Severe verapamil intoxication despite correct use of low-dose verapamil
-
Loes Mandigers
,
Pauline D.J. Bollen
Abstract
We report a case of an adult patient using chronic low-dose verapamil who developed severe verapamil intoxication. A 57-year-old male patient was presented at the emergency room after a collapse of unknown etiology. The airway was compromised, and thus, an endotracheal tube was inserted. The patient deteriorated hemodynamically. Because of verapamil use and bradycardia, verapamil intoxication was suspected. The treatment was supported with intravenous fluids, calcium, inotropes, and a transvenous pacemaker. The patient progressively developed circulatory shock. Verapamil intoxication was confirmed, and therapy was adjusted accordingly. Insulin and calcium infusion were intensified, and glucagon and Intralipid® infusion were initiated. With this therapy, the patient’s condition improved rapidly. We found different factors in this patient that could have precipitated this event such as diminished metabolism by cytochrome P450 iso-enzymes, a slightly diminished renal function with hypoalbuminemia, and interaction with other protein-binding drugs.
References
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©2016 by De Gruyter
Articles in the same Issue
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- Editorial
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- Mini Reviews
- Human genetics: international projects and personalized medicine
- Clinical implementation of pharmacogenetics
- Progress in pharmacogenetics: consortiums and new strategies
- Pharmacogenetics and pharmacogenomics as tools in cancer therapy
- Original Articles
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- Garlic capsule and selenium-vitamins ACE combination therapy modulate key antioxidant proteins and cellular adenosine triphosphate in lisinopril-induced lung damage in rats
- Case Report
- Severe verapamil intoxication despite correct use of low-dose verapamil
- Congress Abstracts
- VII Conference of the Spanish Pharmacogenetics and Pharmacogenomics Society (SEFF). “The role of pharmacogenetics and pharmacogenomics in the XXI century medicine: current state of the art and new challenges”
Articles in the same Issue
- Frontmatter
- Editorial
- The role of pharmacogenetics and pharmacogenomics in 21st-century medicine: state of the art and new challenges discussed in the VII Conference of the Spanish Pharmacogenetics and Pharmacogenomics Society (SEFF)
- Mini Reviews
- Human genetics: international projects and personalized medicine
- Clinical implementation of pharmacogenetics
- Progress in pharmacogenetics: consortiums and new strategies
- Pharmacogenetics and pharmacogenomics as tools in cancer therapy
- Original Articles
- Metabolism and metabolite profiles in vitro and in vivo of ospemifene in humans and preclinical species
- Involvement of MTHFR and TPMT genes in susceptibility to childhood acute lymphoblastic leukemia (ALL) in Mexicans
- Garlic capsule and selenium-vitamins ACE combination therapy modulate key antioxidant proteins and cellular adenosine triphosphate in lisinopril-induced lung damage in rats
- Case Report
- Severe verapamil intoxication despite correct use of low-dose verapamil
- Congress Abstracts
- VII Conference of the Spanish Pharmacogenetics and Pharmacogenomics Society (SEFF). “The role of pharmacogenetics and pharmacogenomics in the XXI century medicine: current state of the art and new challenges”
