2 Single Nucleotide Polymorphisms in the Human KLK Locus and Their Implication in Various Diseases

Chapters in this book

1. Frontmatter i
2. Preface v
3. List of contributing authors vii
4. Table of Contents xi
5. Introduction to Volume 1: Kallikrein-related Peptidases. Characterization, Regulation, and Interactions Within the Protease Web 1
6. 1 Genomic Structure of the KLK Locus 5
7. 2 Single Nucleotide Polymorphisms in the Human KLK Locus and Their Implication in Various Diseases 31
8. 3 Evolution of Kallikrein-related Peptidases 79
9. 4 Structural Aspects of Kallikrein-related Peptidases 97
10. 5 Molecular Recognition Properties of Kallikrein-related Peptidases on Synthetic and Endogenous Substrates 117
11. 6 Natural, Engineered and Synthetic Inhibitors of Kallikrein-related Peptidases 141
12. 7 Kallikrein-related Peptidases as Pharmaceutical Targets 161
13. 8 Expression of Kallikrein-related Peptidases under (Patho-)Physiological Conditions 187
14. 9 Kallikrein-related Peptidases within the Proteolytic Web 251
15. 10 Kallikrein-Kinin Cascade: Bioregulation by Human Tissue Kallikrein 1 (hK1, KLK1) 271
16. 11 Role of KLK4 in Dental Enamel Formation 295
17. 12 Kallikrein-related Peptidases and Semen 311
18. 13 Kallikrein-related Peptidases and Inhibitors of the Skin 329
19. 14 Physiological and Pathophysiological Roles of Kallikrein-related Peptidases in the Central Nervous System 349
20. 15 Kallikrein-related Peptidases (KLKs), Proteinase-mediated Signaling and Proteinase-activated Receptors (PARs) 373
21. Index 399