Furan-containing thiacyanine analogs and their antimicrobial activity
-
I. Kortišová
,
P. Foltínová
Abstract
Condensation of quaternary 2-methylbenzothiazolium bromides with 5-(dialkylamino)furan-2-carbaldehydes afforded a series of new thiacyanine analogs. The compounds exhibit significant activities against several bacterial, yeast, and mould strains. Derivatives with dipropylamino substituents showed higher inhibitory effects than those with cyclic secondary amino groups. Hence, the biological activity may have been influenced by the lipophilicity of the compounds. The effect on growth and on the plastid system of the unicellular flagellate Euglena gracilis was also studied.
[1] Gavaghan, A. D. and Nunn, A. J., Pharm. Acta Helv. 47, 719 (1972). Search in Google Scholar
[2] Magdolen, P., Zahradník, P., and Foltínová, P., Pharmazie 55, 803 (2000). Search in Google Scholar
[3] Buffa, R., Zahradník, P., and Foltínová, P., Collect. Czech. Chem. Commun. 67, 1820 (2002). http://dx.doi.org/10.1135/cccc2002182010.1135/cccc20021820Search in Google Scholar
[4] Hrobárik, P., Zahradník, P., and Fabian, W. M. F., Phys. Chem. Chem. Phys. 6, 495 (2004). http://dx.doi.org/10.1039/b314150k10.1039/B314150KSearch in Google Scholar
[5] Sališová, M., Prokešová, M., Kubričanová, M., and Toma, Š., Chem. Pap. 47, 183 (1993). Search in Google Scholar
[6] Nazarova, Z. N. and Pustovarov, V. S., Khim. Geterotsikl. Soedin. 1969, 586. Search in Google Scholar
[7] Foltínová, P., Sutoris, V., and Blöckinger, G., Folia Microbiol. (Prague) 23, 225 (1978). 10.1007/BF02876583Search in Google Scholar PubMed
© 2006 Institute of Chemistry, Slovak Academy of Sciences
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Articles in the same Issue
- Carbon dioxide production in the oscillating Belousov—Zhabotinsky reaction with oxalic acid
- Potentiometric and thermodynamic studies of 3-methyl-1-phenyl-{p-[N-(pyrimidin-2-yl)-sulfamoyl]phenylazo}-2-pyrazolin-5-one and its metal complexes
- Spectral and electrochemical study of coordination molecules Cu4OX6L4: 3-Methylpyridine and 4-Methylpyridine Cu4OBrnCl(6−n)L4 complexes
- Anodic stripping voltammetric determination of lead and cadmium in soil extracts
- Gold and silver determination in Waters by SPHERON® Thiol 1000 preconcentration and ETAAS
- Syntheses, geometry optimization, and electronic structure of N-and C-substituted benzonaphthyridines
- Synthesis, spectral description, and lipophilicity parameters determination of phenylcarbamic acid derivatives with integrated N-phenylpiperazine moiety in the structure
- New methods in synthesis of acetylcholinesterase reactivators and evaluation of their potency to reactivate cyclosarin-inhibited AChE
- Furan-containing thiacyanine analogs and their antimicrobial activity
- Synthesis and biological activity of new 1,3,4-thiadiazole derivatives
- Synthesis and identification of immunogen medroxyprogesterone acetate residues in edible foods and preparation of the Antisera
- Synthesis and characterization of oligosalicylaldehyde-based epoxy resins
- Extracellular polysaccharides produced by acapsular mutant of Cryptococcus laurentii
- Liquid chromatography of synthetic polymers under limiting conditions of insolubility. I. Principle of the method
- Transport velocities of different particulate materials in pneumatic conveying
- Nitrous oxide emissions from waste incineration
