on Resting B Lymphocytes A. Diu, M. Fevrier, J. L. Moreau, M. L. Gougeon, J. Theze and E. L. Reinherz Requires Authentication Unlicensed Licensed	271
Splicing Intermediates of the IL-2 Receptor (p55 Subunit) P. Froussard, P. Chastagner, J. Theze and S. Longacre Requires Authentication Unlicensed Licensed	275
The Role of Plasminogen Activator in Regulating T Cell Proliferation and Interferon Production P. Gladstone, M. Leahy and C. A. Spooner Requires Authentication Unlicensed Licensed	279
Membrane and Soluble IL2-R Produced by Human T Cell Clones: A Comparative Study Y. Jacques, B. Le Mauff, F. Boeffard, A. Godard and J. P. Soulillou Requires Authentication Unlicensed Licensed	287
Phenotype and Cytokines Production by Human Myeloma Cell Lines B. Klein, M. Jourdan, C. Dupperay and R. Bataille Requires Authentication Unlicensed Licensed	291
B + Null Cell-Derived Prothymocyte Differentiating Activity (PTDA): Biological Properties and Physicochemical Characterization J. C. Lecron, M. D. Mossalayi, L. Sutton, J. Gombert, J. Tanzer and P. Goube De Laforest Requires Authentication Unlicensed Licensed	297
TDM-Activated Macrophages Produce a Cytostatic Factor Distinct from TNFα, IFNα,β, and IL-1 M. Lepoivre, G. Lemaire and J. F. Petit Requires Authentication Unlicensed Licensed	301
Characterization of a Factor Produced by Human Alloreactive T Cell Clones J. F. Moreau, H. Gascan, A. Godard, M. Bonneville and J. P. Soulillou Requires Authentication Unlicensed Licensed	305
WORKSHOP B. MECHANISMS OF AUTOIMMUNITY
Effector Mechanisms of Autoimmune Diseases J. F. Bach Requires Authentication Unlicensed Licensed	309
T Cell Response to Myelin Basic Protein in Healthy Subjects and Multiple Sclerosis Patients M. A. Bach, E. Tournier-Lasserve and G. Hashim Requires Authentication Unlicensed Licensed	323
Active T Cell Regulation of Autoimmune Responses in Autoimmune and "Nonautoimmune" Spleen Cell Populations C. E. Calkins, R. D. Miller, S. A. Cochran, A. L. Rothermel, J. S. Moore and M. J. Caulfield Requires Authentication Unlicensed Licensed	327
Interleukin-2 Receptor Targeted Immunotherapy of Autoimmune Diseases: Treatment Strategies for Type I Diabetes T. Diamantstein, A. Dunger, I. Kloting, B. Kuttler, H. D. Volk, H. J. Hahn and R. V. Baehr Requires Authentication Unlicensed Licensed	331
Protection of Non-Obese Diabetic (NOD) Mice from Insulitis by Neonatal Injection of F₁ Spleen Cells A. R. Hayward, P. Chantler and E. Simpson Requires Authentication Unlicensed Licensed	335
WORKSHOP C. ONCOGENES AND LEUCOCYTE TRANSFORMATION
Complex Transcriptional Regulation of Nuclear Proto Oncogenes: Existence of a Block to Elongation in C-Myc and C-Fos Genes J. M. Blanchard, M. Piechaczyk, P. Fort, N. Mechti, H. G. Suarez, B. Lebleu and P. Jeanteur Requires Authentication Unlicensed Licensed	339
Determinants of C-Fos and C-Myc mRNAs Instability A. Bonnieu, M. Piechaczyk, P. Fort, J. Rech, J. M. Blanchard and P. Jeanteur Requires Authentication Unlicensed Licensed	345
Cloning and Functional Analysis of the Human C-fms Gene P. Dubreuil, M. Courcoul, D. Birnbaum, J. Planche, M. J. Pebusque, P. Mannoni and F. Birg Requires Authentication Unlicensed Licensed	351
