Dydrogesterone support following assisted reproductive technique (ART) reduces the risk of pre-eclampsia
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Anizah Bt Ali
Abstract
Background:
Pre-eclampsia (PE) contributes to poor maternal morbidity and mortality. Progesterone is hypothesised to reduce the risk of PE.
Aim:
To determine the effect of progestogen supplementation during assisted reproductive technique (ART) in reducing the incidence of PE.
Method:
A retrospective comparative analysis among 1140 pregnancies between January 2006 and March 2015 conducted in a tertiary centre. A total of 570 pregnancies who conceived following ART with progesterone supplementation (study group) and an age-matched spontaneous pregnancies, without progesterone supplementation (control group, n=570) were included in the analysis. The study group received progesterone support following ART or intrauterine insemination (IUI) until 14–16 weeks’ gestation.
Results:
The rate of PE was significantly lower in the study group compared to control group (8.4% vs. 14.2%, p<0.05). Women supplemented with dydrogesterone only showed a lower PE incidence as compared to women received a combination of dydrogesterone and hydroxyprogesterone caproate, however, it was not statistically significant (6.9% vs. 9.9%; 6.9%; p=0.2).
Acknowledgments
The research team would like to thank all the staff in the Medically Assisted Conception Centre (MAC), labour room and the Universiti Kebangsaan Malaysia Medical Centre for their co-operation during the data collection process. We declare no conflict of interest. This study was not funded.
Ethical approval: This is to certify that prior ethical approval was obtained from the Research and Ethical Committee, Faculty of Medicine, Universiti Kebangsaan Malaysia before the study was commenced with a ethic number of FF-2015-345.
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©2016 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Mini-Review Article
- Dydrogesterone and pre-term birth
- Case Reports
- Successful prevention of preeclampsia in a high-risk pregnancy using progestogen dydrogesterone: a clinical case
- Use of hydroxyprogesterone caproate to prevent preterm labour in uterine didelphys: a case report
- Original Articles
- Dydrogesterone support following assisted reproductive technique (ART) reduces the risk of pre-eclampsia
- Maternal obesity is associated with a low serum progesterone level in early pregnancy
Articles in the same Issue
- Frontmatter
- Mini-Review Article
- Dydrogesterone and pre-term birth
- Case Reports
- Successful prevention of preeclampsia in a high-risk pregnancy using progestogen dydrogesterone: a clinical case
- Use of hydroxyprogesterone caproate to prevent preterm labour in uterine didelphys: a case report
- Original Articles
- Dydrogesterone support following assisted reproductive technique (ART) reduces the risk of pre-eclampsia
- Maternal obesity is associated with a low serum progesterone level in early pregnancy
