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Cannabidiol effects on prepulse inhibition in nonhuman primates

  • Patricia G. Saletti EMAIL logo and Carlos Tomaz
Published/Copyright: May 24, 2018

Abstract

Prepulse inhibition (PPI) of acoustic startle reflex is a well-established behavior paradigm to measure sensorimotor gating deficits. PPI is disrupted in several neuropsychiatric disorders, including schizophrenia. PPI tests can be used to screen new drugs for treatment of such disorders. In this review, we discuss how PPI paradigm can help in screening the therapeutic effects of cannabidiol (CBD). We look into recent literature about CBD effects on PPI response in animal models, especially in nonhuman primates. CBD has been shown to modify PPI in N-methyl d-aspartate receptor antagonist models for schizophrenia, both in rodents and in nonhuman primates. These results show CBD as a potential drug for the treatment of neurologic disorders that present alterations in sensorimotor system, such as schizophrenia. Moreover, the PPI paradigm seems to be a useful and relative simple paradigm to test the efficacy of CBD as a potential therapeutic drug.

Acknowledgment

This work was supported by the Fundação de Apoio à Pesquisa do Distrito Federal (grant no. 193.000.033/2012) to C.T.

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Received: 2017-11-26
Accepted: 2018-03-29
Published Online: 2018-05-24
Published in Print: 2018-12-19

©2019 Walter de Gruyter GmbH, Berlin/Boston

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