Effects of Proliferative (Interleukin, Colony Stimulating Factors) and Antiproliferative (Cyclic AMP, Interferon) Signals on Gene Expression in Myeloid and Lymphoid Cell Lines A. Harel-Bellan and W. L. Farrar Requires Authentication Unlicensed Licensed	355
The Progession to Tumourigenes is Following Transformation of Murine Myelomonocytic Cell by V-Myc G. Symonds, P. B. Rowe, Y. Takayama, P. Stapleton, A. Bruskin and J. M. Bishop Requires Authentication Unlicensed Licensed	359
HTLV-I Infection of a Human Antigen Specific Proliferating/Cytotoxic T Cell Clone Results in a Loss of Cytotoxicity but does not Affect the T Cell Receptor H. Yssel, J. E. De Vries, H. Spits, M. Due Dodon and L. Gazzolo Requires Authentication Unlicensed Licensed	363
WORKSHOP D. EXPERIMENTAL MODELS OF IMMUNOMODULATION
Roles of Monokines in the Nonspecific Host Defence Stimulated by Exogenous Agents M. Parant Requires Authentication Unlicensed Licensed	367
Enhancement of the Immune Response Using a Synthetic B-Lymphocyte Mitogen Covalently Linked to Antigens T. Böltz, W. G. Bessler, G. Jung, K. H. Wiesmüller and J. Metzger Requires Authentication Unlicensed Licensed	379
Effects of in vivo Treatment of Mice with Anti-Murine T3 Antibody: Suppression of Transplantation Responses R. Hirsch, O. Leo, D. H. Sachs and J. A. Bluestone Requires Authentication Unlicensed Licensed	383
Gamma-Interferon Protects Listeria-Susceptible BALB/c Mice from Lethal Listeriosis without Affecting the Development of Protective Immunity A. F. Kiderlen and M. L. Lohmann-Matthes Requires Authentication Unlicensed Licensed	387
Effect of a Lipophilic Muramylitri peptide on Gamma-Interferon Induced Major Histocompatibility Antigen (MHC) and Leu-M3 Antigen Changes in Human Monocytes R. Landmann, M. Wesp and P. Dukor Requires Authentication Unlicensed Licensed	393
Effect of Cyclosporin A (CsA) on the Induction of Memory T Lymphocytes I. Motta, B. Shidani and P. Truffa-Bachi Requires Authentication Unlicensed Licensed	399
Modulation by Cyclosporin A (CsA) of the Immune System of Mice Infected with Lymphocytic Choriomeningitis Virus (LCMV) B. Shidani, M. -F. Saron, J. -C. Guillon and P. Truffa-Bachi Requires Authentication Unlicensed Licensed	403
Modulation of Lymphocyte Activation in vitro by a Soluble Placental Factor A. Skibin, S. Segal and M. R. Quastel Requires Authentication Unlicensed Licensed	407
The Role of Interleukins and the Interleukin-2 Receptor in the Pathogenesis of Murine Cutaneous Leishmaniasis W. Solbach, M. Lohoff, C. Gunther, H. Streck, M. Röllinghoff and T. Diamantstein Requires Authentication Unlicensed Licensed	413
In vitro Studies of Synthetic Glycolipids: A New Class of Compounds with Immunomodulating Activity K. G. Stlinkel, O. Lockhoff, G. Streissle, V. Klimetzek, A. Paessens and H. D. Schlumberger Requires Authentication Unlicensed Licensed	421
Immunotoxicity Studies of PCB (Aroclor 1254) in the Adult Rhesus (Macaca mulatta) Monkey H. Tryphonas, S. Hayward, L. O’Grady, J. C. K. Loo, D. L. Arnold, F. Bryce and Z. Z. Zawidzka Requires Authentication Unlicensed Licensed	427
Human Cytomegalovirus Induces Alterations in Mixed Lymphocyte Reactions C. L. Wright, S. J. Forman, J. A. Zaia and K. G. Blume Requires Authentication Unlicensed Licensed	433
WORKSHOP E. IMMUNODEFICIENCIES
