Serum α-klotho levels are not informative for the evaluation of growth hormone secretion in short children
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Cristina Meazza
Abstract
Background:
α-Klotho is a transmembrane protein that can be cleaved and act as a circulating hormone (s-klotho). s-Klotho serum levels seem to reflect growth hormone (GH) secretory status. We investigated the role of s-klotho as a reliable marker of GH secretion in short children and the factors influencing its secretion.
Methods:
We enrolled 40 short Egyptian children (20 GH deficiency [GHD] and 20 idiopathic short stature [ISS]). They underwent a pegvisomant-primed insulin tolerance test (ITT) and were accordingly reclassified as 16 GHD and 24 ISS. The samples obtained before and 3 days after pegvisomant administration, prior to the ITT, were used for assaying insulin-like growth factor (IGF)-I and s-klotho.
Results:
IGF-I and s-klotho serum levels were not significantly different (p=0.059 and p=0.212, respectively) between GHD and ISS. After pegvisomant, a significant reduction in IGF-I and s-klotho levels was found in both groups. s-Klotho significantly correlated only with IGF-I levels in both groups.
Conclusions:
s-Klotho mainly reflects the IGF-I status and cannot be considered a reliable biomarker for GH secretion in children.
Acknowledgments
The authors are grateful to Susan West for the English revision of the paper. The authors are grateful to Mr. Nino Sessa and Dr. Anna De Stefano for their technical assistance.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2017 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Review
- Individualised growth response optimisation (iGRO) tool: an accessible and easy-to-use growth prediction system to enable treatment optimisation for children treated with growth hormone
- Original Articles
- Relation of insulin resistance to neurocognitive function and electroencephalography in obese children
- Body weight misperception and health-related factors among Iranian children and adolescents: the CASPIAN-V study
- Do sufficient vitamin D levels at the end of summer in children and adolescents provide an assurance of vitamin D sufficiency at the end of winter? A cohort study
- Type 3 renal tubular acidosis associated with growth hormone deficiency
- Serum α-klotho levels are not informative for the evaluation of growth hormone secretion in short children
- Evaluation of neurodevelopment of children with congenital hypothyroidism by the Denver Developmental Screening Test
- Pediatric differentiated thyroid carcinoma: trends in practice and outcomes over 40 years at a single tertiary care institution
- Physical activity and bone mineral density at the femoral neck subregions in adolescents with Down syndrome
- A pilot study on the utility of reduced urine collection frequency protocols for the assessment of reproductive hormones in adolescent girls
- MODY in Ukraine: genes, clinical phenotypes and treatment
- A retrospective review of initial bisphosphonate infusion in an inpatient vs. outpatient setting for bisphosphonate naïve patients
- Molecular genetic and clinical delineation of 22 patients with congenital hypogonadotropic hypogonadism
- Letter to the Editor
- Rare cases of galactose metabolic disorders: identification of more than two mutations per patient
- Case Reports
- When one disease is not enough: succinyl-CoA: 3-oxoacid coenzyme A transferase (SCOT) deficiency due to a novel mutation in OXCT1 in an infant with known phenylketonuria
- Pseudohypoparathyroidism type 1B associated with assisted reproductive technology
- Long QT syndrome diagnosed in two sisters with propionic acidemia: a case report
- Delayed diagnosis of proopiomelanocortin (POMC) deficiency with type 1 diabetes in a 9-year-old girl and her infant sibling
Articles in the same Issue
- Frontmatter
- Review
- Individualised growth response optimisation (iGRO) tool: an accessible and easy-to-use growth prediction system to enable treatment optimisation for children treated with growth hormone
- Original Articles
- Relation of insulin resistance to neurocognitive function and electroencephalography in obese children
- Body weight misperception and health-related factors among Iranian children and adolescents: the CASPIAN-V study
- Do sufficient vitamin D levels at the end of summer in children and adolescents provide an assurance of vitamin D sufficiency at the end of winter? A cohort study
- Type 3 renal tubular acidosis associated with growth hormone deficiency
- Serum α-klotho levels are not informative for the evaluation of growth hormone secretion in short children
- Evaluation of neurodevelopment of children with congenital hypothyroidism by the Denver Developmental Screening Test
- Pediatric differentiated thyroid carcinoma: trends in practice and outcomes over 40 years at a single tertiary care institution
- Physical activity and bone mineral density at the femoral neck subregions in adolescents with Down syndrome
- A pilot study on the utility of reduced urine collection frequency protocols for the assessment of reproductive hormones in adolescent girls
- MODY in Ukraine: genes, clinical phenotypes and treatment
- A retrospective review of initial bisphosphonate infusion in an inpatient vs. outpatient setting for bisphosphonate naïve patients
- Molecular genetic and clinical delineation of 22 patients with congenital hypogonadotropic hypogonadism
- Letter to the Editor
- Rare cases of galactose metabolic disorders: identification of more than two mutations per patient
- Case Reports
- When one disease is not enough: succinyl-CoA: 3-oxoacid coenzyme A transferase (SCOT) deficiency due to a novel mutation in OXCT1 in an infant with known phenylketonuria
- Pseudohypoparathyroidism type 1B associated with assisted reproductive technology
- Long QT syndrome diagnosed in two sisters with propionic acidemia: a case report
- Delayed diagnosis of proopiomelanocortin (POMC) deficiency with type 1 diabetes in a 9-year-old girl and her infant sibling
