Successful Drug Discovery
János Fischer and Wayne E. Childers (Eds)
Wiley-VCH, 2016, ISBN: 978-3-527-34115-3
The goal of this book series is to help experts in drug research and development, both in academia and industry, with case histories described by their key inventors or by recognized experts whose contributions can also serve as teaching examples.
Published in December 2016, Volume 2 retains the successful approach found in the previous volume: inventors and primary developers of drugs that made it to market tell the story of the drug’s discovery and development and relate the often twisted route from the first candidate molecule to the final marketed drug. Eleven selected case studies describe recently introduced drugs that have not been previously covered in textbooks or general references. These range across six different therapeutic fields and provide a representative cross-section of current drug development efforts. Sections include:
I. HDAC Inhibitor Anticancer Drug Discovery
II. Steroidal CYP17 Inhibitor Anticancer Drug Discovery
III. Anti-infective Drug Discoveries
IV. Central nervous system (CNS) Drug Discovery
V. Antiulcer Drug Discovery
VI. Cross Therapeutic Drug Discovery (Respiratory Diseases/Anticancer)
2016 marked the 10th anniversary of the approval of vorinostat, the first marketed histone deacetylase (HDCA) inhibitor. This event inaugurated a stream of HDAC inhibitor approvals and confirmed the validity of this drug target and of epigenetic modulation as a viable therapeutic mechanism. To celebrate this important milestone, Successful Drug Discovery presents a number of HDAC inhibitor drug discovery stories.
Backed by copious data and chemical information, the insight and experience of the contributors makes this volume one of the most useful training manuals that a junior medicinal chemist can hope to find. The book is the outcome of an IUPAC project.
See detailed Table of Contents on wiley.com.
©2017 by Walter de Gruyter Berlin/Boston
Articles in the same Issue
- Masthead - Full issue pdf
- Contents
- President’s Column
- On the Path to Rewarding Times
- Features
- Taking IUPAC Literally: Woodward’s Pure and Applied Chemistry Words
- The Periodic Table (continued?): Eka-francium Et Seq.
- Chemistry Organizations in a Changing World
- IUPAC Wire
- IUPAC and the Organisation for the Prohibition of Chemical Weapons Take Partnership to New Level
- IUPAC Announces the Names of the Elements 113, 115, 117, and 118
- IUPAC Periodic Table of the Elements—Updated Release
- Gender-based Harassment in the Practice of Science
- ICSU to Merge with ISSC
- Remembering Peter Greaves Taylor Fogg (1929-2016)
- Stamps International
- Woodward’s Birth Centennial
- Project Place
- Environmental Fate and Risks of Nano-enabled Pesticides
- Ecological Risk Assessment Workshop for Central America
- A Critical Review of Reporting and Storage of NMR Data for Spin-Half Nuclei in Small Molecules
- Guides in Metrology
- Bookworm
- Successful Drug Discovery
- Making an imPACt
- Source-based Nomenclature for Single-strand Homopolymers and Copolymers (IUPAC Recommendations 2016)
- Comprehensive Definition of Oxidation State (IUPAC Recommendations 2016)
- Glossary of Terms Used in Developmental and Reproductive Toxicology (IUPAC Recommendations 2016)
- IUPAC Provisional Recommendations
- Terminology of Bioanalytical Methods
- Nomenclature and Terminology for Dendrimers with Regular Dendrons and for Hyperbranched Polymers
- Conference Call
- WMFmeetsIUPAC
- Chemistry Education
- Green Chemistry
- Solid State Chemistry
- Where 2B & Y
- Macro- and Supramolecular Architectures and Materials
- POLYCHAR World Forum on Advanced Materials
- Coordination and Bioinorganic Chemistry
- Chemists and IUPAC: Taking Responsibility and Taking Action
- Small Satellites for Space Research
- Mark Your Calendar
Articles in the same Issue
- Masthead - Full issue pdf
- Contents
- President’s Column
- On the Path to Rewarding Times
- Features
- Taking IUPAC Literally: Woodward’s Pure and Applied Chemistry Words
- The Periodic Table (continued?): Eka-francium Et Seq.
- Chemistry Organizations in a Changing World
- IUPAC Wire
- IUPAC and the Organisation for the Prohibition of Chemical Weapons Take Partnership to New Level
- IUPAC Announces the Names of the Elements 113, 115, 117, and 118
- IUPAC Periodic Table of the Elements—Updated Release
- Gender-based Harassment in the Practice of Science
- ICSU to Merge with ISSC
- Remembering Peter Greaves Taylor Fogg (1929-2016)
- Stamps International
- Woodward’s Birth Centennial
- Project Place
- Environmental Fate and Risks of Nano-enabled Pesticides
- Ecological Risk Assessment Workshop for Central America
- A Critical Review of Reporting and Storage of NMR Data for Spin-Half Nuclei in Small Molecules
- Guides in Metrology
- Bookworm
- Successful Drug Discovery
- Making an imPACt
- Source-based Nomenclature for Single-strand Homopolymers and Copolymers (IUPAC Recommendations 2016)
- Comprehensive Definition of Oxidation State (IUPAC Recommendations 2016)
- Glossary of Terms Used in Developmental and Reproductive Toxicology (IUPAC Recommendations 2016)
- IUPAC Provisional Recommendations
- Terminology of Bioanalytical Methods
- Nomenclature and Terminology for Dendrimers with Regular Dendrons and for Hyperbranched Polymers
- Conference Call
- WMFmeetsIUPAC
- Chemistry Education
- Green Chemistry
- Solid State Chemistry
- Where 2B & Y
- Macro- and Supramolecular Architectures and Materials
- POLYCHAR World Forum on Advanced Materials
- Coordination and Bioinorganic Chemistry
- Chemists and IUPAC: Taking Responsibility and Taking Action
- Small Satellites for Space Research
- Mark Your Calendar