Immunological Aspects of AIDS and HIV Infection M. Seligmann Requires Authentication Unlicensed Licensed	437
Studies Regarding the Interaction of the T4 (CD4) Molecule with the Envelope Protein gp120 of the Human Immunodeficiency Virus (HIV) D. K. Ferris, D. Littmann and W. L. Farrar Requires Authentication Unlicensed Licensed	445
Low Level Re-Expression of the Silent MHC Class-II Genes in the Lymphoblasts from Patients with the HLA-Class II Deficient SCID A. Lisowska-Grospierre, A. Guyot, M. T. Dimanche, B. Mach and C. Griseelli Requires Authentication Unlicensed Licensed	449
Adenylate Cyclase and 5'Nucleotidase Activities of Peripheral Blood Mononuclear Cells is Psoriasis J. C. Mani, A. Chocquet, J. C. Bonnafous, J. Dornand, M. Andary, J. Clot and J. J. Guilhou Requires Authentication Unlicensed Licensed	453
WORKSHOP F. NATURAL KILLER CELLS
Natural Killer Cells E. Klein Requires Authentication Unlicensed Licensed	465
Characterization and Population Kinetics of Liver-Associàted Large Granular Lymphocytes (Natural Killer Cells) L. Bouwens and E. Wisse Requires Authentication Unlicensed Licensed	469
Modulation of Lymphonkine Activated Killer Activity of Lymphocytes Isolated from Human Peripheral Blood and Bone Marrow by Recombinant IL4 C. G. Figdor, E. Wierenga, J. E. De Vries and H. Spits Requires Authentication Unlicensed Licensed	473
Inhibition of Human Natural Killer Cells by Resistant Target Cells M. K. Heiskala Requires Authentication Unlicensed Licensed	479
Changes in Gene Expression Associated with Activation or Inhibition of Natural Killer Function J. Kornbluth and R. Hoover Requires Authentication Unlicensed Licensed	483
Fibronectin Expression by Endogenous and Activated NK Cells S. Morrone, S. Scarpa, R. Testi, G. D’Orazi, A. Gismondi, A. Punturieri, M. Piccoli, L. Frati, A. Modesti and A. Santoni Requires Authentication Unlicensed Licensed	489
Cytolytic Potential of CD3⁺4^-8^- T Cells with Differently Organized T Cell Receptor Y Chains R. J. Van De Griend, R. L. H. Bolhuis, J. Borst, S. L. Ang, D. Hafler and J. G. Seidman Requires Authentication Unlicensed Licensed	493
WORKSHOP G, DIFFERENTIATION AND ACTIVATION OF T LYMPHOCYTES
CD1a Molecules Form Intermolecular Complexes with HLA Class I Molecules or Other CD1 Molecules on Normal Human Thymus Cells M. Amiot, H. Dastot, A. Bernard and L. Boumsell Requires Authentication Unlicensed Licensed	499
The CD2 Pathway of Activation. Epitope Requirements, Linkage to Other Surface Molecules and Early Biochemical Events D. Olive, A. Pierres, C. Cerdan, M. Bagnasco and C. Mawas Requires Authentication Unlicensed Licensed	511
A T-Cell Surface Molecule Different from CD2 is Involved in Spontaneous Rosette Formation with Erythrocytes F. Aubrit, B. Raynal, A. Bernard and L. Boumsell Requires Authentication Unlicensed Licensed	521
A Dual Function of the T4 Molecule in the Cytolytic Activity of Human T Cell Clones D. Blanchard, J. E. De Vries and H. Spits Requires Authentication Unlicensed Licensed	525
Role of Antigen-Specific T Cell Receptor and Associated Proteins in the Activation of a Cytolytic T Cell Clone Analysed by Protein Phosphorylation and by T Cell Receptor Negative Variants C. Boyer, P. Kaldy, A. Guimezanes, C. Langlet, M. Buferne and A. M. Schmitt-Verhulst Requires Authentication Unlicensed Licensed	529
