Protein-Ligand Interactions: Proceedings of the Symposium held at the University of Konstanz, Germany, September 1974

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Protein-Ligand Interactions

Proceedings of the Symposium held at the University of Konstanz, Germany, September 1974

Edited by: Horst Sund and Gideon Blauer

Language: German

Published/Copyright: 1975

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Life Sciences Biochemistry

Frontmatter Publicly Available Download PDF	I
Preface Publicly Available Download PDF	V
Section I. General
Letter from J. Wyman to the Members of the Symposium A. Colosimo, M. Brunori and J. Wyman Requires Authentication Unlicensed Licensed	1
Concerted Changes in an Allosteric Macromolecule Alfredo Colosimo, Maurizio Brunori and Jeffries Wyman Requires Authentication Unlicensed Licensed	3
Ligand Interactions in Globular Proteins Gregorio Weber Requires Authentication Unlicensed Licensed	15
Discussion Requires Authentication Unlicensed Licensed	25
Ligand Binding to Enzyme Complexes Kasper Kirschner, Wolfgang Weischet and Robert L. Wiskocil Requires Authentication Unlicensed Licensed	27
Discussion Requires Authentication Unlicensed Licensed	41
Properties of Polymeric Proteins Bound to Solid Matrices: Subunit Exchange Chromatography Eraldo Antonini, M. Rosaria Rossi Fanelli and Emilia Chiancone Requires Authentication Unlicensed Licensed	45
Discussion Requires Authentication Unlicensed Licensed	57
Contributions of Aromatic Amino Acid Residues to the Optical Activity of Protein-Ligand Complexes Robert W. Woody Requires Authentication Unlicensed Licensed	60
Discussion Requires Authentication Unlicensed Licensed	74
Section II. Enzymes
The Architecture of the Coenzyme Binding Domain in Dehydrogenases as Revealed by X-Ray Structure Analysis Manfred Buehner Requires Authentication Unlicensed Licensed	80
Discussion Requires Authentication Unlicensed Licensed	95
The Interaction of Glutamate Dehydrogenase with a Coenzyme Analog R. Koberstein, H. Dieter and H. Sund Requires Authentication Unlicensed Licensed	99
Discussion Requires Authentication Unlicensed Licensed	109
The Interaction of Adenosine Triphosphate and its Analogs with Myosin and the Modification by Actin R. S. Goody and H. G. Mannherz Requires Authentication Unlicensed Licensed	111
Discussion Requires Authentication Unlicensed Licensed	128
Isolation of a Guanylnucleotide Binding Protein from Pigeon Erythrocyte Membranes Thomas Pfeuffer and Ernst J. M. Helmreich Requires Authentication Unlicensed Licensed	130
Discussion Requires Authentication Unlicensed Licensed	142
On the Binding of Isoleucine and Related Amino Acids to Isoleucyl-tRNA Synthetase from Escherichia Coli MRE 600 J. Flossdorf, H.-J. Prätorius and M.-R. Kula Requires Authentication Unlicensed Licensed	145
Discussion Requires Authentication Unlicensed Licensed	151
The Effect of Small Molecules on the Affinity of Individual Chains in Hemoglobin and on its Cooperativity K. H. Winterhalter, A. Mansouri and E. E. Di lorio Requires Authentication Unlicensed Licensed	153
Discussion Requires Authentication Unlicensed Licensed	165
Cooperative Interactions without Symmetry or Subunits Jacinto Steinhardt Requires Authentication Unlicensed Licensed	167
Discussion Requires Authentication Unlicensed Licensed	174
A Nuclear Magnetic Resonance Study of Activator Binding by Carboxypeptidase A Tamar Kushnir and Gil Navon Requires Authentication Unlicensed Licensed	176
Discussion Requires Authentication Unlicensed Licensed	193
Section III. Repressors
Lactose Operator Sequences and the Action of Lac Repressor Walter Gilbert, Jay Gralla, John Majors and Allan Maxam Requires Authentication Unlicensed Licensed	197
Discussion Requires Authentication Unlicensed Licensed	211
The Active Sites of Lac Repressor B. Müller Hill, T. Fanning, N. Geisler, D. Gho, J. Kania, P. Kathmann, H. Meissner, M. Schlotmann, A. Schmitz, I. Triesch and K. Beyreuther Requires Authentication Unlicensed Licensed	215
Discussion Requires Authentication Unlicensed Licensed	229
Lac Repressor K. Weber, J. G. Files, T. Piatt, D. Ganem and J. H. Miller Requires Authentication Unlicensed Licensed	232
Discussion Requires Authentication Unlicensed Licensed	239
The Use of Suppressed Nonsense Mutations to Generate Altered Lac Repressor Molecules J. H. Miller, C. Coulondre, U. Schmeissner, A. Schmitz and P. Lu Requires Authentication Unlicensed Licensed	242
Discussion Requires Authentication Unlicensed Licensed	256
