Chapters in this book

1. Frontmatter i
2. Preface v
3. Contents ix
4. I. Brief History of the Chemical Study of Penicillin 1
5. II. The Earlier Investigations relating to 2-Pentenylpenicillin 10
6. III. The Chemistry of n-Amylpenicillin up to December 1943 38
7. IV. Status of the Research on the Structure of Benzylpenicillin in December 1943 52
8. V. Isolation and Characterization of the Various Penicillins 76
9. VI. Penillic Acids and Penillamines 106
10. VII. Review of Certain Investigations on the Structure of Benzylpenicillin during 1944-1945 144
11. VIII. Some Inactivation and Degradation Reactions not included in Chapters IV and VII 207
12. IX. Desthiobenzylpenicillin and Other Hydrogenolysis Products of Benzylpenicillin 243
13. X. The Thiocyanate Derivative of Benzylpenicillin Methyl Ester 269
14. XI. The X-Ray Crystallographic Investigation of the Structure of Penicillin 310
15. XII. Identification and Crystallography of Penicillins and Related Compounds by X-Ray Diffraction Methods 367
16. XIII. Infrared Spectroscopic Studies on the Structure of Penicillin 382
17. XIV. Other Physical Methods 415
18. XV. The Constitution of Penicillins 440
19. XVI. Penicillamine, Its Analogs and Homologs 455
20. XVII. Penilloaldehydes and Penaldic Acids 473
21. XVIII. The Penilloic and Penicilloic Acids and Their Derivatives and Analogs 535
22. XIX. Biosynthesis of Penicillins 657
23. XX. Chemical Modifications of Natural Penicillins 680
24. XXI. Oxazoles and Oxazolones 688
25. XXII. Attempted Syntheses of Penicillins 849
26. XXIII. The Condensation of Oxazolones and D-Penicillamine and the Resultant Antibiotic Activity 892
27. XXIV. Methyl Benzylpseudopenicillinate 909
28. XXV. Thiazolidines 921
29. XXVI. The Chemistry of β-Lactams 973
30. XXVII. The γ-Lactam of Benzylhomopenicilloic Acid and Related Compounds 1004
31. XXVIII. Synthetic Benzylpenicillin 1018
32. XXIX. Assay of Penicillins 1025
33. XXX. Appendix 1043
34. SUBJECT INDEX 1069