First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the Leishmania topoisomerase IB enzyme

Néstor M. Carballeira; Michelle Cartagena; Fengyu Li; Zhongfang Chen; Christopher F. Prada; Estefania Calvo-Alvarez; Rosa M. Reguera; Rafael Balaña-Fouce

doi:10.1351/PAC-CON-11-10-21

Startseite First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the Leishmania topoisomerase IB enzyme

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First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the Leishmania topoisomerase IB enzyme

Néstor M. Carballeira , Michelle Cartagena , Fengyu Li , Zhongfang Chen , Christopher F. Prada , Estefania Calvo-Alvarez , Rosa M. Reguera und Rafael Balaña-Fouce

Veröffentlicht/Copyright: 29. April 2012

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Aus der Zeitschrift Pure and Applied Chemistry Band 84 Heft 9

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Carballeira, Néstor M., Cartagena, Michelle, Li, Fengyu, Chen, Zhongfang, Prada, Christopher F., Calvo-Alvarez, Estefania, Reguera, Rosa M. and Balaña-Fouce, Rafael. "First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the Leishmania topoisomerase IB enzyme" Pure and Applied Chemistry, vol. 84, no. 9, 2012, pp. 1867-1875. https://doi.org/10.1351/PAC-CON-11-10-21

Carballeira, N., Cartagena, M., Li, F., Chen, Z., Prada, C., Calvo-Alvarez, E., Reguera, R. & Balaña-Fouce, R. (2012). First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the Leishmania topoisomerase IB enzyme. Pure and Applied Chemistry, 84(9), 1867-1875. https://doi.org/10.1351/PAC-CON-11-10-21

Carballeira, N., Cartagena, M., Li, F., Chen, Z., Prada, C., Calvo-Alvarez, E., Reguera, R. and Balaña-Fouce, R. (2012) First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the Leishmania topoisomerase IB enzyme. Pure and Applied Chemistry, Vol. 84 (Issue 9), pp. 1867-1875. https://doi.org/10.1351/PAC-CON-11-10-21

Carballeira, Néstor M., Cartagena, Michelle, Li, Fengyu, Chen, Zhongfang, Prada, Christopher F., Calvo-Alvarez, Estefania, Reguera, Rosa M. and Balaña-Fouce, Rafael. "First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the Leishmania topoisomerase IB enzyme" Pure and Applied Chemistry 84, no. 9 (2012): 1867-1875. https://doi.org/10.1351/PAC-CON-11-10-21

Carballeira N, Cartagena M, Li F, Chen Z, Prada C, Calvo-Alvarez E, Reguera R, Balaña-Fouce R. First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the Leishmania topoisomerase IB enzyme. Pure and Applied Chemistry. 2012;84(9): 1867-1875. https://doi.org/10.1351/PAC-CON-11-10-21

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Online erschienen: 2012-4-29

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Artikel in diesem Heft

Preface
Natural products from Brazilian biodiversity as a source of new models for medicinal chemistry
Bioactive cubitane diterpenoids from a Colombian gorgonian species of the genus Eunicea
Structure- and ligand-based drug design approaches for neglected tropical diseases
First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the Leishmania topoisomerase IB enzyme
Potent and selective 2-oxoamide inhibitors of phospholipases A2 as novel medicinal agents for the treatment of inflammatory diseases
Structural and functional impairments of polysialic acid (polySia)-neural cell adhesion molecule (NCAM) synthesized by a mutated polysialyltransferase of a schizophrenic patient
Balancing life with glycoconjugates: Monitoring unfolded protein response-mediated anti-angiogenic action of tunicamycin by Raman spectroscopy
Exploring metal-driven stereoselectivity of glycopeptides by free-energy calculations
Why are the low-energy protein normal modes evolutionarily conserved?
IUPAC/CITAC Guide: Investigating out-of-specification test results of chemical composition based on metrological concepts (IUPAC Technical Report)

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https://doi.org/10.1351/PAC-CON-11-10-21

Schlagwörter für diesen Artikel

alkynes; Leishmania donovani; lipids; methoxylated fatty acids; synthesis; topoisomerase IB

Artikel in diesem Heft

Preface
Natural products from Brazilian biodiversity as a source of new models for medicinal chemistry
Bioactive cubitane diterpenoids from a Colombian gorgonian species of the genus Eunicea
Structure- and ligand-based drug design approaches for neglected tropical diseases
First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the Leishmania topoisomerase IB enzyme
Potent and selective 2-oxoamide inhibitors of phospholipases A2 as novel medicinal agents for the treatment of inflammatory diseases
Structural and functional impairments of polysialic acid (polySia)-neural cell adhesion molecule (NCAM) synthesized by a mutated polysialyltransferase of a schizophrenic patient
Balancing life with glycoconjugates: Monitoring unfolded protein response-mediated anti-angiogenic action of tunicamycin by Raman spectroscopy
Exploring metal-driven stereoselectivity of glycopeptides by free-energy calculations
Why are the low-energy protein normal modes evolutionarily conserved?
IUPAC/CITAC Guide: Investigating out-of-specification test results of chemical composition based on metrological concepts (IUPAC Technical Report)