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Solubility of Substances Related to Urolithiasis

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Chemistry International -- Newsmagazine for IUPAC
From the journal Chemistry International -- Newsmagazine for IUPAC Volume 25 Issue 3

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Solubility of Substances Related to Urolithiasis

Improved solubility predictions for substances precipitating from complex body fluids would be of great benefit, given that, for instance, over one million Australians are currently suffering from kidney stones, causing the health system direct identifiable costs of over $70 million a year. The prevention and treatment of crystal deposition in the human body are based on the understanding of the physico-chemical properties underlying the precipitation of the substances involved. Among these properties, the solubilities of the crystals are very important. In the scope of urolithiasis, there are more than 20 different types of kidney stones composed of calcium oxalate hydrates (mono-, di-, and trihydrate), ammonium magnesium phosphate (struvite), calcium phosphates (hydroxyapatite and brushite), uric acid and urates, cystine, and xanthine. Solubilities of these substances can be incorporated in databases of sophisticated software packages that permit solubility calculations in artificial urine solutions. The results of these simulations would lead to some understanding and/or useful suggestions regarding the cause, prevention, and treatment of renal or bladder calculi. In any case, proper modelling of the solubilities of these substances requires reliable solubility constants. Thus, it is necessary to critically assess the literature values reported for these substances. Recently, a review on this subject was published in PAC, Vol. 73, pp. 785-797 (2001).

www.iupac.org/projects/2002/2002-035-1-500.html

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Published Online: 2009-09-01
Published in Print: 2003-05

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https://doi.org/10.1515/ci.2003.25.3.15b

Articles in the same Issue

  1. From the Editor
  2. Contents
  3. A Challenge to the World’s Scientists
  4. Discover Chemistry in Europe
  5. Philosophy of Chemistry
  6. Countdown to Ottawa
  7. David Shaw Appointed to J. Phys. Chem. Ref. Data Editorial Board
  8. Data for Science and Technology
  9. Physical and Engineering Science in Health Care
  10. Boletin Electronico Latinoamericano
  11. Atmospheric Deposition and Its Impact on Ecosystems
  12. 2004 ICSU Grants Program–IUPAC Applications
  13. Interdisciplinary Harmonized Approach to Metrological Traceability of Chemical Measurement Results
  14. Establishment of a System to Implement the Global Sharing of Chemical Education Reading Material with the Aid of Bi-Directional Machine Translation
  15. Toxicology Postgraduate Research in Developing Countries
  16. Women in Physics and Physical Science Network in Africa
  17. Foundation of an African Institute for Mathematical Sciences
  18. Solubility Data of Compounds Relevant to Human Health
  19. Solubility of Substances Related to Urolithiasis
  20. Solubility of Hydroxybenzoic Acids and Hydroxybenzoates
  21. Solubility of Haloganated Aromatic Hydrocarbons
  22. Recommended Values of the Viscosity of Molten Iron and Aluminum
  23. Postgraduate Course in Polymer Science
  24. Impact of Transgenic Crops on the Use of Agrochemicals and the Environment
  25. Provisional Recommendations
  26. Measurement of pH. Definition, Standards, and Procedures (IUPAC Recommendations 2002)
  27. Use of the Term "Recovery" and "Apparent Recovery" in Analytical Procedures (IUPAC Recommendations 2002)
  28. Impact of Scientific Developments on the Chemical Weapons Convention (IUPAC Technical Report)
  29. Critical Evaluation of Stability Constants and Thermodynamic Functions of Metal Complexes of Crown Ethers (IUPAC Technical Report)
  30. Critical Evaluation of the Chemical Properties of the Transactinide Elements
  31. Special Topic Articles Featuring the 2002 Winners of the IUPAC Prize for Young Chemists
  32. Polymer Science Insights
  33. Encouraging Independent Chemistry Learning Through Multimedia Design Experiences
  34. Scattering Methods for the Investigation of Polymers
  35. Acetonitrile Binary Systems
  36. Applications of Multiple Intelligences Theory to Chemistry Teaching and Learning
  37. Solid State Chemistry
  38. Photochemistry
  39. The Mission and Challenges of Polymer Science and Technology
  40. Polymer Characterization and Advanced Materials
  41. Bioinorganic Chemistry
  42. Degradation, Stabilization, and Recycling of Polymers
  43. Biological Inorganic Chemistry
  44. Molecular Characterization of Polymers
  45. Therapeutic Drug Monitoring and Clinical Toxicology
  46. Organic Chemistry
  47. Biodiversity and Natural Products
  48. Mycotoxins and Phycotoxins
  49. Polymers and Organic Chemistry
  50. Chemistry and Biological Chemistry of Vanadium
  51. Mark Your Calendar
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