Article
Publicly Available
Mechanism-based isolation and structures of some anticancer active natural products
-
A. A. L. Gunatilaka
, D. G. I. Kingston and R. K. Johnson
Published/Copyright:
January 1, 2009
Published Online: 2009-01-01
Published in Print: 1994-01-01
© 2013 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Preface
- 10.1351/pac199466101943
- 10.1351/pac199466101955
- 10.1351/pac199466101961
- Recent discoveries in the chemistry of natural products
- 10.1351/pac199466101975
- 10.1351/pac199466101983
- Synthetic and stereochemical aspects of pheromone chemistry
- Unnatural prostaglandins of biochemical and physiological significance
- 10.1351/pac199466102007
- 10.1351/pac199466102015
- The formation of benzophenanthridine alkaloids
- Higher-order cycloaddition reactions in natural product synthesis
- Natural products by enantioselective catalysis with transition metal compounds
- Asymmetric syntheses and lanthanide-induced CD studies of (24R and 24S) 5β-cholestane-3α,7α,12α,24,25-pentols
- 10.1351/pac199466102041
- Biosynthetic studies on taxol
- Stereocontrol using silicon: A synthesis of methyl (+)-nonactate
- Recent developments in the synthesis of drimane and lactarane sesquiterpenes
- Synthesis and CD spectral studies of some fused cholestenopyrimidines
- Synthesis of macrocyclic lactam/lactone derivatives having antimicrobial activity
- Enantioselective synthesis of alkaloids and carbohydrates via chemoenzymatic methods
- Application of the aza-Claisen rearrangement to the total synthesis of natural products: (-)-Isoiridomyrmecin
- Concise enantiospecific syntheses of α-hydroxy-β-amino acids and indolizidines of natural origin
- 10.1351/pac199466102079
- Synthetic studies on phenazine antibiotics and antheridic acid
- 10.1351/pac199466102087
- 10.1351/pac199466102091
- Total syntheses of strychnos alkaloids
- Synthesis and chemistry of the insect antifeedant azadirachtin
- 10.1351/pac199466102103
- Synthesis of heterocyclic natural products: Model studies towards diazonamide A
- 10.1351/pac199466102111
- Stereospecific addition of thiophenol to electron-deficient double bond and its application to natural product synthesis
- 10.1351/pac199466102119
- Experiments directed towards synthesis of complex glycosphinogolipids: Ganglioganglioside GQ1b1
- Diastereo- and enantioselective akaloid syntheses
- Studies on the total synthesis of manzamine A
- Novel methods for the synthesis of C-aryl glycoside natural products
- Biomimetic chemical transformation from simple indole alkaloids to Gelsemium alkaloids
- 10.1351/pac199466102143
- Use of the aryl groups as the carboxyl synthon. Application to the synthesis of some natural products containing hydroxyamino acid functions
- Combined directed ortho metalation-cross coupling strategies. Design for natural product synthesis
- 10.1351/pac199466102159
- N-acyliminium ion cyclisations in natural product chemistry: Synthesis of gelsemine
- 10.1351/pac199466102167
- Enzymatic synthesis of analogs of bacterial lipid A and design of biologically active LPS-antagonists and -mimetics
- Total synthesis of aryl C-glycoside antibiotics
- 10.1351/pac199466102179
- The chemistry of khat. An approach to the synthesis of euonyminol
- Synthesis of C-glycosyl compounds and other natural products from levoglucosenone
- Highlights in phytochemistry of hepaticae-biologically active terpenoids and aromatic compounds
- Second generation leukotriene biosynthesis inhibitors
- Discovery of potential antidepressant agents: Novel 3-arylpyrrolidines with dual mechanism of action on neurotransmission
- Chemistry in a salad bowl: Comparative organosulfur chemistry of garlic, onion and shiitake mushrooms
- The biosynthesis of pyoverdins
- Biorational design of herbicides: Synthesis of inhibitors of the PFP enzyme
- Enzyme-mediated regioselective acylation of polyhydroxylated natural products
- Mechanism-based isolation and structures of some anticancer active natural products
- Bioactive metabolites from marine invertebrates
- Bioactive compounds from marine sponges
- Search for new antifungal compounds from higher plants
- Structural studies on glycoprotein glycans
- Biomimetic synthesis of nazlinin and nitrarine
- Biotechnology and synthetic chemistry: Routes to clinically important natural products
