Section 2. Animal Models of Genetic Factors and Schizophrenia

Chapters in this book

1. Frontmatter i
2. CONTENTS vii
3. Foreword xi
4. Acknowledgments xiii
5. Introduction 1
6. Overview: Schizophrenia and the Lifetime Trajectory of Psychotic Illness: Developmental Neuroscience and Pathobiology, Redux 3
7. PART 1. Clinical Research on Risk Factors for Schizophrenia
8. Section 1. Environmental Factors: Epidemiologic Studies on the Etiologies of Schizophrenia
9. 1. Maternal Infection and Schizophrenia 25
10. 2. Prenatal Nutrition and the Etiology of Schizophrenia 58
11. 3. Obstetric Complications and Schizophrenia: Historical Overview and New Directions 96
12. 4. Maternal Stress During Pregnancy and Schizophrenia 120
13. 5. Advancing Paternal Age and the Risk for Schizophrenia 140
14. 6. Cannabis Use as a Component Cause of Schizophrenia 156
15. Section 2. Genetics and Epigenetics
16. 7. Schizophrenia Genetics: What Have We Learned from Genomewide Association Studies? 175
17. 8. Genetic Architecture of Schizophrenia: The Contribution of Copy Number Variation 210
18. 9. The Epigenetics of Schizophrenia 227
19. PART 2. Preclinical Research on Etiologies of Schizophrenia
20. Section 1. Animal Models of Environmental Factors and Schizophrenia
21. 10. Animal Models of the Maternal Infection Risk Factor for Schizophrenia 255
22. 11. Developmental Vitamin D Deficiency as a Risk Factor for Schizophrenia 282
23. 12. Animal Models of Prenatal Protein Malnutrition Relevant for Schizophrenia 300
24. 13. Animal Models of the Maternal Stress Risk Factor for Schizophrenia 335
25. Section 2. Animal Models of Genetic Factors and Schizophrenia 363
26. 14. DISC1: A New Paradigm for Schizophrenia and Biological Psychiatry 365
27. 15. Mutant Models of Nrg1 and ErbB4: Abnormalities of Brain Structures, Functions, and Behaviors Relevant to Schizophrenia 382
28. List of Contributors 413
29. Index 419