Gold-coated lanthanide phosphate nanoparticles for an 225Ac in vivo alpha generator
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M. F. McLaughlin
Summary
Retaining radioactive daughter products at a clinically relevant target site remains one of the major challenges in development of in vivo α generators with radionuclides such as 225Ac and 223Ra. In this work, we examine the ability of layered nanoparticle constructs to retain 225Ac and the first decay daughter, 221Fr. Actinium-225 is cocrystalized in a lanthanide phosphate nanoparticle consisting of varying amounts of La and Gd. Additional lanthanide phosphate layers improve retention capability while an outer layer of gold facilitates the attachment of targeting moieties for in vivo use. Retention of 225Ac in the nanoparticles is near quantitative while the 221Fr retention varies from 60-89% as a function of time, the number of layers, and nanoparticle composition. Decay corrected radiochemical yield in the multi-shell syntheses are high (76%) and comparable to or better than existing delivery approaches.
© 2013 Oldenbourg Wissenschaftsverlag GmbH, Rosenheimer Str. 145, 81671 München
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Articles in the same Issue
- Measurement of bremsstrahlung-induced reaction cross-section for 93Nb using electron Linac
- Electrolytic partitioning of uranium and plutonium based on a new type of electrolytic mixer-settler
- Influence of humic acid on neptunium(V) sorption and diffusion in Opalinus Clay
- Quantum chemical study of inner-sphere complexes of trivalent lanthanide and actinide ions on the corundum (110) surface
- Synthesis and preliminary pharmacological evaluation of a new putative radioiodinated AMPA receptor ligand for molecular imaging
- Synthesis, radiolabeling and quality control of 111In-DOTA-bevacizumab for radioimmunoscintigraphy of VEGF receptors
- Isolation of hydroxytyrosol from olive leaves extract, radioiodination and investigation of bioaffinity using in vivo/in vitro methods
- Gold-coated lanthanide phosphate nanoparticles for an 225Ac in vivo alpha generator
- Interferences in instrumental neutron activation analysis by threshold reactions and uranium fission for miniature neutron source reactor
