Medullary thyroid carcinoma: a review on ethical considerations in treatment of children

References

1. Cho YA, Kong SY, Shin A, Lee J, Lee EK, et al. Biomarkers of thyroid function and autoimmunity for predicting high-risk groups of thyroid cancer: a nested case – control study. BMC Cancer 2014;14:873.10.1186/1471-2407-14-873Search in Google Scholar PubMed PubMed Central

2. Kiess W, Penke M, Gesing J, Hoppmann J, Müller E, et al. Thyroid disorders revisited. J Pediatr Endocrinol Metab 2015;28:731–3.10.1515/jpem-2015-0251Search in Google Scholar PubMed

3. Davies L, Morris LG, Haymart M, Chen AY, Goldennberg D, et al. American Association of Clinical Endocrinologists and American College of Endocrinology disease state clinical review: the increasing of thyroid cancer. Endocr Pract 2015;21:686–96.10.4158/EP14466.DSCRSearch in Google Scholar PubMed PubMed Central

4. Agac Ay A, Kutun S, Cetin A. Are the characteristics of thyroid cancer different in young patients? J Pediatr Endocrinol Metab 2014;27:497–502.10.1515/jpem-2013-0192Search in Google Scholar PubMed

5. Arva NC, Deitch SG. Reclassification of cytologically atypical thyroid nodules based on radiologic features in pediatric patients. J Pediatr Endocrinol Metab 2015;28:753–60.10.1515/jpem-2014-0427Search in Google Scholar PubMed

6. Rajhbeharrysingh U, Taylor M, Milas M. Medical therapy for advanced forms of thyroid cancer. Surg Clin North Am 2014;94:541–71.10.1016/j.suc.2014.03.003Search in Google Scholar PubMed

7. Hedayati M, Nabipour I, Rezaei-Ghaleh N, Azizi F. Germline RET mutations in exons 10 and 11: an Iranian survey of 57 medullary thyroid carcinoma cases. Med J Malaysia 2006;61:564–9.Search in Google Scholar

8. Hedayati M, Zarif Yeganeh M, Sheikhol Eslami S, Rezgh Barez S, Hoghooghi Rad L, et al. Predominant RET germline mutations in exons 10, 11, and 16 in Iranian patients with hereditary medullary thyroid carcinoma. J Thyroid Res 2011;2011:264248.10.4061/2011/264248Search in Google Scholar PubMed PubMed Central

9. Ghazi AA, Bagheri M, Tabibi A, Sarvghadi F, Abdi H, et al. Multiple endocrine neoplasia type 2A in an Iranian family: clinical and genetic studies. Arch Iran Med 2014;17:378–82.Search in Google Scholar

10. Alvandi E, Akrami SM, Chiani M, Hedayati M, Nayer BN, et al. Molecular analysis of the RET proto-oncogene key exons in patients with medullary thyroid carcinoma: a comprehensive study of the Iranian population. Thyroid 2011;21:373–82.10.1089/thy.2010.0267Search in Google Scholar PubMed

11. Majidi M, Haghpanah V, Hedayati M, Khashayar P, Mohajeri-Tehrani MR, et al. A family presenting with multiple endocrine neoplasia type 2B: a case report. J Med Case Rep 2011;5:587.10.1186/1752-1947-5-587Search in Google Scholar PubMed PubMed Central

12. Sheikholeslami S, Zarif Yeganeh M, Hoghooghi Rad L, Golab Ghadaksaz H, Hedayati M, et al. Haplotype frequency of G691S/S904S in the RET proto-onco-gene in patients with medullary thyroid carcinoma. Iran J Publ Health 2014;43:235–40.Search in Google Scholar

13. Wells SA Jr., Asa SL, Dralle H, Elisei R, Evans DB, et al. Revised American Thyroid Association guidelines for the management of medullary thyroid carcinoma: the American Thyroid Association guidelines task force on medullary thyroid carcinoma. Thyroid 2015;25:567–610.10.1089/thy.2014.0335Search in Google Scholar PubMed PubMed Central

14. Jarzab B, Krajewska J, Wloch J, Wygoda Z. Clinical genetic of medullary thyroid carcinoma. Postêpy Nauk Medycznych 2015;1:38–46.Search in Google Scholar

15. Sippel RS, Kunnimalaiyaan M, Chen H. Current management of medullary thyroid cancer. Oncologist 2008;13:539–47.10.1634/theoncologist.2007-0239Search in Google Scholar

