Chapter 7 Growing impact of herbal bioenhancers in pharmaceutical industries
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Vaibhav Bhamare
Abstract
Ayurvedic expertise has made a significant contribution to drug research in the world, with new methods of identifying active compounds. In comparison to modern medicines, herbal medicines have succeeded to emphasize the world for their use, with advantageous therapeutic effects and fewer adverse effects. However, in vitro/in vivo findings for these herbal drugs or extracts are not so impressively correlative. Poor lipid solubility, improper molecular size, and prolonged therapy of phytoconstituents leads to poor absorption, followed by poor bioavailability and treatment expenses. Herbal bioenhancers are nontherapeutic active phytomolecules that, when co-administered at low doses, improve the bioavailability, bioefficacy, and biological activity of different drugs without having a synergistic impact with medication. Since herbal bioenhancers are healthy, nontoxic, inexpensive, easy to obtain, nonaddictive, pharmacologically inert, and nonallergenic, they are enticing pharmaceutical industries as a valuable and most effective means of bioavailability enhancement. Nowadays, industries are focusing on improvement in pharmacokinetic parameters of potent active pharmaceutical ingredients using various bioenhancing mechanisms that can help through alteration in enzyme activity, phytosomal formulation system, escape protein modifications, effects of cholagogic or choleretic agent, and heat production in the organism. An emphasis is made to tackle multidrug resistance in the treatment of infectious diseases. Bioenhancers significantly contribute to the drug development process, with innovative methods for identifying active compounds, using natural drugs and products. Herbal bioenhancers are becoming increasingly popular as a paradigm-shifting technology for improving the bioavailability and bioefficacy of various classes of drugs, nutraceuticals, and veterinary medicines, thanks to recent advances in drug delivery.
Abstract
Ayurvedic expertise has made a significant contribution to drug research in the world, with new methods of identifying active compounds. In comparison to modern medicines, herbal medicines have succeeded to emphasize the world for their use, with advantageous therapeutic effects and fewer adverse effects. However, in vitro/in vivo findings for these herbal drugs or extracts are not so impressively correlative. Poor lipid solubility, improper molecular size, and prolonged therapy of phytoconstituents leads to poor absorption, followed by poor bioavailability and treatment expenses. Herbal bioenhancers are nontherapeutic active phytomolecules that, when co-administered at low doses, improve the bioavailability, bioefficacy, and biological activity of different drugs without having a synergistic impact with medication. Since herbal bioenhancers are healthy, nontoxic, inexpensive, easy to obtain, nonaddictive, pharmacologically inert, and nonallergenic, they are enticing pharmaceutical industries as a valuable and most effective means of bioavailability enhancement. Nowadays, industries are focusing on improvement in pharmacokinetic parameters of potent active pharmaceutical ingredients using various bioenhancing mechanisms that can help through alteration in enzyme activity, phytosomal formulation system, escape protein modifications, effects of cholagogic or choleretic agent, and heat production in the organism. An emphasis is made to tackle multidrug resistance in the treatment of infectious diseases. Bioenhancers significantly contribute to the drug development process, with innovative methods for identifying active compounds, using natural drugs and products. Herbal bioenhancers are becoming increasingly popular as a paradigm-shifting technology for improving the bioavailability and bioefficacy of various classes of drugs, nutraceuticals, and veterinary medicines, thanks to recent advances in drug delivery.
Chapters in this book
- Frontmatter I
- Contents V
- List of contributing authors VII
- Chapter 1 Biopotentiation using herbals: novel approach for poorly bioavailable drugs 1
- Chapter 2 Herbal bioenhancers in microparticulate drug delivery 27
- Chapter 3 Herbal bioenhancers in nanoparticulate drug delivery system 45
- Chapter 4 Role of herbal bioenhancers in tuberculosis and drug delivery thereof 87
- Chapter 5 Herbal bioenhancers in cancer drug delivery 103
- Chapter 6 Pharmacotherapeutics and pharmacokinetics of herbal bioenhancers 149
- Chapter 7 Growing impact of herbal bioenhancers in pharmaceutical industries 191
- Chapter 8 Herbal bioenhancers and improvement of the bioavailability of drugs 211
- Chapter 9 Case study: Indian herbal bioenhancers 239
- Chapter 10 Current trends on herbal bioenhancers 275
- Chapter 11 Future perspectives of herbal bioenhancer 307
- Chapter 12 Herbal bioenhancers in veterinary phytomedicine 325
- Keyword index 367
Chapters in this book
- Frontmatter I
- Contents V
- List of contributing authors VII
- Chapter 1 Biopotentiation using herbals: novel approach for poorly bioavailable drugs 1
- Chapter 2 Herbal bioenhancers in microparticulate drug delivery 27
- Chapter 3 Herbal bioenhancers in nanoparticulate drug delivery system 45
- Chapter 4 Role of herbal bioenhancers in tuberculosis and drug delivery thereof 87
- Chapter 5 Herbal bioenhancers in cancer drug delivery 103
- Chapter 6 Pharmacotherapeutics and pharmacokinetics of herbal bioenhancers 149
- Chapter 7 Growing impact of herbal bioenhancers in pharmaceutical industries 191
- Chapter 8 Herbal bioenhancers and improvement of the bioavailability of drugs 211
- Chapter 9 Case study: Indian herbal bioenhancers 239
- Chapter 10 Current trends on herbal bioenhancers 275
- Chapter 11 Future perspectives of herbal bioenhancer 307
- Chapter 12 Herbal bioenhancers in veterinary phytomedicine 325
- Keyword index 367