Y-Chain T Cell Receptors on Denoritic Epidermal Cells J. E. Coligan, F. Koning, A. M. Lew, W. L. Maloy, W. M. Yokoyama, G. Stingl and E. M. Shevach Requires Authentication Unlicensed Licensed	533
Stimulation of T Cells via LY-6C: A Phssphatidylinositol-Anchored Cell Surface Molecule which Generates Intracellular Calcium Mobilization upon Cross-Linking F. J. Dumont, R. R. Palfree and R. C. Boltz Requires Authentication Unlicensed Licensed	537
New Subgroups in the Human T Cell Rearranging VΓ Gene Locus A. Forster, S. Huch, N. Ghanem, M. P. Lefranc and T. H. Rabbits Requires Authentication Unlicensed Licensed	541
Genomic Organisation of the Constant Regions of the Human T-Cell Rearranging Gene Γ M. P. Lefranc, A. Forster and T. H. Rabbits Requires Authentication Unlicensed Licensed	545
Second Signals for T Cell Mitogenesis Provided by a MAbs CD45 (T200) and CD5 (T1) J. Martorell, R. Vilella, L. Borche, I. Rojo and J. Vives Requires Authentication Unlicensed Licensed	549
WORKSHOP H. DIFFERENTIATION AND ACTIVATION OF B LYMPHOCYTES
Immunobiology of B Lymphocytes A. Coutinho Requires Authentication Unlicensed Licensed	553
Regulation of B Lymphocyte Responsiveness by Multiple Cytokines D. F. Jelinek and P. E. Lipsky Requires Authentication Unlicensed Licensed	557
Influence of IL4 on the Induction of Immunoglobulin Secretion by BCAF-Containing Supernatant O. Abehsira-Amar, D. L. Jankovic, M. Körner and J. Theze Requires Authentication Unlicensed Licensed	565
Early B Cells Immortalized by Epstein-Barr Virus (EBV) - A Phenotypic Study C. D. Gregory, C. Kirschgens, L. S. Young, M. Rowe, A. B. Rickinson, A. Forster and T. Rabbits Requires Authentication Unlicensed Licensed	569
The Human B Cell Repertoire: Multispecificity as a Major Characteristic of Antibodies Secreted by Human EBV-Transformable Cord Blood B Cells T. Logtenberg, A. Kroon, F. Gmelig-Meyling and R. E. Ballieux Requires Authentication Unlicensed Licensed	573
Analysis of Excessive B Cell Growth in Lymph Nodes of L. major Infected Mice: The Effect of L. major Specific T-Cell Clones M. Lohoff and M. Röllinghoff Requires Authentication Unlicensed Licensed	577
Antibody Response in vitro of Human Peripheral Blood Lymphocytes: Application of a Limiting Dilution Method A. L. Luzzati, E. Giacomini and P. Frugoni Requires Authentication Unlicensed Licensed	581
Frequency Analysis of Functional Immunoglobulin C_E Gene Expression in LPS-Reactive Murine B Cells H. F. J. Savelkoul, P. C. L. M. Linssen, J. Termeulen, A. A. Van der Linde-Preesman and R. Benner Requires Authentication Unlicensed Licensed	585
Changes in Gene Expression in Differentiating B Lymphocytes S. Sharma, L. B. King and R. B. Corley Requires Authentication Unlicensed Licensed	591
Regulation of Lipopolysaccharide (LPS)-Induced B Cell Differentiation by Ly-5 and Uyb-2 Molecules H. Yakura, G. Tate, H. Sakata, I. Kawabata, T. Ashida and M. Katagiri Requires Authentication Unlicensed Licensed	595
WORKSHOP I. LIPIDIC MEDIATORS OF THE IMMUNE RESPONSE
Phospholipid-Derived Mediators and the Immune Response Y. Thomas, J. Benveniste and J. S. Goodwin Requires Authentication Unlicensed Licensed	599
