13 Poly(glycerol sebacate) – a revolutionary biopolymer
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Israd H. Jaafar
Abstract
Novel materials possessing physical, mechanical, and chemical properties similar to those found in vivo provide a potential platform for building artificial microenvironments for tissue engineering applications. Poly(glycerol sebacate) is one such material. It has tunable mechanical properties within the range of common tissue, and favorable cell response without surface modification with adhesive ligands, and biodegradability. In this chapter, an overview of the material is presented, focusing on synthesis, characterization, microfabrication, use as a substrate in in vitro mammalian cell culture, and degradation characteristics.
Abstract
Novel materials possessing physical, mechanical, and chemical properties similar to those found in vivo provide a potential platform for building artificial microenvironments for tissue engineering applications. Poly(glycerol sebacate) is one such material. It has tunable mechanical properties within the range of common tissue, and favorable cell response without surface modification with adhesive ligands, and biodegradability. In this chapter, an overview of the material is presented, focusing on synthesis, characterization, microfabrication, use as a substrate in in vitro mammalian cell culture, and degradation characteristics.
Chapters in this book
- Frontmatter I
- Contents V
- List of contributing authors XI
- 1 Introduction: biopolymers and biocomposites 1
- 2 Lignin-based polymers 27
- 3 Cellulose-based polymers 65
- 4 Plant oil-based polymers 113
- 5 Bio-based polyurethane aqueous dispersions 155
- 6 Soybean-based polymers and composites 189
- 7 Biodegradable polylactic acid (PLA) 209
- 8 Bio-based polyhydroxyalkanoates blends and composites 235
- 9 Biodegradable polycaprolactone (PCL) based polymer and composites 255
- 10 Biodegradable poly(butylene adipate-coterephthalate) (PBAT) 279
- 11 Bio-based polyamide 309
- 12 Biodegradable shape-memory polymers and composites 331
- 13 Poly(glycerol sebacate) – a revolutionary biopolymer 353
- Index 375
Chapters in this book
- Frontmatter I
- Contents V
- List of contributing authors XI
- 1 Introduction: biopolymers and biocomposites 1
- 2 Lignin-based polymers 27
- 3 Cellulose-based polymers 65
- 4 Plant oil-based polymers 113
- 5 Bio-based polyurethane aqueous dispersions 155
- 6 Soybean-based polymers and composites 189
- 7 Biodegradable polylactic acid (PLA) 209
- 8 Bio-based polyhydroxyalkanoates blends and composites 235
- 9 Biodegradable polycaprolactone (PCL) based polymer and composites 255
- 10 Biodegradable poly(butylene adipate-coterephthalate) (PBAT) 279
- 11 Bio-based polyamide 309
- 12 Biodegradable shape-memory polymers and composites 331
- 13 Poly(glycerol sebacate) – a revolutionary biopolymer 353
- Index 375
