Discovery of potential antidepressant agents: Novel 3-arylpyrrolidines with dual mechanism of action on neurotransmission

Articles in the same Issue

1. Preface
2. The invention of chemical reactions of relevance to the chemistry of natural products
3. The study of intramolecular dynamics by nuclear magnetic resonance
4. Perspectives in supramolecular chemistry: From molecular recognition towards self-organisation
5. Recent discoveries in the chemistry of natural products
6. Functional roles of natural products: The involvement of extended arrays of weak interactions in cooperative binding phenomena
7. The chemistry of some sponges and their symbionts
8. Synthetic and stereochemical aspects of pheromone chemistry
9. Unnatural prostaglandins of biochemical and physiological significance
10. Enhanced synthetic efficiency towards natural products via transition metal catalyzed reactions
11. Design and development of synthetic peptide antigens
12. The formation of benzophenanthridine alkaloids
13. Higher-order cycloaddition reactions in natural product synthesis
14. Natural products by enantioselective catalysis with transition metal compounds
15. Asymmetric syntheses and lanthanide-induced CD studies of (24R and 24S) 5β-cholestane-3α,7α,12α,24,25-pentols
16. The tandem cycloaddition chemistry of nitroalkenes
17. Biosynthetic studies on taxol
18. Stereocontrol using silicon: A synthesis of methyl (+)-nonactate
19. Recent developments in the synthesis of drimane and lactarane sesquiterpenes
20. Synthesis and CD spectral studies of some fused cholestenopyrimidines
21. Synthesis of macrocyclic lactam/lactone derivatives having antimicrobial activity
22. Enantioselective synthesis of alkaloids and carbohydrates via chemoenzymatic methods
23. Application of the aza-Claisen rearrangement to the total synthesis of natural products: (-)-Isoiridomyrmecin
24. Concise enantiospecific syntheses of α-hydroxy-β-amino acids and indolizidines of natural origin
25. A new synthetic approach to dendrobatid alkaloids
26. Synthetic studies on phenazine antibiotics and antheridic acid
27. A palladium catalyzed route to a benzofuran analogue of idolactam V (ILV): Effects on PKC isotype selectivity
28. The structure and reactivity of C60
29. Total syntheses of strychnos alkaloids
30. Synthesis and chemistry of the insect antifeedant azadirachtin
31. Di-2-ethylhexyl phthalate: A medical concern and a possible marker for chronic fatigue syndrome
32. Synthesis of heterocyclic natural products: Model studies towards diazonamide A
33. Synthesis, conformational and biological properties of lipophilic derivatives of gastrin and cholecystokinin peptides
34. Stereospecific addition of thiophenol to electron-deficient double bond and its application to natural product synthesis
35. Enantiocontrolled route to natural products using chiral equivalents of cyclopentenone and cyclohexenone
36. Experiments directed towards synthesis of complex glycosphinogolipids: Ganglioganglioside GQ1b1
37. Diastereo- and enantioselective akaloid syntheses
38. Studies on the total synthesis of manzamine A
39. Novel methods for the synthesis of C-aryl glycoside natural products
40. Biomimetic chemical transformation from simple indole alkaloids to Gelsemium alkaloids
41. Atropisomer-selective 1,1'-binaphthyl synthesis via chirality transfer from sulfur
42. Use of the aryl groups as the carboxyl synthon. Application to the synthesis of some natural products containing hydroxyamino acid functions
43. Combined directed ortho metalation-cross coupling strategies. Design for natural product synthesis
44. Asymmetric synthesis of natural products monitored by chiral sulfoxides
45. N-acyliminium ion cyclisations in natural product chemistry: Synthesis of gelsemine
46. Application of α-chloroglycine residues for the modification of oligopeptides
47. Enzymatic synthesis of analogs of bacterial lipid A and design of biologically active LPS-antagonists and -mimetics
48. Total synthesis of aryl C-glycoside antibiotics
49. Azabicyclo[3.2.1]octene derivatives obtained by rearrangement reactions in course of the catharanthine synthesis
