Article
Publicly Available
A human experimental bone pain model
-
Trine Andresen
Published/Copyright:
July 1, 2010
Introduction
Bone associated pain from, e.g., metastases is poorly understood. The aim of the study was to develop a human experimental model, which could evoke pain from the periosteum.
Method
Fourteen healthy males (mean age 25 years, range 21–34) were included. Each subject participated in two sessions where pressure pain thresholds (PPT) were estimated with different probe sizes. A computer controlled algometer was applied to the skin over right medial tibia and a handhold algometer over the left medial tibia. Stimulation was performed before and after local anaesthesia (LA) to estimate influence of skin. In addition test-retest variation was evaluated.
Results
For both algometers there was no major difference within subjects (ICC > 0.6) or between subjects (CV < 13%). Computer controlled algometer: For probe size 6mm there was a significant difference in PPT before and after LA (P=0.007). Probe size 8mm showed no significant difference before and after LA (P=0.19). No significant differences were seen between sessions for both probe sizes (6mm: P = 0.43; 8mm: P=0.32). Handhold algometer: No significant differences in PPT for any probe sizes (2, 4, 6, 8 and 10mm) were seen before and after LA (P=0.4; 0.2; 0.01; 0.08 and 0.5). For probe sizes 2 and 10mm there were no significant differences between sessions (P=0.2; 0.3). Probe sizes 4, 6 and 8mm showed significant differences in PPT between sessions (P=0.03; 0.045; 0.006) indicating bias of the method over time.
Conclusion
Both methods could reliably evoke experimental periosteum associated pain. The handhold algometer is in practice easier to use.
Published Online: 2010-07-01
Published in Print: 2010-07-01
© 2010 Scandinavian Association for the Study of Pain
Articles in the same Issue
- Editorial comment
- Functional brain imaging of acute postoperative pain
- Clinical pain research
- Brain activation due to postoperative pain from the right hand measured with regional cerebral blood flow using positron emission tomography
- Editorial comment
- Long-term low-dose transdermal buprenorphine therapy for chronic noncancer pain
- Original experimental
- A 6-months, randomised, placebo-controlled evaluation of efficacy and tolerability of a low-dose 7-day buprenorphine transdermal patch in osteoarthritis patients naïve to potent opioids
- Editorial comment
- Repeated nociceptive stimulation for detecting drug effects
- Original experimental
- The effects of gabapentin in human experimental pain models
- Editorial comment
- Whether the weather influences pain: High prevalence of chronic pain in Iceland and Norway: Common genes? Or lack of sunshine and vitamin D?
- Observational studies
- A population based study of the prevalence of pain in Iceland
- Editorial comment
- Swedish nurses are prone to chronic shoulder and back pain because of miserable working conditions and poor leadership?
- Observational studies
- Predicting of pain, disability, and sick leave regarding a non-clinical sample among Swedish nurses
- Abstracts
- Trigeminal neuralgia or odontogenic pain
- Abstracts
- What’s wrong with animal models of pain?
- Abstracts
- Immunotherapy for neuroblastoma elicits a complement dependent whole body allodynia
- Abstracts
- Pain mechanisms in animal models of rheumatoid arthritis
- Abstracts
- Translating basic research to pharmacological treatment of neuropathic pain
- Abstracts
- Free Poster Presentations: Forearm heat pain does not inhibit electrically induced tibialis anterior muscle pain
- Abstracts
- Offset analgesia evoked by non-contact thermal stimulator
- Abstracts
- Inhibition of FAAH reverses spinal LTP
- Abstracts
- Hyperexcitable C-nociceptors in human paroxysmal pain
- Abstracts
- Pain sensitivity and experimentally induced sensitization in red haired women
- Abstracts
- How are opioids used in Norway? Persistent use, utilization of depot formulation and age profile in non-palliation patients
- Abstracts
- To which extent does incident and persistent use of weak opioids predict problematic opioid use?
- Abstracts
- Is transdermal buprenorphine for chronic non-malignant pain used long term without co-medication with other potentially addictive drugs?
