3 Extraction and bioprocessing with supercritical fluids
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José Coelho
Abstract
Supercritical fluid (SCF) technologies have emerged as a real alternative to various natural product extraction processes and pharmaceutical production to obtain micronized particles, coprecipitates, nanocomposite polymer structures and liposomes, in addition to other increasingly larger applications described in literature. In the present work, a brief literature review of the application of supercritical fluid extraction (SFE) is presented. This is evidenced by several publications and patents, contributions from several countries and the increase of industries around the world dedicated to this technique. Next, we aim to focus the analysis of SFE on a review of the literature applied to microalgae as a substitute primitive feedstock due to its high growth rate, valuable biologically active lipophilic substances, and photosynthetic efficiency without competition with food sources or needs of arable lands. We finally discussing an SCF bioprocess with a very new perspective for liposome production focalized on its potential at industrial scale.
Abstract
Supercritical fluid (SCF) technologies have emerged as a real alternative to various natural product extraction processes and pharmaceutical production to obtain micronized particles, coprecipitates, nanocomposite polymer structures and liposomes, in addition to other increasingly larger applications described in literature. In the present work, a brief literature review of the application of supercritical fluid extraction (SFE) is presented. This is evidenced by several publications and patents, contributions from several countries and the increase of industries around the world dedicated to this technique. Next, we aim to focus the analysis of SFE on a review of the literature applied to microalgae as a substitute primitive feedstock due to its high growth rate, valuable biologically active lipophilic substances, and photosynthetic efficiency without competition with food sources or needs of arable lands. We finally discussing an SCF bioprocess with a very new perspective for liposome production focalized on its potential at industrial scale.
Chapters in this book
- Frontmatter I
- Preface V
- Contents VII
- List of Contributing Authors XI
- 1 Chemical engineering methods in downstream processing in biotechnology 1
- 2 Separation of bio-products by liquid–liquid extraction 17
- 3 Extraction and bioprocessing with supercritical fluids 41
- 4 Ion exchange in downstream processing in biotechnology 63
- 5 Electro-membrane separations in biotechnology 79
- 6 Aqueous two-phase systems as a tool for bioseparation – emphasis on organic acids 95
- 7 Ionic liquid-assisted biphasic systems for downstream processing of fermentative enzymes and organic acids 123
- 8 Application of polymer membranes in downstream processes 155
- Index 165
Chapters in this book
- Frontmatter I
- Preface V
- Contents VII
- List of Contributing Authors XI
- 1 Chemical engineering methods in downstream processing in biotechnology 1
- 2 Separation of bio-products by liquid–liquid extraction 17
- 3 Extraction and bioprocessing with supercritical fluids 41
- 4 Ion exchange in downstream processing in biotechnology 63
- 5 Electro-membrane separations in biotechnology 79
- 6 Aqueous two-phase systems as a tool for bioseparation – emphasis on organic acids 95
- 7 Ionic liquid-assisted biphasic systems for downstream processing of fermentative enzymes and organic acids 123
- 8 Application of polymer membranes in downstream processes 155
- Index 165
