Chapters in this book

1. Frontmatter i
2. Contents vii
3. Acknowledgments ix
4. Abbreviations xi
5. Introduction 1
6. 1 Ethics and Economics of Longevity: is it right to study aging? 6
7. 2 Why Do We Age? 15
8. 3 Studying the Genetics of Human Longevity: centenarians and what we can learn from them 37
9. 4 Long-Lived Species and Longevity Mutants of Model Organisms 51
10. 5 What Is Aging (and How Can We Measure It)? biomarkers of aging and “quality of life” metrics 71
11. 6 Insulin Signaling, FOXO Targets, and the Regulation of Longevity and Reproduction 87
12. 7 Dietary Restriction: nutrient and genetic regulation of longevity and reproduction 107
13. 8 Taking out the Trash: molecular homeostasis in the regulation of longevity 137
14. 9 Powering Longevity: mitochondria’s role in aging and longevity 152
15. 10 Dracula and Wolverine: how DNA repair and cell replacement can help us live long 173
16. 11 Use It or Lose It: reproductive aging, the germline, and longevity 193
17. 12 Sex, Flies (and Worms), and Videotape: the battle of the sexes 214
18. 13 I See Dead Flies: neurons and sensory regulation of longevity 237
19. 14 Don’t You Forget about Me: what we are learning about cognitive aging and how to slow it 250
20. 15 Lamarck’s Revenge? Transgenerational inheritance, the “molecular clock,” and the epigenetic regulation of longevity 279
21. 16 Gut Feelings: the microbiome and aging 303
22. 17 Long Life in a Pill? the future of longevity: from bench to biotech 319
23. Notes 349
24. Index 417
25. A NOTE ON THE TYPE 441