Anti-Oxidants and IL2 Synthesis J. Dornand, M. Gerber, C. Sekkat and J. C. Mani Requires Authentication Unlicensed Licensed	609
Role of Lipoxygenase Pathway Products in IL2 Synthesis M. Gerber, B. Longhi, F. Michel and A. Crastes De Paulet Requires Authentication Unlicensed Licensed	615
Platelet Activating Factor (PAF) Induces Human Suppressor Cell Activity M. Rola-Pleszczynski, C. Pouliot, L. Bouvrette, B. Pignol and P. Braquet Requires Authentication Unlicensed Licensed	621
PAF-Acether Induces an Enhanced Release of Interleukin-1 (IL-1) from Human Monocytes P. Salem, S. Deryckx, J. Benveniste and Y. Thomas Requires Authentication Unlicensed Licensed	625
Down-Regulation of CD2 and CD3 Antigen Expression by PAF-Acether E. Vivier, A. Dulioust, J. Benveniste and Y. Thomas Requires Authentication Unlicensed Licensed	629
WORKSHOP J. NEURAL MODULATION OF IMMUNITY
Neuroendocrine Modulation of Immunity H. Besedovsky and A. Del Rey Requires Authentication Unlicensed Licensed	633
Cyclic AMP Response to Dopamine in the Human Monocyte-Like Cell Line U-937 E. Kouassi, Y. S. Li, R. Rouet and J. P. Revillard Requires Authentication Unlicensed Licensed	645
ß-Endorphin Inhibits Thy-1 Antigen Expression on Murine Thymocytes and Antagonizes Thymosin Fraction V Action M. Rouabhia and P. A. Deschaux Requires Authentication Unlicensed Licensed	649
WORKSHOP K. BIOCHEMISTRY OF LEUCOCYTE STIMULATION AND EFFECTOR MECHANISMS
Genes Preferentially Expressed in Cytolytic T Cells P. Golstein, J. F. Brunet, K. Harper and F. Denizot Requires Authentication Unlicensed Licensed	653
Signal Transduction in Lymphocyte Activation K. Resch and M. Szamel Requires Authentication Unlicensed Licensed	659
IL-2 Mediated Induction of Lytic Granules, Perforin, and BLT-Esterase in Potent, Granule-Free Cytolytic T Lymphocytes Indicates an Alternative Function of Lytic Granules G. Berke and D. Rosen Requires Authentication Unlicensed Licensed	669
Extracel1ular ATP Initiates the Proliferative Response of PMA-Activated Medullary Thymocytes by Increasing their Cytosolic Free Calcium Concentration J. Dornand, C. El Moatassim and J. C. Mani Requires Authentication Unlicensed Licensed	673
Evidence for a Kinase Cascade Stimulated by Interleukin 2 in Cytotoxic T Cell Clones W. L. Farrar and S. W. Evans Requires Authentication Unlicensed Licensed	679
The Regulation of Cytoskeletal Protein Gene Expression in Lymphocytes E. McCairns, D. Fahey, R. Tayler, D. Sauer and P. B. Rowe Requires Authentication Unlicensed Licensed	683
Protein Phosphorylation During T Cell Activation J. F. Peyron and M. Fehlmann Requires Authentication Unlicensed Licensed	687
Clues to Mechanisms of Activation for Killing from the Observations of Changes in Intracellular (Ca⁺⁺) in Individual Cytolytic T Cells and Targets A. M. Schmitt-Verhulst, M. Poenie and R. Y. Tsien Requires Authentication Unlicensed Licensed	691
Induction of Activation Signals in Human T Lymphocytes M. Szamel, B. Krebs, M. Kracht and K. Resch Requires Authentication Unlicensed Licensed	697
Both Lyt2⁺ and L3T4⁺ Cell Subsets Secrete the Serine Esterase Granzyme A in Response to a Specific Antigenic Stimulus F. Velotti, M. Nabholz and H. R. MacDonald Requires Authentication Unlicensed Licensed	701