50. The chemistry of khat. An approach to the synthesis of euonyminol
51. Synthesis of C-glycosyl compounds and other natural products from levoglucosenone
52. Highlights in phytochemistry of hepaticae-biologically active terpenoids and aromatic compounds
53. Second generation leukotriene biosynthesis inhibitors
54. Discovery of potential antidepressant agents: Novel 3-arylpyrrolidines with dual mechanism of action on neurotransmission
55. Chemistry in a salad bowl: Comparative organosulfur chemistry of garlic, onion and shiitake mushrooms
56. The biosynthesis of pyoverdins
57. Biorational design of herbicides: Synthesis of inhibitors of the PFP enzyme
58. Enzyme-mediated regioselective acylation of polyhydroxylated natural products
59. Mechanism-based isolation and structures of some anticancer active natural products
60. Bioactive metabolites from marine invertebrates
61. Bioactive compounds from marine sponges
62. Search for new antifungal compounds from higher plants
63. Structural studies on glycoprotein glycans
64. Biomimetic synthesis of nazlinin and nitrarine
65. Biotechnology and synthetic chemistry: Routes to clinically important natural products
66. Structural and synthetic studies of pithomycolide
67. Synthesis and cytotoxicity of natural (+)-duocarmycin A and its three possible stereoisomers
68. Role of cell surface carbohydrates in malaria
69. Bioactive phenolic compounds in traditional medicines
70. Microbial metabolites affecting lipid biosynthesis
71. Marine animal and terrestrial plant anticancer constituents
72. Recent studies on cytotoxic, anti-HIV and antimalarial agents from plants
73. Bioactive components from Ficus glomerata
74. Alkaloids from plants of Madagascar in the treatment of drug-resistant Plasmodium malaria
75. Recent results in the search for bioactive compounds from Turkish medicinal plants
76. Secondary phytotoxic metabolites from pathogenic fungi: Structure, synthesis and activity
77. Biosynthesis of the pigments of life. The mystery of the cyclisation and ring D-inversion in the formation of uroporphyrinogen III
78. Plant cell biotechnology for the production of secondary metabolites
79. New natural products from terrestrial medicinal plants and marine algae
80. The chemistry of fumonisins and related compounds. Fumonisins from Fusarium moniliforme: Chemistry, structure and biosynthesis
81. Synthesis of new antitumour anthracyclines: Derivatives bearing a fluorine substitution at position 8 or 10
82. Gas phase infrared spectroscopy in characterization of unsaturated natural products
83. Aframodial and other bioactive diterpenoids from Aframomum species
84. Total synthesis of yuehchukene
85. Recent developments in iridoids chemistry
86. Some recent isolation studies from potential insecticidal Piper species
87. Antifertility principles from Marsdenia tinctoria: Pharmacological and phytochemical studies
88. Biologically active constituents of tropical and subtropical plants
89. Bioactive natural products from Thai plants
90. Molecular rearrangements in derivatives of grandiflorenic acid [(-)-kaur-9(11),16-dien-19-oic acid]
91. Molecular rearrangements in longipinane derivatives
92. Erythromycin: New chemistry on an old compound
93. C45- and C50-carotenoids
94. Constituents of some Asian medicinal plants
95. Cytotoxic lignans from Haplophyllum species
96. Structure elucidation of xanthone derivatives with CD4-binding activity from Penicillium glabrum (Wehmer) Westling
97. A transition from ionic to free-radical mechanisms in chemistry and enzymology
98. Chemistry of the cytotoxic principles of the ma rine fungus Lignincola laevis
99. Anthraquinones and chemotaxonomy of the asphodelaceae
100. Multiple ionizations in proteins: Arsenical analogues of natural phosphates
101. Anticoagulant activities of β-1,3-glucansulfates in dependence on their molecular weight
102. Structure-activity relations of teratogenic natural products
103. Biosynthesis of lactacystin, a novel microbial metabolite which induces differentiation of Neuro 2a cells, a mouse neuroblastoma cell line
104. Formation of reactive intermediates by cytochrome P-450 mediated oxidation of the anticancer drug mitoxantrone