- Structural and synthetic studies of pithomycolide
- Synthesis and cytotoxicity of natural (+)-duocarmycin A and its three possible stereoisomers
- Role of cell surface carbohydrates in malaria
- 10.1351/pac199466102263
- Microbial metabolites affecting lipid biosynthesis
- 10.1351/pac199466102271
- Recent studies on cytotoxic, anti-HIV and antimalarial agents from plants
- 10.1351/pac199466102287
- Alkaloids from plants of Madagascar in the treatment of drug-resistant Plasmodium malaria
- 10.1351/pac199466102295
- Secondary phytotoxic metabolites from pathogenic fungi: Structure, synthesis and activity
- Biosynthesis of the pigments of life. The mystery of the cyclisation and ring D-inversion in the formation of uroporphyrinogen III
- 10.1351/pac199466102307
- 10.1351/pac199466102311
- 10.1351/pac199466102315
- Synthesis of new antitumour anthracyclines: Derivatives bearing a fluorine substitution at position 8 or 10
- 10.1351/pac199466102323
- 10.1351/pac199466102327
- Total synthesis of yuehchukene
- Recent developments in iridoids chemistry
- Some recent isolation studies from potential insecticidal Piper species
- 10.1351/pac199466102343
- 10.1351/pac199466102347
- Bioactive natural products from Thai plants
- 10.1351/pac199466102357
- Molecular rearrangements in longipinane derivatives
- 10.1351/pac199466102365
- 10.1351/pac199466102369
- Constituents of some Asian medicinal plants
- 10.1351/pac199466102379
- Structure elucidation of xanthone derivatives with CD4-binding activity from Penicillium glabrum (Wehmer) Westling
- A transition from ionic to free-radical mechanisms in chemistry and enzymology
- Chemistry of the cytotoxic principles of the ma rine fungus Lignincola laevis
- Anthraquinones and chemotaxonomy of the asphodelaceae
- Multiple ionizations in proteins: Arsenical analogues of natural phosphates
- Anticoagulant activities of β-1,3-glucansulfates in dependence on their molecular weight
- Structure-activity relations of teratogenic natural products
- Biosynthesis of lactacystin, a novel microbial metabolite which induces differentiation of Neuro 2a cells, a mouse neuroblastoma cell line
- Formation of reactive intermediates by cytochrome P-450 mediated oxidation of the anticancer drug mitoxantrone
Articles in the same Issue
- Preface
- 10.1351/pac199466101943
- 10.1351/pac199466101955
- 10.1351/pac199466101961
- Recent discoveries in the chemistry of natural products
- 10.1351/pac199466101975
- 10.1351/pac199466101983
- Synthetic and stereochemical aspects of pheromone chemistry
- Unnatural prostaglandins of biochemical and physiological significance
- 10.1351/pac199466102007
- 10.1351/pac199466102015
- The formation of benzophenanthridine alkaloids
- Higher-order cycloaddition reactions in natural product synthesis
- Natural products by enantioselective catalysis with transition metal compounds
- Asymmetric syntheses and lanthanide-induced CD studies of (24R and 24S) 5β-cholestane-3α,7α,12α,24,25-pentols
- 10.1351/pac199466102041
- Biosynthetic studies on taxol
- Stereocontrol using silicon: A synthesis of methyl (+)-nonactate
- Recent developments in the synthesis of drimane and lactarane sesquiterpenes
- Synthesis and CD spectral studies of some fused cholestenopyrimidines
- Synthesis of macrocyclic lactam/lactone derivatives having antimicrobial activity
- Enantioselective synthesis of alkaloids and carbohydrates via chemoenzymatic methods
- Application of the aza-Claisen rearrangement to the total synthesis of natural products: (-)-Isoiridomyrmecin
- Concise enantiospecific syntheses of α-hydroxy-β-amino acids and indolizidines of natural origin
- 10.1351/pac199466102079
- Synthetic studies on phenazine antibiotics and antheridic acid
- 10.1351/pac199466102087
- 10.1351/pac199466102091
- Total syntheses of strychnos alkaloids
- Synthesis and chemistry of the insect antifeedant azadirachtin
- 10.1351/pac199466102103
- Synthesis of heterocyclic natural products: Model studies towards diazonamide A
- 10.1351/pac199466102111
- Stereospecific addition of thiophenol to electron-deficient double bond and its application to natural product synthesis
- 10.1351/pac199466102119
- Experiments directed towards synthesis of complex glycosphinogolipids: Ganglioganglioside GQ1b1