WORKSHOP L. ACCESSORY CELLS-LYMPHOCYTE INTERACTIONS
Accessory Cells-Lymphocyte Interactions R. L. O’Brien and A. Novogrodsky Requires Authentication Unlicensed Licensed	705
A Role for HLA-Class I Molecules from Accessory Cells in T-Cell Activation S. Huet, B. Raynal, A. Bernard, L. Degos, J. Dausset and L. Boumsell Requires Authentication Unlicensed Licensed	709
Adhesion Molecules of Monocytes M. Patarroyo, J. Prieto, P. G. Beatty, E. A. Clark and C. G. Gahmberg Requires Authentication Unlicensed Licensed	713
Cellular and Molecular Basis of Self-Induced Proliferation of T Lymphocytes (SIPofT) B. M. Sahai and J. G. Kaplan Requires Authentication Unlicensed Licensed	717
Human T Cell Activation: Participation of T Cell Differentiation Antigen Cluster 2 (CD2) in the Generation and/or Transduction of Accessory Cell Signals M. Suthanthiran, J. Hill, V. K. Murthi, R. Schwartz, A. Subramaniam, A. Novogrodsky and K. H. Stenzel Requires Authentication Unlicensed Licensed	723
WORKSHOP PI. IDIOTYPIC REGULATION
The Influence of Vk Gene Polymorphism on the Induction of Silent Idiotypes in the Arsonate System M. Brait, J. Marvel, J. Tassignon, J. D. Capra and J. Urbain Requires Authentication Unlicensed Licensed	727
Allogeneic Manipulation of the "GAT" Idiotypic Cascade does not Influence the VH Gene Usage S. Corbet, M. Hirn, C. Schiff, M. Fougereau and C. Roth Requires Authentication Unlicensed Licensed	731
Specific Suppression of the Primary Antibody Response with Immune Complexes Formed in Antibody Excess Depends on the Idiotype and the Isotype of the Antibody Forming the Complex M. J. Caulfield Requires Authentication Unlicensed Licensed	739
The HLA-Restricted Presentation of Idiotype to Human Anti-Idiotypic T Cell Clones does not Require Processing by Antigen Presenting Cells I . Claassen, G. Ten Hoor, H. Bunschoten, A. Osterhaus and F. Uytdehaag Requires Authentication Unlicensed Licensed	743
Idiotypic Predominance Alteration in Anti-Arsonate Response by Priming with Anti-Idiotypic Antibodies A. Gaya, E. Alsinet, M. Freixas and J. Vives Requires Authentication Unlicensed Licensed	749
Anti-Idiotype Induction of Humoral Immunity in Cattle R. A. Goldsby and A. Arulanandan Requires Authentication Unlicensed Licensed	753
Anti MHC-Receptor Cytotoxic T Lymphocytes: Their Role in the Specific Resistance to Graft-Versus-Host Reaction K. Kosmatopoulos, D. Scott-Agara, O. Halle-Pannenko and S. Orbach-Arbouys Requires Authentication Unlicensed Licensed	757
Altered Anti-Idiotype Response to a(1-3)Dextran-Associated Idiotypes in Mice Bearing an X-Linked Immune Defect H. C. Seiinka and R. Bösing-Schneider Requires Authentication Unlicensed Licensed	761
WORKSHOP N. COMPLEMENT RECEPTORS
Human CD3 Complement Receptors M. D. Kazatchkine and M. P. Dierich Requires Authentication Unlicensed Licensed	765
Influence of Antigen-Bound Complement Components C3b and C4b in Activation of Human T-Cell Clones J. Arvieux and M. G. Colomb Requires Authentication Unlicensed Licensed	781
Human C3 and C3dg Stimulate Proliferation of a Pre-B Lymphoblastoid Cell Line via CR2 Complement Receptor A. Hatzfeld, E. Fischer, J. P. Levesque, J. Hatzfeld and M. D. Kazatchkine Requires Authentication Unlicensed Licensed	785
