Absence of a relationship between thyroid hormones and vitamin D levels
-
Ping Zhou
,
Jinny Cai
Abstract
Background: Vitamin D is an immune modulator that may play a role in thyroid related autoimmunity.
Methods: We analyzed a US population based dataset to determine the relationship between serum 25-hydroxyvitamin D (25OHD) and thyroid hormones while assessing the effects of autoimmunity and BMI.
Results: 25OHD did not correlate significantly with any thyroid related measure. 25OHD levels stratified by thyroid antibody status were not statistically different between antibody positive and negative groups. The mean 25OHD levels of lean, overweight, and obese groups defined by BMI were lower than those of the normal group. Only the mean thyroid stimulating hormone (TSH) value in the obese group was significantly higher than the normal group.
Conclusions: We conclude that thyroid related measures and 25OHD serum levels are not related.
Acknowledgments
We thank Ziyong Cai, PhD, for his valuable contributions to the statistical analyses performed in this study.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
References
1. Greer FR. Defining vitamin D deficiency in children: beyond 25-OH vitamin D serum concentrations. Pediatrics 2009;124:1471–3.10.1542/peds.2009-2307Search in Google Scholar PubMed
2. Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc 2006;81:353–73.10.4065/81.3.353Search in Google Scholar PubMed
3. Michalaki MA, Vagenakis AG, Leonardou AS, Argentou MN, Habeos IG, et al. Thyroid function in humans with morbid obesity. Thyroid 2006;16:73–8.10.1089/thy.2006.16.73Search in Google Scholar PubMed
4. Marras V, Casini MR, Pilia S, Carta D, Civolani P, et al. Thyroid function in obese children and adolescents. Horm Res Paediatr 2010;73:193–7.10.1159/000284361Search in Google Scholar PubMed
5. Cantorna MT, Zhu Y, Froicu M, Wittke A. Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system. Am J Clin Nutr 2004;80:1717S–20S.10.1093/ajcn/80.6.1717SSearch in Google Scholar PubMed
6. Tamer G, Arik S, Tamer I, Coksert D. Relative vitamin D insufficiency in Hashimoto’s thyroiditis. Thyroid 2011:21:891–6.10.1089/thy.2009.0200Search in Google Scholar PubMed
7. Goswami R, Marwaha RK, Gupta N, Tandon N, Sreenivas V, et al. Prevalence of vitamin D deficiency and its relationship with thyroid autoimmunity in Asian Indians: a community-based survey. Br J Nutr 2009;102:382–6.10.1017/S0007114509220824Search in Google Scholar PubMed
8. Aoki Y, Belin RM, Clickner R, Jeffries R, Phillips L, et al. Serum TSH and total T4 in the United States population and their association with participant characteristics: National Health and Nutrition Examination Survey (NHANES 1999-2002). Thyroid 2007;17: 1211–23.10.1089/thy.2006.0235Search in Google Scholar PubMed
9. Mazokopakis EE, Kotsiris DA. Hashimoto’s autoimmune thyroiditis and vitamin D deficiency. Current aspects. Hell J Nucl Med 2014;17:37–40.Search in Google Scholar
10. Choi YM, Kim WG, Kim TY, Bae SJ, Kim HK, et al. Low levels of serum vitamin D3 are associated with autoimmune thyroid disease in pre-menopausal women. Thyroid 2014;24: 655–61.10.1089/thy.2013.0460Search in Google Scholar PubMed PubMed Central
11. Mackawy AM, Al-Ayed BM, Al-Rashidi BM. Vitamin D deficiency and its association with thyroid disease. Int J Health Sci (Qassim) 2013;7:267–75.10.12816/0006054Search in Google Scholar PubMed PubMed Central
12. Shin DY, Kim KJ, Kim D, Hwang S, Lee EJ. Low serum vitamin D is associated with anti-thyroid peroxidase antibody in autoimmune thyroiditis. Yonsei Med J 2014;55:476–81.10.3349/ymj.2014.55.2.476Search in Google Scholar PubMed PubMed Central
13. Zaidman VE, Maceiras M, Lazzati JM, Kutasz EP, D’Isa G, et al. High prevalence of anti-thyroid antibodies associated with a low vitamin D status in a pediatric cohort. Clin Chem Lab Med 2014;52:e119–22.10.1515/cclm-2013-0975Search in Google Scholar PubMed
14. Camurdan OM, Döğer E, Bideci A, Celik N, Cinaz P. Vitamin D status in children with Hashimoto thyroiditis. J Pediatr Endocrinol Metab 2012;25:467–70.10.1515/jpem-2012-0021Search in Google Scholar
15. Bozkurt NC, Karbek B, Ucan B, Sahin M, Cakal E, et al.The association between severity of vitamin D deficiency and Hashimoto’s thyroiditis. Endocr Pract 2013;19:479–84.10.4158/EP12376.ORSearch in Google Scholar PubMed
16. Chailurkit LO, Aekplakorn W, Ongphiphadhanakul B. High vitamin D status in younger individuals is associated with low circulating thyrotropin. Thyroid 2013;23:25–30.10.1089/thy.2012.0001Search in Google Scholar PubMed
17. Smotkin-Tangorra M, Purushothaman R, Gupta A, Nejati G, Anhalt H, et al. Prevalence of vitamin D insufficiency in obese children and adolescents. J Pediatr Endocrinol Metab 2007;20:817–23.10.1515/JPEM.2007.20.7.817Search in Google Scholar PubMed
18. Alemzadeh R, Kichler J, Babar G, Calhoun M. Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season. Metabolism 2008;57:183–91.10.1016/j.metabol.2007.08.023Search in Google Scholar PubMed
19. Zhou P, Schechter C, Cai Z, Markowitz M. Determinants of 25(OH)D sufficiency in obese minority children: selecting outcome measures and analytic approaches. J Pediatr 2011;158:930–4.e1.10.1016/j.jpeds.2010.11.034Search in Google Scholar PubMed
