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Transthyretin in Fish: State of the Art

  • Cecilia R.A. Santos , Liliana Anjos and Deborah M. Power
Published/Copyright: June 1, 2005
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Clinical Chemistry and Laboratory Medicine (CCLM)
From the journal Volume 40 Issue 12

Abstract

Relatively little is known about thyroid hormone-binding proteins in fish and, until recently, the thyroid hormones (THs), thyroxine (T4) and triiodothyronine (T3), had only been found in fish plasma bound to albumin and lipoproteins. Recently, transthyretin (TTR) was cloned in a teleost fish, the sea bream (sb); it is composed of 130 amino acids and shares 47–54% sequence similarity with other vertebrate TTR and binds preferentially T3. Homology modelling of sbTTR based upon the crystallographic structure of TTR in human, rat and chicken reveals similar monomer-monomer and dimer-dimer interfaces and a conserved tetrameric structure. In sbTTR, a single amino acid substitution in the thyroid hormone binding site (Ser 117 in human by Thr in sea bream) may explain the higher affinity of this tetramer for T3 rather than T4. The principal site of production of TTR in the sea bream is the liver but transcripts are also present in the intestine, brain, skin, heart, skeletal muscle, kidney, testis, gills and pituitary (in descending order of abundance). The function of TTR in fish remains to be studied but we have recently carried out studies which suggest it may be involved in TH balance during food shortage.

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Published Online: 2005-06-01
Published in Print: 2002-12-10

Copyright © 2002 by Walter de Gruyter GmbH & Co. KG

Articles in the same Issue

  1. Author Index
  2. Subject Index
  3. Contents
  4. Historical Aspects and Perspectives in Transthyretin Research
  5. Transthyretin from Discovery to Now
  6. The Evolution of Transthyretin Synthesis in Vertebrate Liver, in Primitive Eukaryotes and in Bacteria
  7. The Evolution of Transthyretin Synthesis in the Choroid Plexus
  8. Hepatic Synthesis, Maturation and Complex Formation between Retinol-Binding Protein and Transthyretin
  9. Synthesis and Structural Analysis of the N-Terminal Domain of the Thyroid Hormone-Binding Protein Transthyretin
  10. Three-Dimensional Structure of the Transthyretin-Retinol-Binding Protein Complex
  11. Mechanisms of Molecular Recognition: Crystal Structure Analysis of Human and Rat Transthyretin Inhibitor Complexes
  12. Transthyretin in Fish: State of the Art
  13. The Effects of Endocrine-Disrupting Chemicals on Thyroid Hormone Binding to Xenopus laevis Transthyretin and Thyroid Hormone Receptor
  14. Clinical Picture and Outcome of Transthyretin-Related Familial Amyloid Polyneuropathy (FAP) in Japanese Patients
  15. Laboratory Assessment of Transthyretin Amyloidosis
  16. Amyloid: Morphology and Toxicity
  17. Historical Overview of Analytical Methods for the Measurement of Transthyretin
  18. Nutritional Regulation of Visceral Markers in Rat Liver and Cultured Hepatoma Cells
  19. Significance of Transthyretin in Protein Metabolism
  20. Transthyretin as a Thyroid Hormone Carrier: Function Revisited
  21. The Molar Ratio of Retinol-Binding Protein to Transthyretin in the Assessment of Vitamin A Status in Adults. Proposal of a Cut-off Point
  22. Observations with Regard to the National Kidney Foundation K/DOQI Clinical Practice Guidelines Concerning Serum Transthyretin in Chronic Renal Failure
  23. Metabolism and Clinical Interest of Serum Transthyretin (Prealbumin) in Dialysis Patients
  24. Protein Status in Pancreatitis – Transthyretin Is a Sensitive Biomarker of Malnutrition in Acute and Chronic Pancreatitis
  25. Assessment of Nutritional Status in Organ Transplant: Is Transthyretin a Reliable Indicator?
  26. Body Composition and Nutritional Parameters in HIV and AIDS Patients
  27. C-Reactive Protein to Transthyretin Ratio for the Early Diagnosis and Follow-up of Postoperative Infection
  28. The Prognostic Value of Nutritional and Inflammatory Indices in Critically Ill Patients with Acute Respiratory Failure
  29. Transthyretin: Its Response to Malnutrition and Stress Injury. Clinical Usefulness and Economic Implications
  30. Transthyretin Measurement as a Screening Tool for Protein Calorie Malnutrition in Emergency Hospital Admissions
  31. Outcomes of Continuous Process Improvement of a Nutritional Care Program Incorporating TTR Measurement
  32. The Role of Visceral Protein Markers in Protein Calorie Malnutrition
  33. Acknowledgement
  34. Meetings
https://doi.org/10.1515/CCLM.2002.215