Activation of B Lymphocytes by Zymosan-Bound C3 Fragments C. Kai, R. Szigeti, P. Aman and E. Klein Requires Authentication Unlicensed Licensed	789
Contribution of C3 Fragments to Lymphocyte Mediated Lysis of CR2 Carrying Cells E. Klein, O. Ramos, G. Sarmay, C. Kai, E. Yefenov and J. Gergely Requires Authentication Unlicensed Licensed	793
"In vivo" and "in vitro" Modulation of CR1 (C3b Receptor) Expression by its Ligand C3b F. Porteu, A. Mir and L. Halbwachs-Mecarelli Requires Authentication Unlicensed Licensed	797
WORKSHOP O. MAJOR HISTOCOMPATIBILITY COMPLEX
MHC in Leucocyte Biology D. Charron Requires Authentication Unlicensed Licensed	801
HLA Class I α1, α2, and ß2-Microglobulin Domain Interactions B. Kahn-Perles, A. Gillet, R. Hakem, B. R. Jordan, C. Layet, B. Perarnau, P. Pontarotti, J. Sire, R. Sodoyer, A. Toubert and F. A. Lemonnier Requires Authentication Unlicensed Licensed	805
Diversity and Function of Human Class II MHC Antigens E. O. Long, S. Rosen-Bronson, S. Jacobson, H. F. McFarland and R. P. Sekaly Requires Authentication Unlicensed Licensed	809
DRα-DQß Mismatched Isotype Pairing Occurs in EBV Transformed B Cell Lines V. Lotteau, L. Teyton, D. Burroughs and D. Charron Requires Authentication Unlicensed Licensed	813
Distinct Epitopes for K^d-Restricted Cytolytic T Cells Specific for HLA-CW3 or HLA-A24 Map to the same Region of HLA J. L. Maryanski, P. Pala, J. C. Cerottini, G. Corradin, B. Jordan, T. Strachan and R. Sodoyer Requires Authentication Unlicensed Licensed	819
Resistance or Susceptibility of Human Target Cells to NK Lysis: Correlation with the Surface Expression of HLA Class I Molecules and Induction of Susceptibility by Monoclonal Anti Class I Antibodies A. Quillet, A. Harel-Bellan, C. Marchiol and D. Fradelizi Requires Authentication Unlicensed Licensed	823
WORKSHOP P (SANOFI). CLINICAL APPLICATIONS OF ANTILEUCOCYTE MONOCLONAL ANTIBODIES
Anti-Leucocyte Monoclonal Antibodies: From Laboratory Reagents to Therapeutic Agents P. Poncelet Requires Authentication Unlicensed Licensed	827
Treatment of Donor Bone Marrow with FabT101 Ricin A-Chain Immunotoxin for the Prevention of Graft-versus-Host Disease after Allogeneic Bone Marrow Transplantation H. E. Blythman, G. Laurent, J. M. Derocq, E. Gluckman, D. Maraninchi, J. P. Vernant, B. Rio, M. Michallet, J. Reiffers, M. Boasson, F. Dreyfus, P. Schneider and F. K. Jansen Requires Authentication Unlicensed Licensed	831
Monoclonal Antibodies for Bone Marrow Purging before Transplantation: A Brief Review D. Campana, G. Janossy, E. Coustan-Smith, C. Bouloux, P. Poncelet and L. Foroni Requires Authentication Unlicensed Licensed	835
Comparative Efficiency of an Immunomagnetic Purging Procedure and a Rabbit Complement Lysis to Eliminate BL Cells from the Bone Marrow V. Combaret, M. C. Favrot, I. Philip and P. Poncelet Requires Authentication Unlicensed Licensed	845
In vivo Antigenic Modulation of CD5⁺ Cells in Renal Transplanted Patients Receiving Anti-CD5 Antibody Infusions G. Cordier, J. P. Revillard, J. Brochier, M. Blanc, J. Traeger, E. Carosella, M. Latour and J. Armand Requires Authentication Unlicensed Licensed	849
In vivo Therapy by CD8 Monoclonal Antibody for Delays to Hematological Recovery after Autologous Bone Marrow Transplantation M. Favrot, T. Philip, P. Biron, V. Combaret, J. M. Zucker and A. Bernard Requires Authentication Unlicensed Licensed	855