Effect of Alterations in Lac Operator DNA on Repressor Binding Suzanne Bourgeois, Mary D. Barkley, Alan Jobe, John R. Sadler and James C. Wang Requires Authentication Unlicensed Licensed	257
Discussion Requires Authentication Unlicensed Licensed	271
Interaction of Lac Repressor with Non-Specific DNA Binding Sites Peter H. von Hippel, Arnold Revzin, Carol A. Gross and Amy C. Wang Requires Authentication Unlicensed Licensed	274
Discussion Requires Authentication Unlicensed Licensed	289
Section IV. Receptors
Binding and Functional States of the Cholinergic Receptor Protein from Torpedo Marmorata H. Sugiyama, J.L. Popot, J.B. Cohen, M. Weber and J.P. Changeux Requires Authentication Unlicensed Licensed	295
Discussion Requires Authentication Unlicensed Licensed	308
Subunit Structure and Binding Sites of the Acetylcholine Receptor F. Hucho, A. Gordon and H. Sund Requires Authentication Unlicensed Licensed	312
Discussion Requires Authentication Unlicensed Licensed	320
Further Characterization of Purified Acetylcholine Receptor and its Incorporation into Phospholipid Vesicles Mark G. McNamee, Cheryl L. Weill and Arthur Karlin Requires Authentication Unlicensed Licensed	322
Discussion Requires Authentication Unlicensed Licensed	333
Structural and Functional Studies of an Acetylcholine Receptor M.A. Raftery, J. Bode, R. Vandlen, D. Michaelson, J. Deutsch, T. Moody, M.J. Ross and R.M. Stroud Requires Authentication Unlicensed Licensed	334
Discussion Requires Authentication Unlicensed Licensed	358
Section V. Antibodies, Drugs and Metabolites
Antibody Combining Sites as a Model for Molecular Recognition I. Pecht Requires Authentication Unlicensed Licensed	364
Discussion Requires Authentication Unlicensed Licensed	377
Antibiotic Action on Enzymes Involved in Peptidoglycan Synthesis Harold R. Perkins, Jean-Marie Ghuysen, Jean-Marie Frère and Manuel Nieto Requires Authentication Unlicensed Licensed	380
Discussion Requires Authentication Unlicensed Licensed	391
Problems in Studying Protein Binding with Regard to the Interaction of Steroids with a Specific Binding Globulin R.A Lutz, U.-W. Wiegand and H. G. Weder Requires Authentication Unlicensed Licensed	393
Discussion Requires Authentication Unlicensed Licensed	404
The Interaction of Low-Molecular Compounds with Serum Albumin as Measured by Optical Methods. Circular Dichroism of Bilirubin-Human Serum Albumin Complexes in the Presence of Alcohols in Aqueous Solution G. Blauer and E. Lavie Requires Authentication Unlicensed Licensed	407
Discussion Requires Authentication Unlicensed Licensed	417
Section VI. Detergents and Electrolytes
The Nature of Specific and Non-Specific Interactions of Detergents with Proteins: Complexing and Unfolding Jacinto Steinhardt Requires Authentication Unlicensed Licensed	422
Discussion Requires Authentication Unlicensed Licensed	434
Interaction of Detergents with Proteins: Effect of Counter Ions on the System Ferrimyoglobin- Laurylpyridinium Halides in Aqueous Medium J. Yonath and G. Blauer Requires Authentication Unlicensed Licensed	437
Discussion Requires Authentication Unlicensed Licensed	449
Influence of Ions on the Kinetics of Cooperative Conformational Changes in Globular Proteins Fritz M. Pohl Requires Authentication Unlicensed Licensed	451
Discussion Requires Authentication Unlicensed Licensed	460
Neutral Salt Effects on the Conformational Stability of Biological Macromolecules Peter H. von Hippel Requires Authentication Unlicensed Licensed	462
Discussion Requires Authentication Unlicensed Licensed	479
Concluding Remarks Peter H. von Hippel Requires Authentication Unlicensed Licensed	482
Index of Contributors Requires Authentication Unlicensed Licensed	485
Subject Index Requires Authentication Unlicensed Licensed	488
Backmatter Requires Authentication Unlicensed Licensed	497

Publishing information

Pages and Images/Illustrations in book

eBook published on:

March 18, 2019

eBook ISBN:

9783110830811

Hardcover published on:

March 1, 1975

Hardcover ISBN:

9783110048810

Edition:

Reprint 2019

Pages and Images/Illustrations in book

Front matter:

16

Main content:

486

Other:

Num. figs.

https://doi.org/10.1515/9783110830811

eBook ISBN: 9783110830811

Hardcover ISBN: 9783110048810

Keywords for this book

Proteins -- Congresses; Ligands (Biochemistry) -- Congresses

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Protein-Ligand Interactions

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