10. Copper and its complexes: A pharmaceutical perspective
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Subash Chandra Sahoo
Abstract
Copper came into view mainly due to its enzymatic function in the human body and directly or indirectly plays a major role in regulating human activities like maintenance of the immune system, cancer, osteoporosis, arthritis, skin disease and heart problems etc. All the disease mentioned are also governed by copper and depend upon the amount of copper consumed in daily life. Therefore, knowing about the optimum intake of copper in the diet is very crucial for human health. Copper and its complexes also possess a good recognition in the field of medical science as bioactive agents. These copper dependent bioactive agents, due to their activity, are attracting interest from scientists for their use as prospective drugs for the treatment of several diseases. In this chapter we have tried to summarize the role of copper and its complexes with reference to toxicity level, sources, progress in the development of drugs and various important discussions about the mode of action.
Abstract
Copper came into view mainly due to its enzymatic function in the human body and directly or indirectly plays a major role in regulating human activities like maintenance of the immune system, cancer, osteoporosis, arthritis, skin disease and heart problems etc. All the disease mentioned are also governed by copper and depend upon the amount of copper consumed in daily life. Therefore, knowing about the optimum intake of copper in the diet is very crucial for human health. Copper and its complexes also possess a good recognition in the field of medical science as bioactive agents. These copper dependent bioactive agents, due to their activity, are attracting interest from scientists for their use as prospective drugs for the treatment of several diseases. In this chapter we have tried to summarize the role of copper and its complexes with reference to toxicity level, sources, progress in the development of drugs and various important discussions about the mode of action.
Chapters in this book
- Frontmatter I
- Preface V
- Table of Contents VII
- List of Contributing Authors XI
- 1. Overview of chemical drug design 1
- 2. Drug designing in novel drug discovery: Trends, scope and relevance 15
- 3. Structure- and ligand-based approaches in drug designing 31
- 4. Drug design applied to natural products against neglected diseases 53
- 5. Natural product hybrid compounds as drug leads 87
- 6. Drug metabolism 107
- 7. Mistletoe lectin: A promising cancer therapeutic 165
- 8. Antipsychotics 183
- 9. Chemometric analysis: A novel tool for herbal drug analysis and designing 199
- 10. Copper and its complexes: A pharmaceutical perspective 215
- 11. Thiazole: A privileged scaffold in drug discovery 243
- Index 283
Chapters in this book
- Frontmatter I
- Preface V
- Table of Contents VII
- List of Contributing Authors XI
- 1. Overview of chemical drug design 1
- 2. Drug designing in novel drug discovery: Trends, scope and relevance 15
- 3. Structure- and ligand-based approaches in drug designing 31
- 4. Drug design applied to natural products against neglected diseases 53
- 5. Natural product hybrid compounds as drug leads 87
- 6. Drug metabolism 107
- 7. Mistletoe lectin: A promising cancer therapeutic 165
- 8. Antipsychotics 183
- 9. Chemometric analysis: A novel tool for herbal drug analysis and designing 199
- 10. Copper and its complexes: A pharmaceutical perspective 215
- 11. Thiazole: A privileged scaffold in drug discovery 243
- Index 283
