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7. Nanoparticles and genotoxicity

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Nanomaterials Safety
This chapter is in the book Nanomaterials Safety

Abstract

Nanotechnology has wide scale applications in industry, medicine, our day-to-day lives and commercial sectors. However, many nanoparticles (NPs) have caused chromosomal aberrations, DNA, oxidative DNA damage and mutations and mediated cytotoxicity and genotoxic effects. Recently, it has been observed that NPs cause epigenetic changes. We discuss in this chapter the effect of different NPs mediating genotoxic effects. Green synthesis of nanoparticles have been able to reduce the genotoxic effects caused by NPs. In this chapter, we discuss the different genotoxic effects of different types of NPs detected by biochemical assays. We also discuss the strategies used by scientists to overcome genotoxicity of NPs. Future research needs to focuss on designing the NPs without genotoxic properties

Abstract

Nanotechnology has wide scale applications in industry, medicine, our day-to-day lives and commercial sectors. However, many nanoparticles (NPs) have caused chromosomal aberrations, DNA, oxidative DNA damage and mutations and mediated cytotoxicity and genotoxic effects. Recently, it has been observed that NPs cause epigenetic changes. We discuss in this chapter the effect of different NPs mediating genotoxic effects. Green synthesis of nanoparticles have been able to reduce the genotoxic effects caused by NPs. In this chapter, we discuss the different genotoxic effects of different types of NPs detected by biochemical assays. We also discuss the strategies used by scientists to overcome genotoxicity of NPs. Future research needs to focuss on designing the NPs without genotoxic properties

Chapters in this book

  1. Frontmatter I
  2. Acknowledgment VII
  3. Contents IX
  4. 1. Nanomaterials safety and health hazard 1
  5. 2. Nanotoxicity and the immune system 43
  6. 3. Nanoparticles and stem cells 81
  7. 4. Nanoparticles and brain 113
  8. 5. Nanoparticles, neurotoxicity and safety in application to neurological disorders 127
  9. 6. Health effects of inhaled nanomaterials 151
  10. 7. Nanoparticles and genotoxicity 171
  11. 8. Nanoparticles and occupational health hazards 197
  12. 9. Toxicity and effect of nanoparticles on liver and kidneys, and kidney disorders 207
  13. 10. Nanomaterials and aquatic toxicity 215
  14. 11. Nanotoxicity and plants 237
  15. Glossary 247
  16. Abbreviations 265
  17. Index 273
https://doi.org/10.1515/9783110579093-007

Chapters in this book

  1. Frontmatter I
  2. Acknowledgment VII
  3. Contents IX
  4. 1. Nanomaterials safety and health hazard 1
  5. 2. Nanotoxicity and the immune system 43
  6. 3. Nanoparticles and stem cells 81
  7. 4. Nanoparticles and brain 113
  8. 5. Nanoparticles, neurotoxicity and safety in application to neurological disorders 127
  9. 6. Health effects of inhaled nanomaterials 151
  10. 7. Nanoparticles and genotoxicity 171
  11. 8. Nanoparticles and occupational health hazards 197
  12. 9. Toxicity and effect of nanoparticles on liver and kidneys, and kidney disorders 207
  13. 10. Nanomaterials and aquatic toxicity 215
  14. 11. Nanotoxicity and plants 237
  15. Glossary 247
  16. Abbreviations 265
  17. Index 273
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