On the Design of an In-Line Control System for a Vial Freeze-Drying Process: The Role of Chamber Pressure
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Davide Fissore
This paper is focused on the design of an in-line control system for the freeze-drying process of pharmaceuticals in a vial. The goal is to minimize the duration of the primary drying, when most of the water is removed by sublimation while maintaining the product temperature below the maximum value allowed by the product. The pressure in the drying chamber and the temperature of the fluid that is used to heat (or to cool) the product can be manipulated; the pressure rise test and the DPE (Dynamic Parameters Estimation) algorithm are used to estimate the product temperature and the residual ice fraction, i.e. the controlled variables. Both an open-loop controller, using constant values of fluid temperature and chamber pressure, and a closed-loop controller, based on the in-line optimization of the fluid temperature, will be described and tested. Finally, the possibility of manipulating in-line the pressure in the drying chamber will be discussed.
©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston
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Articles in the same Issue
- Article
- Process Modeling & Control: A Special Issue of Chemical Product & Process Modeling
- Determination of Kinetic and Stoichiometric Parameters of Pseudomonas putida F1 by Chemostat and In Situ Pulse Respirometry
- Exponential Observer Design for State Estimation in a Class of Anaerobic Sulfate Reducing Bioreactor
- From Reacting to Predicting Technologies: A Novel Performance Monitoring Technique Based on Detailed Dynamic Models
- Nonlinear Analysis of Heterogeneous Model for an Industrial Ammonia Reactor
- Iterative Design of Dynamic Experiments in Modeling for Optimization of Innovative Bioprocesses
- Dynamic Process and Accident Simulations as Tools to Prevent Industrial Accidents
- Modeling Disturbance Dynamics to Improve Controller Performance in Industrial Loops
- On the Design of an In-Line Control System for a Vial Freeze-Drying Process: The Role of Chamber Pressure
- A Takagi-Sugeno Fuzzy Dynamic Model of a Concentric-Tubes Heat Exchanger
- Design of Dynamics of a Recuperative Catalytic Combustor: Enhancement in Operation and Control
- Formulation and Spectral Reduction of the Dynamical Model of a Circulating Fluidized Bed Combustor
