Abstract
Sophisticated methods are currently used to investigate the properties of brain DNA and clarify its role under physiological conditions and in neurological and psychiatric disorders. Attention is now called on a DNA fraction present in the adult rat brain that is characterized by an elevated turnover and is not involved in cell division or DNA repair. The fraction, known as brain metabolic DNA (BMD), is modulated by strain, stress, circadian oscillations, exposure to enriched or impoverished environment, and notably by several training protocols and post-trial sleep. BMD is frequently localized in glial cells but is also present in neurons, often in the perinucleolar region. Its distribution in repetitive and non-repetitive DNA fractions shows that BMD differs from native DNA and that in learning rats its profile differs from that of control rats. More detailed knowledge of the molecular, cellular, and time-dependent BMD features will be necessary to define its role in memory acquisition and processing and in the pathogenesis of neurologic disorders.
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©2017 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Effect of acute stress on auditory processing: a systematic review of human studies
- Experimental spinal cord trauma: a review of mechanically induced spinal cord injury in rat models
- Brain metabolic DNA in memory processing and genome turnover
- Animal models of hypoxic-ischemic encephalopathy: optimal choices for the best outcomes
- Highway to thermosensation: a traced review, from the proteins to the brain
- Complex effects of apoplexy secondary to pituitary adenoma
- Regenerative peripheral neuropathic pain: novel pathological pain, new therapeutic dimension
- Possible role of biochemiluminescent photons for lysergic acid diethylamide (LSD)-induced phosphenes and visual hallucinations
- Therapeutic potential of flavonoids in spinal cord injury
- Is daily replication necessary when sampling cortisol concentrations in association studies of children with autism spectrum disorder? A systematic review and discussion paper
Articles in the same Issue
- Frontmatter
- Effect of acute stress on auditory processing: a systematic review of human studies
- Experimental spinal cord trauma: a review of mechanically induced spinal cord injury in rat models
- Brain metabolic DNA in memory processing and genome turnover
- Animal models of hypoxic-ischemic encephalopathy: optimal choices for the best outcomes
- Highway to thermosensation: a traced review, from the proteins to the brain
- Complex effects of apoplexy secondary to pituitary adenoma
- Regenerative peripheral neuropathic pain: novel pathological pain, new therapeutic dimension
- Possible role of biochemiluminescent photons for lysergic acid diethylamide (LSD)-induced phosphenes and visual hallucinations
- Therapeutic potential of flavonoids in spinal cord injury
- Is daily replication necessary when sampling cortisol concentrations in association studies of children with autism spectrum disorder? A systematic review and discussion paper