- Diastereo- and enantioselective akaloid syntheses
- Studies on the total synthesis of manzamine A
- Novel methods for the synthesis of C-aryl glycoside natural products
- Biomimetic chemical transformation from simple indole alkaloids to Gelsemium alkaloids
- 10.1351/pac199466102143
- Use of the aryl groups as the carboxyl synthon. Application to the synthesis of some natural products containing hydroxyamino acid functions
- Combined directed ortho metalation-cross coupling strategies. Design for natural product synthesis
- 10.1351/pac199466102159
- N-acyliminium ion cyclisations in natural product chemistry: Synthesis of gelsemine
- 10.1351/pac199466102167
- Enzymatic synthesis of analogs of bacterial lipid A and design of biologically active LPS-antagonists and -mimetics
- Total synthesis of aryl C-glycoside antibiotics
- 10.1351/pac199466102179
- The chemistry of khat. An approach to the synthesis of euonyminol
- Synthesis of C-glycosyl compounds and other natural products from levoglucosenone
- Highlights in phytochemistry of hepaticae-biologically active terpenoids and aromatic compounds
- Second generation leukotriene biosynthesis inhibitors
- Discovery of potential antidepressant agents: Novel 3-arylpyrrolidines with dual mechanism of action on neurotransmission
- Chemistry in a salad bowl: Comparative organosulfur chemistry of garlic, onion and shiitake mushrooms
- The biosynthesis of pyoverdins
- Biorational design of herbicides: Synthesis of inhibitors of the PFP enzyme
- Enzyme-mediated regioselective acylation of polyhydroxylated natural products
- Mechanism-based isolation and structures of some anticancer active natural products
- Bioactive metabolites from marine invertebrates
- Bioactive compounds from marine sponges
- Search for new antifungal compounds from higher plants
- Structural studies on glycoprotein glycans
- Biomimetic synthesis of nazlinin and nitrarine
- Biotechnology and synthetic chemistry: Routes to clinically important natural products
- Structural and synthetic studies of pithomycolide
- Synthesis and cytotoxicity of natural (+)-duocarmycin A and its three possible stereoisomers
- Role of cell surface carbohydrates in malaria
- 10.1351/pac199466102263
- Microbial metabolites affecting lipid biosynthesis
- 10.1351/pac199466102271
- Recent studies on cytotoxic, anti-HIV and antimalarial agents from plants
- 10.1351/pac199466102287
- Alkaloids from plants of Madagascar in the treatment of drug-resistant Plasmodium malaria
- 10.1351/pac199466102295
- Secondary phytotoxic metabolites from pathogenic fungi: Structure, synthesis and activity
- Biosynthesis of the pigments of life. The mystery of the cyclisation and ring D-inversion in the formation of uroporphyrinogen III
- 10.1351/pac199466102307
- 10.1351/pac199466102311
- 10.1351/pac199466102315
- Synthesis of new antitumour anthracyclines: Derivatives bearing a fluorine substitution at position 8 or 10
- 10.1351/pac199466102323
- 10.1351/pac199466102327
- Total synthesis of yuehchukene
- Recent developments in iridoids chemistry
- Some recent isolation studies from potential insecticidal Piper species
- 10.1351/pac199466102343
- 10.1351/pac199466102347
- Bioactive natural products from Thai plants
- 10.1351/pac199466102357
- Molecular rearrangements in longipinane derivatives
- 10.1351/pac199466102365
- 10.1351/pac199466102369
- Constituents of some Asian medicinal plants
- 10.1351/pac199466102379
- Structure elucidation of xanthone derivatives with CD4-binding activity from Penicillium glabrum (Wehmer) Westling
- A transition from ionic to free-radical mechanisms in chemistry and enzymology
- Chemistry of the cytotoxic principles of the ma rine fungus Lignincola laevis
- Anthraquinones and chemotaxonomy of the asphodelaceae
- Multiple ionizations in proteins: Arsenical analogues of natural phosphates
- Anticoagulant activities of β-1,3-glucansulfates in dependence on their molecular weight
- Structure-activity relations of teratogenic natural products
- Biosynthesis of lactacystin, a novel microbial metabolite which induces differentiation of Neuro 2a cells, a mouse neuroblastoma cell line
- Formation of reactive intermediates by cytochrome P-450 mediated oxidation of the anticancer drug mitoxantrone