A one-year retrospective review of vitamin D level, bone profile, liver function tests and body mass index in children with cystic fibrosis in a children’s university hospital
-
Oneza Ahmareen
,
Michaela Pentony
Abstract
Background: Vitamin D deficiency is common in young cystic fibrosis (CF), and is due to the impaired absorption of fat-soluble vitamins, decreased sun exposure, and suboptimal intake of vitamins-containing foods and/or supplements. Given that childhood is a critical period for the accrual of bone mass, with 90% peak bone mass laid in the first two decades of life, it is essential that optimal vitamin D levels are achieved in this time frame.
Methods: We conducted a retrospective review from January 1, 2012 to January 1, 2013, through which we reviewed levels of vitamin D and correlated with bone profile, liver function tests, lung function, genotype, age, dual-energy X-ray absorptiometry scan and body mass index z score.
Results: Of the 95 children with CF, 6 were excluded due to incomplete data, bringing our study population to a total of 89 children. Results showed 77.5% vitamin D deficiency (mean 59.42 nmol/L). No significant statistical correlation was found between vitamin D and the parameters described. Protocol supplementation did not raise vitamin D to therapeutic level in 63.2% of the study population. Those with genotype delta 508 (homozygous/heterozygous) had 92% vitamin D deficiency.
Conclusions: We attribute the non-responder group to vitamin D to poor compliance. Compliance level could not be addressed because our study is a retrospective review. Thus, further research is needed to define implications of pulmonary exacerbations on vitamin D and vice versa. Doing so can help assess the implication of genotype influence on vitamin D.
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©2015 by De Gruyter
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Articles in the same Issue
- Frontmatter
- Review
- Confucian thoughts on special education in China: key thoughts and impact
- Original Articles
- Vision of Israeli physical therapy national directors on the future development of the profession
- Computer-aided animated gesture-driven facial model with speech synthesis
- Restless Legs Syndrome in adolescent school children in Belgaum city: a cross-sectional study
- A one-year retrospective review of vitamin D level, bone profile, liver function tests and body mass index in children with cystic fibrosis in a children’s university hospital
- Analysis of the positioning of the head, trunk, and upper limbs during gait in children with visual impairment
- Cultural translation of a domestic violence intervention for small children: key policy and practice directions
- Sense of coherence and WHOQoL among parents of children with ASD in Malaysia
- Phonetic environment of disfluencies in children with stuttering
- Parental perception of developmental vulnerability after inter-country adoption: a 10-year follow-up study: longitudinal study after inter-country adoption
- Quantitative analysis of static equilibrium in women after mastectomy
- The relationship between sports teachers’ reports, motor performance and perceived self-efficacy of children with developmental coordination disorders
- Case Report
- Ectrodactyly ectodermal dysplasia cleft lip/palate (EEC) syndrome in a family
