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Synthesis and Antimicrobial Activities of Oxazepine and Oxazocine Derivatives
-
Jian Tang
and
Yong-miao Shen
Published/Copyright:
June 2, 2014
A series of annulated 7-membered oxazepine and 8-membered oxazocine derivatives were synthesized by photoreaction of phthalimide derivatives and an alkene. The antimicrobial activities of the synthesized compounds were evaluated, and compounds 18 and 20 exhibited best antibacterial activity against Gram-positive bacteria. The relationships between structure (especially steric structure) and antimicrobial activities are discussed.
Received: 2014-2-6
Revised: 2014-6-21
Published Online: 2014-6-2
Published in Print: 2014-8-1
© 1946 – 2014: Verlag der Zeitschrift für Naturforschung
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Keywords for this article
Oxazepine;
Oxazocine;
Antimicrobial Activity;
Structure-Activity Relationship
Articles in the same Issue
- Excelsoside: A New Benzylic Diglycoside from the Leaves of Milicia excelsa
- Elatumic Acid: A New Ursolic Acid Congener from Omphalocarpum elatum Miers (Sapotaceae)
- Synthesis and Antimicrobial Activities of Oxazepine and Oxazocine Derivatives
- A New Isoxazolic Compound Acts as α7 Nicotinic Receptor Agonist in Human Umbilical Vein Endothelial Cells
- Water Stress Enhances Expression of Genes Encoding Plastid Terminal Oxidase and Key Components of Chlororespiration and Alternative Respiration in Soybean Seedlings
- Plant-Mediated Stereoselective Biotransformation of Phenylglyoxylic Acid Esters
- Spatiotemporal Expression Profile of the Pumilio Gene in the Embryonic Development of Silkworm
- In vitro Antiproliferative Effect of Helix aspersa Hemocyanin on Multiple Malignant Cell Lines
- (Z)-3-Dodecenoic Acid Is the Main Component of Full-Body n-Hexane Extracts from Two Acacia Gall-Inducing Thrips (Thysanoptera) and May Function as an Alarm Pheromone
- The Flavonols Quercetin, Myricetin, Kaempferol, and Galangin Inhibit the Net Oxygen Consumption by Immune Complex- Stimulated Human and Rabbit Neutrophils