Autologous Bone Marrow Transplantation for Acute Lymphoblastic Leukemia in Remission. In vitro Purging of Inoculum with Monoclonal Antibodies and Complement P. Herve, E. Racadot, E. Plouvier, M. Flesch, J. Y. Cahn and A. Noir Requires Authentication Unlicensed Licensed	859
Immunosuppression by Murine Monoclonal Antibodies: The Rhesus Monkey Used for Preclinical Testing M. Jonker Requires Authentication Unlicensed Licensed	865
Therapeutic Applications of Monoclonal Antibodies for Lymphoma and Leukemia M. S. Kaminski and K. A. Foon Requires Authentication Unlicensed Licensed	871
BMA 031 - The TCR Specific Monoclonal Antibody for Clinical Applications R. Kurrle, R. Zerban, F. R. Seiler, B. Nashan and K. Wonigeit Requires Authentication Unlicensed Licensed	885
Immunoassays for the Monitoring of Kidney Graft's Transplanted Patients under 33B3.1 MOAB Therapy B. Le Mauff, F. Boeffard, J. P. Soulillou and Y. Jacques Requires Authentication Unlicensed Licensed	891
Prospective Randomized Studies of T Cell Depletion in HLA Matched Bone Marrow Transplantation (BMT) for Leukemia: 2 Studies of the GEGMO in 92 Patients D. Maraninchi, E. Gluckman, D. Guyotat, B. Rio, D. Blaise, J. L. Pico, V. Leblond, M. Michallet, G. Laurent, M. H. Gaspard, F. Dreyfus, N. Ifrah, J. Reiffers, A. Bordigoni, A. Bernard, M. Delage and F. Jansen Requires Authentication Unlicensed Licensed	895
A Monoclonal Anti Interleukin 2 Receptor Prevents Human Kidney Graft Rejection J. P. Soulillou, B. Le Mauff, Y. Jacques, P. Peyronnet, M. Hourmant, D. Cantarovich, P. Dubigeon, D. Olive, C. Mawas, M. Delage and M. Hirn Requires Authentication Unlicensed Licensed	901
Clinical Pharmacology of 0KT3 L. Chatenoud and J. F. Bach Requires Authentication Unlicensed Licensed	905
Introduction to the Clinical Use of Monoclonal Antibodies as Immunosuppressive Agents C. Mawas Requires Authentication Unlicensed Licensed	915
General Considerations on the Quality Control of Monoclonal Antibodies before Therapeutic Use in Man R. Thorpe and G. C. Schild Requires Authentication Unlicensed Licensed	927
Immunotoxins with Therapeutic Use in Man F. K. Jansen, H. E. Blythman, C. Bouloux, B. Bourrie, P. Carayon, P. Casellas, J. M. Derocq, D. Dussossoy, O. Gros, P. Gros, G. Laurent, J. C. Laurent, G. Richer, P. Schneider, P. Vandest, H. Vidal and G. A. Voisin Requires Authentication Unlicensed Licensed	935
AUTHOR INDEX Requires Authentication Unlicensed Licensed	943
SUBJECT INDEX Requires Authentication Unlicensed Licensed	949
Backmatter Requires Authentication Unlicensed Licensed	962

Publishing information

Pages and Images/Illustrations in book

eBook published on:

July 8, 2019

eBook ISBN:

9783110850253

Hardcover published on:

March 1, 1988

Hardcover ISBN:

9783110107609

Edition:

Reprint 2019

Pages and Images/Illustrations in book

Front matter:

21

Main content:

960

Other:

Num. figs.

https://doi.org/10.1515/9783110850253

eBook ISBN: 9783110850253

Hardcover ISBN: 9783110107609

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Lymphocyte Activation and Differentiation

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