Electrochemistry of 6,7-Dioxo-Pteridines

Kapitel in diesem Buch

1. Frontmatter I
2. Preface V
3. Contents VII
4. List of Contributors XIII
5. Significant Steps in the Discovery and Application of Pteridines 1
6. Specific Inhibition of Dihydrofolate Biosynthesis - A New Approach to Chemotherapy 27
7. Mammalian Dihydrofolate Reductase: Porcine Liver Enzyme 51
8. Kinetic Studies of Escherichia Coli Dihydropteroate Synthetase 61
9. Dihydropteroate Synthase: Purification by Affinity Chromatography and Mechanism of Action 73
10. The Properties of Gamma Glutamyl Hydrolase (Conjugase) from Bovine Liver 85
11. The Purification of Riboflavin Synthetase by Affinity Chromatography Using 7-Oxolumazines 93
12. Interaction of Riboflavin Synthetase with Analogues of 6,7-Dimethyl-8-Ribityllumazine 101
13. Structure-Activity Relationship Among Pteridine Derivatives and Related Quinazolines as Inhibitors of Dihydrofolate Reductases 125
14. Spectral Studies of Thymidylate Synthetase 133
15. Four Folate Metabolizing Enzymes of Mouse Embryo Fibroblasts and L-Cells as Tested During the Culture Cycle 143
16. The Activity of the Cobalamine-dependent Methionine- Synthetase (5-Methyl-5, 6, 7, 8-Tetrahydrofolic Acid: Homocysteine Methyltransferase) in Rapidly Growing Human Cells and the Effect of Some Folic Acid Derivatives and Analogues 153
17. The Role of Folate Binding Proteins in Folate Metabolism 165
18. Transport of Folate Compounds into Mammalian and Bacterial Cells 179
19. Transport of Folate Compounds through the Membrane of Human Lymphoblastoid Cells 197
20. The Characterization of High Molecular Weight Complexes of Folic Acid in Mammalian Tissues 209
21. The Enzymic Synthesis of Pterins in Escherichia Coli 219
22. Biosynthesis of Pterins in Mammalian Systems 247
23. The Synthesis of Pterins Catalyzed by Enzymes from Drosophila melanogaster 265
24. Biosynthesis of Biopterin in the Intact Rat and in Mouse Neuroblastoma Cells 273
25. Studies on the Biosynthesis of Riboflavin 285
26. Studies on the Mechanism of Phenylalanine Hydroxylase: Detection of an Intermediate 291
27. Effect of Pteridine Cofactor Structure on the Regulation of Phenylalanine Hydroxylase Activity 305
28. Interrelationships between C-1 Metabolism and Photosynthesis in Euglena Gracilis 321
29. Folate Derivatives and Patterns of C-1 Metabolism in Neurospora Crassa, Wild Type, Ser-1 and Formate Mutants 331
30. The Biosynthesis of Folic Acid and Pteridine Cofactor (s) and its Regulation 341
31. Reduced Pterins as Possible Mediators in Cellular Electron Transfer 359
32. The Handling and Metabolism of Folates in the Rat and Man, with Especial Relationship to Disease 373
33. Red Blood Cell Polyglutamyl Folates in Vitamin B12 Deficiency 407
34. Novel Urinary Metabolites of Folic Acid in the Rat 413
35. "Prune"/"Killer-of-Prune": A Complementary Lethal System in Drosophila Melanogaster Affecting Pteridine Metabolism 429
36. Kynurenine as Trigger in Pterorhodin Synthesis in Ephestia Kuhniella Z. 437
37. Growth Stimulation by 6-Phenacylisoxanthopterin and Related Compounds 445
38. The Possible Role in Gene Regulation of an Isoxanthopterinbinding Protein from Oncopeltus Embryos 453
39. Poly-γ-Glutamyl Chain Lengths in some Natural Folates and Contributions of Folic Acid Synthesized by Intestinal Microflora to Rat Nutrition 465
40. Tissue-Specific Synthesis of Methotrexate Polyglutamates in the Rat 475
41. A Convenient Synthesis of Methotrexate and Related Compounds 485
42. Methods for the Synthesis of Folic Acid Analogs, Substituted Folic Acid Analogs, Folic Acid and Folic Acid Conjugates 495
43. New Folate Analogs: Alterations in the C⁹-N¹⁰ Region 503
44. The Synthesis and Study of 10-Thia-10-Deaza-Analogs of Pteroic Acid, Folic Acid, and of Related Compounds: The Problem of Racemization in the Cyclization of Substituted 2-Amino-3-Cyanopyrazines 515
45. Synthesis and Properties of 5-Methyldihydrofolate 525
46. A Coloured Oxidation Product from Tetrahydrofolate 535
47. Pteridine Synthesis 543
48. The 7-Azapteridines 575
49. Enzymatic Oxidation of Pteridin-4-ones and Related Compounds 603
50. Synthesis and Structure of Dihydro- and Tetrahydroderivatives of Pterin 6,7-Dicarboxylic Acid 617
51. Direct Conversion of 4-Hydroxypteridines to their 4-Amino Analogs 627
52. High Pressure Liquid Chromatography of Substituted Pteridines and Tetrahydropteridines 633
53. Electrochemistry of Pteridines 645
54. Pteridone Mediators in the Electrolysis of Biological Macromolecules 671
55. Electrochemistry of 6,7-Dioxo-Pteridines 681
56. Protonation and Covalent Hydration of Nitrogen Heterocycles - A Carbon-13 NMR Study [1] 687
57. Reindarstellung und NMR-Spektroskopische Untersuchung von 5, 6, 7, 8-Tetrahydrofolsäure 695
58. Sterische Wechselwirkungen in Substituierten Tetrahydropterinen 705
59. Kinetisch-Mechanistische Untersuchungen an 5-Formyl-6, 7-Dimethyl-5, 6, 7, 8-Tetrahydropterin, 10-Formyl-Folsäure, 5,10-Methenyl-5, 6, 7, 8-Tetrahydrofolsäure und 5-Methyl-10-Formyl-5, 6, 7, 8- Tetrahydrofolsäure 711
60. CNDO-Rechnungen an Pterin, 6, 7-Dimethyl-7, 8- Dihydropterin und 5-Formyl-6, 7-Dimethyl-5, 6, 7, 8- Tetrahydropterin [1] 721
61. H-D Exchange in Pteridin-4-ones 725
62. Oxidation-Reduction Properties of Pterins 731
63. Autoxidative Conversions of Tetrahydropteridines and some Related Ringsystems 753
64. Autoxidation of Tetrahydropterins 775
65. Synthesis of Thiolumazine Nucleosides 783
66. Pteridine Nucleotides, Synthesis and Enzymic Studies 795
67. Biology of Pigmentation in Pieridae Butterflies 805
68. The Pterins of the Pieridae and their Biosynthesis: Metabolism of D-Erythro-Neopterin and its 7, 8- Dihydro Derivative in Colias Croceus 841
69. Occurrence and Distribution of Known Pterins in Some Species of Diptera 851
70. Pteridines in the Mammalian Retina and Light Effects 861
71. Les Pterines des Planctons Marins: Identification de plusieurs Dérivés chez les Algues Unicellulaires. Sur la Distribution des Pterines chez la Crustacés Copepodes 871
72. Russupteridine 881
73. Aurodrosopterins in Eye Colour Mutants of Drosophila Melanogaster 919
74. New Results about Drosopterins 931
75. Synthesis and Absolute Configuration of Sepiapterin 941
76. Backmatter 950