20. Aypak C, Türedi O, Yüce A, Görpelioğlu S. Thyroid-stimulating hormone (TSH) level in nutritionally obese children and metabolic co-morbidity. J Pediatr Endocrinol Metab 2013;26:703–8.10.1515/jpem-2012-0384Search in Google Scholar PubMed
21. Dekelbab BH, Abou Ouf HA, Jain I. Prevalence of elevated thyroid-stimulating hormone levels in obese children and adolescents. Endocr Pract 2010;16:187–90.10.4158/EP09176.ORSearch in Google Scholar PubMed
©2016 by De Gruyter
Articles in the same Issue
- Frontmatter
- Review
- Medullary thyroid carcinoma: a review on ethical considerations in treatment of children
- Original Articles
- Monocyte chemoattractant protein 1 and macrophage migration inhibitory factor in children with type 1 diabetes
- Organ-specific autoimmunity in relation to clinical characteristics in children with long-lasting type 1 diabetes
- Seasonality of diagnosis of type 1 diabetes mellitus in the Netherlands (Young Dudes-2)
- Health-related quality of life in children and adolescents with type 1 diabetes mellitus from Montenegro: relationship to metabolic control
- Relation of fetuin A levels with cardiac, subcutaneous lipid accumulation and insulin resistance parameters in Turkish obese children
- Prooxidant-antioxidant balance in patients with phenylketonuria and its correlation to biochemical and hematological parameters
- Serum vaspin concentrations in girls with anorexia nervosa
- Effect of intramuscular cholecalciferol megadose in children with nutritional rickets
- Focus on BMI and subclinical hypothyroidism in adolescent girls first examined for amenorrhea or oligomenorrhea. The emerging role of polycystic ovary syndrome
- Absence of a relationship between thyroid hormones and vitamin D levels
- Parathyroid hormone-ionized calcium dynamics over the first year of life
- Biochemical markers of bone turnover in children with clinical bone fragility
- Adipocytokines and bone metabolism markers in relation to bone mineral values in early pubertal boys with different physical activity
- Bone mineral density in young Chilean patients with type 1 diabetes mellitus
- Case Reports
- A case of mature teratoma with a falsely high serum estradiol value measured with an immunoassay
- Leigh syndrome associated with a novel mutation in the COX15 gene
- More than one way to skin a thyroid. Managing pediatric hypothyroidism with weekly intramuscular levothyroxine
- First case report of rare congenital adrenal insufficiency caused by mutations in the CYP11A1 gene in the Czech Republic
- Arg924X homozygous mutation in insulin receptor gene in a Tunisian patient with Donohue syndrome
- Corrigendum
- Corrigendum to: Exposure to sunshine early in life prevented development of type 1 diabetes in Danish boys
Articles in the same Issue
- Frontmatter
- Review
- Medullary thyroid carcinoma: a review on ethical considerations in treatment of children
- Original Articles
- Monocyte chemoattractant protein 1 and macrophage migration inhibitory factor in children with type 1 diabetes
- Organ-specific autoimmunity in relation to clinical characteristics in children with long-lasting type 1 diabetes
- Seasonality of diagnosis of type 1 diabetes mellitus in the Netherlands (Young Dudes-2)
- Health-related quality of life in children and adolescents with type 1 diabetes mellitus from Montenegro: relationship to metabolic control
- Relation of fetuin A levels with cardiac, subcutaneous lipid accumulation and insulin resistance parameters in Turkish obese children
- Prooxidant-antioxidant balance in patients with phenylketonuria and its correlation to biochemical and hematological parameters
- Serum vaspin concentrations in girls with anorexia nervosa
- Effect of intramuscular cholecalciferol megadose in children with nutritional rickets
- Focus on BMI and subclinical hypothyroidism in adolescent girls first examined for amenorrhea or oligomenorrhea. The emerging role of polycystic ovary syndrome
- Absence of a relationship between thyroid hormones and vitamin D levels
- Parathyroid hormone-ionized calcium dynamics over the first year of life
- Biochemical markers of bone turnover in children with clinical bone fragility
- Adipocytokines and bone metabolism markers in relation to bone mineral values in early pubertal boys with different physical activity
- Bone mineral density in young Chilean patients with type 1 diabetes mellitus
- Case Reports
- A case of mature teratoma with a falsely high serum estradiol value measured with an immunoassay
- Leigh syndrome associated with a novel mutation in the COX15 gene
- More than one way to skin a thyroid. Managing pediatric hypothyroidism with weekly intramuscular levothyroxine
- First case report of rare congenital adrenal insufficiency caused by mutations in the CYP11A1 gene in the Czech Republic
- Arg924X homozygous mutation in insulin receptor gene in a Tunisian patient with Donohue syndrome
- Corrigendum
- Corrigendum to: Exposure to sunshine early in life prevented development of type 1 diabetes in Danish boys