Articles in the same Issue

  1. Author Index
  2. Subject Index
  3. Contents
  4. Historical Aspects and Perspectives in Transthyretin Research
  5. Transthyretin from Discovery to Now
  6. The Evolution of Transthyretin Synthesis in Vertebrate Liver, in Primitive Eukaryotes and in Bacteria
  7. The Evolution of Transthyretin Synthesis in the Choroid Plexus
  8. Hepatic Synthesis, Maturation and Complex Formation between Retinol-Binding Protein and Transthyretin
  9. Synthesis and Structural Analysis of the N-Terminal Domain of the Thyroid Hormone-Binding Protein Transthyretin
  10. Three-Dimensional Structure of the Transthyretin-Retinol-Binding Protein Complex
  11. Mechanisms of Molecular Recognition: Crystal Structure Analysis of Human and Rat Transthyretin Inhibitor Complexes
  12. Transthyretin in Fish: State of the Art
  13. The Effects of Endocrine-Disrupting Chemicals on Thyroid Hormone Binding to Xenopus laevis Transthyretin and Thyroid Hormone Receptor
  14. Clinical Picture and Outcome of Transthyretin-Related Familial Amyloid Polyneuropathy (FAP) in Japanese Patients
  15. Laboratory Assessment of Transthyretin Amyloidosis
  16. Amyloid: Morphology and Toxicity
  17. Historical Overview of Analytical Methods for the Measurement of Transthyretin
  18. Nutritional Regulation of Visceral Markers in Rat Liver and Cultured Hepatoma Cells
  19. Significance of Transthyretin in Protein Metabolism
  20. Transthyretin as a Thyroid Hormone Carrier: Function Revisited
  21. The Molar Ratio of Retinol-Binding Protein to Transthyretin in the Assessment of Vitamin A Status in Adults. Proposal of a Cut-off Point
  22. Observations with Regard to the National Kidney Foundation K/DOQI Clinical Practice Guidelines Concerning Serum Transthyretin in Chronic Renal Failure
  23. Metabolism and Clinical Interest of Serum Transthyretin (Prealbumin) in Dialysis Patients
  24. Protein Status in Pancreatitis – Transthyretin Is a Sensitive Biomarker of Malnutrition in Acute and Chronic Pancreatitis
  25. Assessment of Nutritional Status in Organ Transplant: Is Transthyretin a Reliable Indicator?
  26. Body Composition and Nutritional Parameters in HIV and AIDS Patients
  27. C-Reactive Protein to Transthyretin Ratio for the Early Diagnosis and Follow-up of Postoperative Infection
  28. The Prognostic Value of Nutritional and Inflammatory Indices in Critically Ill Patients with Acute Respiratory Failure
  29. Transthyretin: Its Response to Malnutrition and Stress Injury. Clinical Usefulness and Economic Implications
  30. Transthyretin Measurement as a Screening Tool for Protein Calorie Malnutrition in Emergency Hospital Admissions
  31. Outcomes of Continuous Process Improvement of a Nutritional Care Program Incorporating TTR Measurement
  32. The Role of Visceral Protein Markers in Protein Calorie Malnutrition
  33. Acknowledgement
  34. Meetings
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