- Abstracts
- Prostaglandin E2 production in synovial tissue and acute postoperative pain after knee arthroscopy
- Abstracts
- Girl presenting with oesophageal spasm pain after fundoplication
- Abstracts
- Epidemiology of persistent postoperative pain: Association of persistent pain and sensory abnormalities
- Abstracts
- Cost–benefit of a 13-week multidiciplinary rehabilitation course for chronic non-malignant pain patients
- Abstracts
- A novel and effective treatment modality for medically unexplained pain
- Abstracts
- Somatocognitive therapy in the management of chronic gynaecological pain. A review of current approach and historical background
- Abstract
- The Manual Intervention Trial (MINT)—The effect of various combinations of naprapathic manual therapy. The study protocol of a randomized controlled trial
- Abstracts
- The experience of chronic pain, loss and grief
- Abstracts
- Effect of buprenorphine and fentanyl in experimental induced superficial, deep and hyperalgesic pain
- Abstract
- Pretreatment with opioids enhances afferent induced long-term potentiation in the rat dorsal horn
- Abstracts
- Pigs in pain—Porcine behavioural responses towards mechanical nociceptive stimulation directed at the hind legs
- Abstracts
- A human experimental bone pain model
Articles in the same Issue
- Editorial comment
- Functional brain imaging of acute postoperative pain
- Clinical pain research
- Brain activation due to postoperative pain from the right hand measured with regional cerebral blood flow using positron emission tomography
- Editorial comment
- Long-term low-dose transdermal buprenorphine therapy for chronic noncancer pain
- Original experimental
- A 6-months, randomised, placebo-controlled evaluation of efficacy and tolerability of a low-dose 7-day buprenorphine transdermal patch in osteoarthritis patients naïve to potent opioids
- Editorial comment
- Repeated nociceptive stimulation for detecting drug effects
- Original experimental
- The effects of gabapentin in human experimental pain models
- Editorial comment
- Whether the weather influences pain: High prevalence of chronic pain in Iceland and Norway: Common genes? Or lack of sunshine and vitamin D?
- Observational studies
- A population based study of the prevalence of pain in Iceland
- Editorial comment
- Swedish nurses are prone to chronic shoulder and back pain because of miserable working conditions and poor leadership?
- Observational studies
- Predicting of pain, disability, and sick leave regarding a non-clinical sample among Swedish nurses
- Abstracts
- Trigeminal neuralgia or odontogenic pain
- Abstracts
- What’s wrong with animal models of pain?
- Abstracts
- Immunotherapy for neuroblastoma elicits a complement dependent whole body allodynia
- Abstracts
- Pain mechanisms in animal models of rheumatoid arthritis
- Abstracts
- Translating basic research to pharmacological treatment of neuropathic pain
- Abstracts
- Free Poster Presentations: Forearm heat pain does not inhibit electrically induced tibialis anterior muscle pain
- Abstracts
- Offset analgesia evoked by non-contact thermal stimulator
- Abstracts
- Inhibition of FAAH reverses spinal LTP
- Abstracts
- Hyperexcitable C-nociceptors in human paroxysmal pain
- Abstracts
- Pain sensitivity and experimentally induced sensitization in red haired women
- Abstracts
- How are opioids used in Norway? Persistent use, utilization of depot formulation and age profile in non-palliation patients
- Abstracts
- To which extent does incident and persistent use of weak opioids predict problematic opioid use?
- Abstracts
- Is transdermal buprenorphine for chronic non-malignant pain used long term without co-medication with other potentially addictive drugs?
- Abstracts
- Prostaglandin E2 production in synovial tissue and acute postoperative pain after knee arthroscopy
- Abstracts
- Girl presenting with oesophageal spasm pain after fundoplication
- Abstracts
- Epidemiology of persistent postoperative pain: Association of persistent pain and sensory abnormalities
- Abstracts
- Cost–benefit of a 13-week multidiciplinary rehabilitation course for chronic non-malignant pain patients
- Abstracts
- A novel and effective treatment modality for medically unexplained pain
- Abstracts
- Somatocognitive therapy in the management of chronic gynaecological pain. A review of current approach and historical background
- Abstract
- The Manual Intervention Trial (MINT)—The effect of various combinations of naprapathic manual therapy. The study protocol of a randomized controlled trial
- Abstracts
- The experience of chronic pain, loss and grief
- Abstracts
- Effect of buprenorphine and fentanyl in experimental induced superficial, deep and hyperalgesic pain
- Abstract
- Pretreatment with opioids enhances afferent induced long-term potentiation in the rat dorsal horn
- Abstracts
- Pigs in pain—Porcine behavioural responses towards mechanical nociceptive stimulation directed at the hind legs
- Abstracts
- A human experimental bone pain model
