Electrical vestibular nerve stimulation as an adjunctive therapy in the management of type 2 diabetes

Sai Sailesh Kumar Goothy; Jason McKeown; Paul D. Mcgeoch; Srilatha B; Rajagopalan Vijayaraghavan; Ravikanth Manyam; Mahadik Vijay Khanderao

doi:10.1515/jbcpp-2020-0210

Article

Electrical vestibular nerve stimulation as an adjunctive therapy in the management of type 2 diabetes

Sai Sailesh Kumar Goothy , Jason McKeown , Paul D. Mcgeoch , Srilatha B , Rajagopalan Vijayaraghavan , Ravikanth Manyam and Mahadik Vijay Khanderao

Published/Copyright: November 19, 2020

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From the journal Journal of Basic and Clinical Physiology and Pharmacology Volume 32 Issue 6

Abstract

Objectives

Vestibular nerve stimulation using the portable battery-operated vestibular nerve stimulator is a sophisticated method noninvasive, safe, and easy to operate. It was hypothesized that vestibular nerve stimulation is effective in the management of type 2 diabetes. Hence, the present study was undertaken to determine the effectiveness of vestibular nerve stimulation using portable battery-operated vestibular nerve stimulator in the management of diabetes.

Methods

The present study was a double-blind randomized controlled trial with 1:1 split between the control and experimental groups. A total of 30 participants with type 2 diabetes were part of the study after obtaining the written informed consent. After recording the baseline values, the vestibular nerve stimulation was administered to the participants in the intervention group for 90 days. Sham stimulation was administered to the control group for 90 days. Outcome measures were recorded after 30 days and after 90 days of the intervention in both the groups.

Results

There was significant decrease in the total body weight, fasting, postprandial blood glucose, glycosylated hemoglobin levels, leptin, very low density lipoproteins levels followed by the intervention. There was significant improvement in both spatial and verbal memory scores. Depression and stress scores and systolic blood pressure decreased and remained in normal limits.

Conclusions

The study results have proven multimodal action of vestibular stimulation. It not only acts on regulation of the glucose metabolism but also can regulate the autonomic activity and improve cognition and relieve stress. This is the interesting finding of our study, which needs detailed further research to support implementation of vestibular nerve stimulation as an adjunctive therapy in the management of diabetes.

Keywords: adjunctive therapy; type 2 diabetes; vestibular nerve stimulation

Corresponding author: Dr. Sai Sailesh Kumar Goothy, Department of Physiology, R.D.Gardi Medical College, Ujjain, India, Phone: +91 9061076459, E-mail: dr.saisailesh@gmail.com

Funding source: Neurovalance

Award Identifier / Grant number: The VeNS devices used in this study and the study

Research funding: The VeNS devices used in this study and the study funding were provided by Neurovalens, a UK Medical Device Company.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors state no conflict of interest.
Informed consent: Dr. Jason McKeown and Dr. Paul Mcgeoch are cofounders of Neurovalens, a medical device company that provided the VeNS devices used in the study. JM is CEO of Neurovalens and PDM is a nonexecutive director. They were involved in the design of the study but not in its execution.
Ethical approval: The present study protocol was approved by institutional ethics committee (VSR/EC/19/01).

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Received: 2020-07-18

Accepted: 2020-09-25

Published Online: 2020-11-19

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Articles in the same Issue

https://doi.org/10.1515/jbcpp-2020-0210

Keywords for this article

adjunctive therapy; type 2 diabetes; vestibular nerve stimulation