Contents

Chapters in this book

1. I-IV I
2. Contents V
3. Introductory Remarks VII
4. Biological Effects of Dehydroepiandrosterone: A Review 1
5. Possible "Anti-Aging" Effects of Caloric Restrictions as Indicated by Dehydroepiandrosterone Sulfate Levels 31
6. DHEA Cytokine Dysregulation in Aging and AIDS 41
7. Dehydroepiandrosterone (DHEA) and its Role in the Aging Immune System 57
8. Restoration of Immunocompetence in Aging and Other Inflammatory Disease States by Dehydroepiandrosterone-3ß-Sulfate, an Activator of the Peroxisome Proliferator-Activated Receptor Alpha (PPARα) 65
9. The Antiobesity Effect of Dehydroepiandrosterone (DHEA): Clinical Studies in the Canine Model 119
10. DHEA(S) and Obesity: Potential Antiadipogenic Mechanisms of Action 131
11. The Antiobesity Effect of Dehydroepiandrosterone Treatment 157
12. Dehydroepiandrosterone and Obesity 173
13. DHEA, Obesity and Cardiovascular Disease 191
14. Role of Dehydroepiandrosterone in Experimental and Human Carcinogenesis 215
15. Hepatocarcinogenesis by Dehydroepiandosterone. I. Induction of Neoplasms and Sequential Cellular Changes During Neoplastic Development 237
16. Hepatocarcinogenesis by Dehydroepiandrosterone. II. Biochemical and Molecular Changes During Neoplastic Development 251
17. Constraints on the DHEAS-lnduced Enhancement of Hippocampal Function: Non-Linear Dose-Response Functions and DHEAS-Stress Interactions 261
18. Neuropsychiatric Effects of Dehydroepiandrosterone (DHEA) 271
19. DHEA, The Precursor of Androgens and Estrogens in Peripheral Tissues in the Human: Intracrinology 299
20. Studies on the Metabolism of DHEA in Rats and Mice 343
21. Androgens and Liver Function 363
22. DHEA and Mitochondrial Respiration 377
23. Dehydroepiandrosterone Sulfate (DHEAS) Increases Osteoblastic Activities In Vitro 393
24. Dehydroepiandrosterone-Dexamethasone Interactions on Nb2 Lymphoma Cell Proliferation 407
25. Dehydroepiandrosterone (DHEA), and Its Relation to the Pathology of "Stress" Reactions 419
26. Author Index 431
27. Subject Index 432