Effect of dexamethasone, triiodothyronine and dimethyl-isopropyl-thyronine on lung maturation of the fetal rat lung
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S. Hundertmark
Abstract
Our purpose was to elucidate why clinical studies have up to now failed to demonstrate a positive effect of TRH combined with glucocorticosteroids on fetal lung maturity.
Morphological and biochemical lung maturation were determined by electron microscopy, choline incorporation, and surfactant-protein-A m-RNA synthesis in rat lung organoid cultures after exposure with a series of concentrations of dexamethasone, triiodothyronine, and dimethyl-isopropyl-thyronine.
Thyroid hormones improved morphogenesis of lung histotypic structures but had a negative effect on surfactant synthesis whereas glucocorticosteroids had a positive effect on the surfactant synthesis but a negative effect on morphogenesis. The combination of both substances even had the most negative effect on morphogenesis.
Since morphogenesis of lung histotypic structures is prerequisite for surfactant synthesis and secretion, we hypothesize that a sequential treatment of thyroid hormones to improve morphogenesis followed by the application of glucocorticosteroids might be an option to improve neonatal lung function.
Copyright (c)1999 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Measurement of the amniotic fluid index with and without Color Doppler
- Comparison of delayed absorbable suture v nonabsorbable suture for treatment of incompetent cervix
- Intra amniotic candidiasis. Case report and meta-analysis of 54 cases
- Factors relating to readmission of term and near term neonates in the first two weeks of life
- Congenital diaphragmatic hernia: Atypical presentation
- Real-time optical imaging of experimental brain ischemia and hemorrhage in neonatal piglets
- Ventricular dominance patterns in preterm infants
- One day old infant with acyanotic congenital heart disease: critical aortic stenosis
- Prenatal and perinatal risk factors for Tourette disorder
- The diagnostic role of "in utero” magnetic resonance imaging
- Effect of dexamethasone, triiodothyronine and dimethyl-isopropyl-thyronine on lung maturation of the fetal rat lung
- Yolk sac size and shape as predictors of poor pregnancy outcome