16. Dionigi G, Bianchi V, Rovera F, Boni L, Piantanida E, et al. Medullary thyroid carcinoma: surgical treatment advances. Expert Rev Anticancer Ther 2007;7:877–85.10.1586/14737140.7.6.877Search in Google Scholar

17. Lips CJ, Hoppener JW, Thijssen JH. Medullary thyroid carcinoma: role of genetic testing and calcitonin measurement. Ann Clin Biochem 2001;38:168–79.10.1258/0004563011900614Search in Google Scholar

18. Shuman AG, Shaha AR, Tuttle RM, Fins JJ, Morris LG. Medullary thyroid carcinoma: ethical issues for the surgeon. Ann Surg Oncol 2012;19:2102–7.10.1245/s10434-012-2235-4Search in Google Scholar

19. Macklin R. Ethical dilemmas in pediatric endocrinology: growth hormone for short normal children. J Pediatr Endocrinol Metab 2000;6:1349–52.10.1515/jpem-2000-s606Search in Google Scholar

20. Alonso Bedate C. Ethical and legal implications of the use of molecular biology in the clinic. J Pediatr Endocrinol Metab 2005;18:Suppl 1:1137–43.10.1515/JPEM.2005.18.S1.1137Search in Google Scholar

21. Lallier M, St-Vil D, Giroux M, Huot C, Gaboury L, et al. Prophylactic thyroidectomy for medullary thyroid carcinoma in gene carriers of MEN2 syndrome. J Pediatr Surg 1998;33:846–8.10.1016/S0022-3468(98)90656-XSearch in Google Scholar

22. Hahn M, Bishop J. Expression pattern of drosophila ret suggests a common ancestral origin between the metamorphosis precursors in insect endoderm and the vertebrate enteric neurons. Proc Natl Acad Sci USA 2001;98:1053–8.10.1073/pnas.98.3.1053Search in Google Scholar PubMed PubMed Central

23. Nakamura T, Ishizaka Y, Nagao M, Hara M, Ishikawa T. Expression of the ret proto-oncogene product in human normal and neoplastic tissues of neural crest origin. J Pathol 1994;172:255–60.10.1002/path.1711720305Search in Google Scholar PubMed

24. Machens A, Lorenz K, Dralle H. Constitutive RET tyrosine kinase activation in hereditary medullary thyroid cancer: clinical opportunities. J Intern Med 2009;266:114–25.10.1111/j.1365-2796.2009.02113.xSearch in Google Scholar PubMed

25. Spinelli C, Di Giacomo M, Costanzo S, Elisei R, Miccoli P. Role of RET codonic mutations in the surgical management of medullary thyroid carcinoma in pediatric age multiple endocrine neoplasm type2 syndromes. J Pediatr Surg 2010;45:1610–6.10.1016/j.jpedsurg.2010.03.019Search in Google Scholar PubMed

26. Unruh A, Fitze G, Jänig U, Bielack S, Lochbühler H, et al. Medullary thyroid carcinoma in a 2-month-old male with multiple endocrine neoplasia 2B and symptoms of pseudo-Hirschsprungdisease: a case report. J Pediatr Surg 2007;42:1623–6.10.1016/j.jpedsurg.2007.05.015Search in Google Scholar PubMed

27. Moore SW, Appfelstaedt J, Zaahl MG. Familial medullary carcinoma prevention, risk evaluation, and RET in children of families with MEN2. J Pediatr Surg 2007;42:326–32.10.1016/j.jpedsurg.2006.10.005Search in Google Scholar PubMed

28. Niccoli-Sire P, Murat A, Rohmer V, Franc S, Chabrier G, et al. Familial medullary thyroid carcinoma with non cysteine ret mutations: phenotype-genotype relationship in a large series of patients. J Clin Endocrinol Metab 2001;86:3746–53.10.1210/jcem.86.8.7767Search in Google Scholar PubMed

29. Abraham DT, Low TH, Messina M, Jackson N, Gill A, et al. Medullary thyroid carcinoma: longterm outcomes of surgical treatment. Ann Surg Oncol 2011;18:219–25.10.1245/s10434-010-1339-ySearch in Google Scholar PubMed

30. Wiench M, Woch J, Wygoda Z, Gubala E, Kula D, et al. Genetic diagnosis of multiple endocrine neoplasia type 2B. Endokrynologia Polska 2000;51:67–76.Search in Google Scholar

31. Roy M, Chen H, Sippel RS. Current understanding and management of medullary thyroid cancer. Oncologist 2013;18:1093–100.10.1634/theoncologist.2013-0053Search in Google Scholar PubMed PubMed Central

