Contents

Kapitel in diesem Buch

1. Frontmatter i
2. Preface v
3. List of contributing authors vii
4. Contents xiii
5. 1. Optical spectroscopy and calorimetry 1
6. 2. Footprinting methods for mapping RNA-protein and RNA-RNA interactions 29
7. 3. Chemical approaches to the structural investigation of RNA in solution 51
8. 4. Bioorthogonal modifications and cycloaddition reactions for RNA chemical biology 75
9. 5. Analysis of RNA conformation using comparative gel electrophoresis 101
10. 6. Virus RNA structure deduced by combining X-ray diffraction and atomic force microscopy 125
11. 7. Investigating RNA structure and folding with optical tweezers 157
12. 8. Fluorescence resonance energy transfer as a tool to investigate RNA structure and folding 181
13. 9. RNA studies by small angle X-ray scattering in solution 215
14. 10 Integrative structure-function analysis of large nucleoprotein complexes 243
15. 11 Structure and conformational dynamics of RNA determined by pulsed EPR 261
16. 12. NMR-based characterization of RNA structure and dynamics 287
17. 13. Crystallization of RNA for structure determination by X-ray crystallography 319
18. 14. RNA structure prediction 335
19. 15. Analyzing, searching, and annotating recurrent RNA three-dimensional motifs 363
20. Index 399