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Cord blood klotho levels are inversely associated with leptin in healthy Latino neonates at risk for obesity

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Veröffentlicht/Copyright: 12. April 2018
Journal of Pediatric Endocrinology and Metabolism
Aus der Zeitschrift Journal of Pediatric Endocrinology and Metabolism Band 31 Heft 5

Abstract

Background:

Klotho serum levels reflect nutritional state in adults including obesity and anorexia. The relationship between cord blood klotho levels at birth and parameters of growth including anthropometrics are not known.

Methods:

We evaluated the relationship between cord blood klotho, leptin and adipocyte hormones and infant, child and maternal anthropometrics and maternal depression in a cohort of 73 children. Non-parametric tests were used to assess differences between dichotomous and categorical predictors and klotho levels and Spearman’s rank coefficients were used to assess the relationship between klotho levels and continuous predictors. A multivariable log transformed linear regression model was used to test for independent predictors of serum klotho levels.

Results:

Mean klotho levels were 2864.9±1409.7 (pg/mL) in cord blood and we found no relationship with infant sex, delivery specifics including gestational age or anthropometrics at birth. There was similarly no association between klotho levels at birth and future obesity at age 2. Leptin levels at birth were inversely associated with klotho levels in multivariable models after adjusting for other covariates (p<0.01). Similarly, in multivariable models insulin levels were inversely correlated with klotho levels (p=0.03). Leptin levels in our cohort of at-risk infants were more than 50% higher than other studies with neonates.

Conclusions:

We found no associations between weight or length at birth or obesity in early childhood and cord blood klotho levels. Cord blood klotho levels were inversely correlated with leptin and insulin levels at birth and should be further investigated to better understand the inter-relationship between this hormone and key regulators of growth and adiposity.

Keywords: growth; klotho; Latino; leptin; neonate
Corresponding author: Janet M. Wojcicki, PhD MPH, Department of Pediatrics, University of California, 550 15th Street, 5th Floor, San Francisco, CA 94134-0136, USA, Phone: (+415) 476-2380

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: National Institute of Diabetes and Digestive and Kidney Diseases, Funder Id: 10.13039/100000062, Grant Number: 097458 (to J.M.W). NINDS (R01 NS092918 to D.B.D.).

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2017-9-11
Accepted: 2018-2-15
Published Online: 2018-4-12
Published in Print: 2018-5-24

©2018 Walter de Gruyter GmbH, Berlin/Boston

Artikel in diesem Heft

  1. Frontmatter
  2. Review
  3. Review and evaluation of patient-centered psychosocial assessments for children with central precocious puberty or early puberty
  4. Mini Review
  5. Childhood obesity: how long should we wait to predict weight?
  6. Original Articles
  7. Glycated hemoglobin A1c as a screening test for detecting type 2 diabetes mellitus in obese children and adolescents
  8. Effect of a multidisciplinary treatment program on eating behavior in overweight and obese preschool children
  9. Cord blood klotho levels are inversely associated with leptin in healthy Latino neonates at risk for obesity
  10. Still too little, too late? Ten years of growth hormone therapy baseline data from the NordiNet® International Outcome Study
  11. Body composition and metabolic health of young male adults with childhood-onset multiple pituitary hormone deficiency after cessation of growth hormone treatment
  12. Hematuria as an adverse outcome following provocative growth hormone stimulation testing in children
  13. Bone mineral density comparison of adolescents with constitutional thinness and anorexia nervosa
  14. Adult height in patients with familial male-limited precocious puberty and the role of an aromatase inhibitor in patient management
  15. Association between UCP polymorphisms and adipokines with obesity in Mexican adolescents
  16. Impact of childhood type 1 diabetes on maternal work-family relations
  17. Case Reports
  18. Hyperthyroidism in an infant of a mother with autoimmune hypothyroidism with positive TSH receptor antibodies
  19. Sanjad-Sakati syndrome with macrocytic anemia and failure to thrive: a case from South Jordan
  20. In iodine-induced thyrotoxicosis, steroid therapy today could keep the surgical knife at bay
  21. Graves’ disease following allogenic hematopoietic stem cell transplantation for severe aplastic anemia: case report and literature review
https://doi.org/10.1515/jpem-2017-0357
Schlagwörter für diesen Artikel
growth; klotho; Latino; leptin; neonate

Artikel in diesem Heft

  1. Frontmatter
  2. Review
  3. Review and evaluation of patient-centered psychosocial assessments for children with central precocious puberty or early puberty
  4. Mini Review
  5. Childhood obesity: how long should we wait to predict weight?
  6. Original Articles
  7. Glycated hemoglobin A1c as a screening test for detecting type 2 diabetes mellitus in obese children and adolescents
  8. Effect of a multidisciplinary treatment program on eating behavior in overweight and obese preschool children
  9. Cord blood klotho levels are inversely associated with leptin in healthy Latino neonates at risk for obesity
  10. Still too little, too late? Ten years of growth hormone therapy baseline data from the NordiNet® International Outcome Study
  11. Body composition and metabolic health of young male adults with childhood-onset multiple pituitary hormone deficiency after cessation of growth hormone treatment
  12. Hematuria as an adverse outcome following provocative growth hormone stimulation testing in children
  13. Bone mineral density comparison of adolescents with constitutional thinness and anorexia nervosa
  14. Adult height in patients with familial male-limited precocious puberty and the role of an aromatase inhibitor in patient management
  15. Association between UCP polymorphisms and adipokines with obesity in Mexican adolescents
  16. Impact of childhood type 1 diabetes on maternal work-family relations
  17. Case Reports
  18. Hyperthyroidism in an infant of a mother with autoimmune hypothyroidism with positive TSH receptor antibodies
  19. Sanjad-Sakati syndrome with macrocytic anemia and failure to thrive: a case from South Jordan
  20. In iodine-induced thyrotoxicosis, steroid therapy today could keep the surgical knife at bay
  21. Graves’ disease following allogenic hematopoietic stem cell transplantation for severe aplastic anemia: case report and literature review
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