32. Bugalho MJ, Domingues R, Santos JR, Catarino AL, Sobrinho L. Mutation analysis of the RET proto-oncogene and early thyroidectomy: results of a Portuguese cancer centre. Surgery 2007;141:90–5.10.1016/j.surg.2006.03.025Search in Google Scholar PubMed

33. Wells SA Jr, Pacini F, Robinson BG, Santoro M. Multiple endocrine neoplasia type 2 and familial medullary thyroid carcinoma: an update. J Clin Endocrinol Metab 2013;98:3149–64.10.1210/jc.2013-1204Search in Google Scholar PubMed PubMed Central

34. Skinner MA, Moley JA, Dilley WG, Owzar K, Debenedetti MK, et al. Prophylactic thyroidectomy in multiple endocrine neoplasia type 2A. N Engl J Med 2005;353:1105–13.10.1056/NEJMoa043999Search in Google Scholar PubMed

35. Bütter A, Gagné J, Al-Jazaeri A, Emran MA, Deal C, et al. Prophylactic thyroidectomy in pediatric carriers of multiple endocrine neoplasia type 2A or familial medullary thyroid carcinoma: mutation in C620 is associated with Hirschsprung’s disease. J Pediatr Surg 2007;42:203–6.10.1016/j.jpedsurg.2006.09.019Search in Google Scholar PubMed

36. Elisei R, Romei C, Renzini G, Bottici V, Cosci B, et al. The timing of total thyroidectomy in RET gene mutation carriers could be personalized and safely planned on the basis of serum calcitonin: 18 years’ experience at one single center. J Clin Endocrinol Metab 2012;97:426–35.10.1210/jc.2011-2046Search in Google Scholar

37. Toledo SP, Cortina MA, Toledo Rde A, Lourenço DM Jr. Impact of RET proto oncogene analysis on the clinical management of multiple endocrine neoplasia type 2. Clinics 2006;61:59–70.10.1590/S1807-59322006000100011Search in Google Scholar

38. Rosenthal MS, Diekema DS. Pediatric ethics guidelines for hereditary medullary thyroid cancer. Int J Pediatr Endocrinol 2011;2011:847603.10.1155/2011/847603Search in Google Scholar

39. Harris M, Winship I, Spriggs M. Controversies and ethical issues in cancer-genetics clinics. Lancet Oncol 2005;6:301–10.10.1016/S1470-2045(05)70166-2Search in Google Scholar

40. Committee on bioethics; committee on genetics, and; American College of Medical Genetics and Genomics Social, Ethical, Legal; Issues Committee. Ethical and policy issues in genetic testing and screening of children. Pediatrics 2013;131:620–2.10.1542/peds.2012-3680Search in Google Scholar PubMed

41. Reilly PR, Boshar MF, Holtzman SH. Ethical issues in genetic research: disclosure and informed consent. Nat Genet 1997;15:16–20.10.1038/ng0197-16Search in Google Scholar PubMed

42. Nozhat Z, Hedayati M, Bozorgghalati F, Azizi F. Ethical guidelines and considerations in medical genetic researches. Int J Endocrinol Metab 2015;16:448–56.Search in Google Scholar

43. American Thyroid Association Guidelines Task Force, Kloos RT, Eng C, Evans DB, Francis GL, et al. Medullary thyroid cancer: management guidelines of the American Thyroid Association. Thyroid 2009;19:565–612.10.1089/thy.2008.0403Search in Google Scholar PubMed

44. Hodges FM, Svoboda JS, Van Howe RS. Prophylactic interventions on children: balancing human rights with public health. J Med Ethics 2002;28:10–6.10.1136/jme.28.1.10Search in Google Scholar PubMed PubMed Central

45. Mercurio MR. Adolescent’s refusal of treatment: principles in conflict. J Pediatr Endocrinol Metab 2008;21:3–6.10.1515/JPEM.2008.21.1.3Search in Google Scholar PubMed

46. Rodriguez-Sánchez A, López-Menchero C, Rodríguez-Arnao MD. Multiple endocrine neoplasia: paediatric perspective. J Pediatr Endocrinol Metab 2005;18(Suppl 1):1237–44.10.1515/JPEM.2005.18.S1.1237Search in Google Scholar

47. Roth R. Psychological and ethical aspects of prevention trials. J Pediatr Endocrinol Metab 2001;14:669–74.10.1515/JPEM.2001.14.S1.669Search in Google Scholar