Discovery and development of new β-lactam antibiotics

Artikel in diesem Heft

1. Enzymic lipoxygenation of arachidonic acid: mechanism, inhibition, and role in eicosanoid biosynthesis
2. Crystallographic studies of the β-lactamases from B. cereus
3. Use of rationally designed inhibitors to study sterol and triterpenoid biosynthesis
4. Bacterial organomercury lyase: a protonolytic detoxification catalyst
5. Progress in natural product chemistry by the chiron and related approaches - synthesis of avermectin B1a
6. Structure, design, and synthesis of immunoactive peptides
7. Developments in the chemical synthesis of naturally occurring DNA and RNA sequences with normal and unusual linkages
8. Synthesis and analysis of (poly)peptides
9. Iterative butenolide construction of polypropionate chains. Application to an efficient synthesis of (+)(9S)-dihydroerythronolide A
10. Synthesis of natural products using chiral glycol precursors
11. Vitamin B12-mediated electrochemical reactions in the synthesis of natural products
12. Stereoselective synthesis of β,γ-unsaturated amino acids
13. Generation and trapping of α-oxa and oxo o-quinodimethanes for natural product synthesis
14. A synthesis of moenocinol from isoprenoid precursors
15. Synthesis and uses of azetidiniminium salts
16. Synthetic studies on a stereochemically complex natural product: designs for the total synthesis of (-)-tetrodotoxin
17. Interaction of polyamines, their protonated salts and metal complexes with nucleic acid fragments
18. De novo synthesis of carbohydrates and related natural products
19. Switch-functionalized systems in biomimetic chemistry
20. Protein crystallography, computer graphics and drug design
21. Chemoenzymatic synthesis of a gene for the interleukin-2 receptor
22. Recent advances in the study of the binding site of heparin to antithrombin
23. Muramyl-peptides
24. Modification of natural products to improve their biological properties
25. Structure-activity relationships of cephem analogs
26. Penems: some recent advances
27. Discovery and development of new β-lactam antibiotics
28. Chiral control of the Staudinger reaction