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Synthesis and evaluation of a collagen–brushite cement as a drug delivery system

Paper presented at the “VII International Congress of Biomaterials, BIOMAT'2018”, 14–16 March 2018, Havana, Cuba
  • Claudia Morilla , Yailene M. Lima , Gastón Fuentes and Amisel Almirall
Published/Copyright: April 3, 2019
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International Journal of Materials Research
From the journal International Journal of Materials Research Volume 110 Issue 4

Abstract

Calcium phosphate cements are known for their biocompatibility and bioactivity, which has led to a significant increase in their use. They have the advantage of being prepared as a malleable paste that sets in a few minutes and can be easily applied in bone defects. In this research work, 6 brushite cement formulations were prepared and the effect of collagen addition and the release of tetracycline were evaluated. All cements gave a malleable paste that set in 2 or 3 min, resulting in a material with pores of 5–20 μm. The cements showed compression resistance values between 0.8 and 1.7 MPa, and the addition of collagen was the most influential factor in the increase of this property. Up to 40 % of the drug was released after 7 days and the effectiveness of its antimicrobial activity was confirmed.

Keywords: Calcium phosphate cements; Brushite; Calcium phosphates; Collagen; Drug delivery system
∗Correspondence address, Dra. Amisel Almirall La Serna, Centro de Biomateriales, Universidad de La Habana, Avenida Universidad e/G y Ronda, Vedado, Plaza, La Habana 10400, Cuba, Tel: +53 7878 0687, e-mail: , Web: www.biomat.uh.cu

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Received: 2018-05-30
Accepted: 2018-10-26
Published Online: 2019-04-03
Published in Print: 2018-04-12

© 2019, Carl Hanser Verlag, München

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  3. Editorial
  4. “VII International Congress of Biomaterials, BIOMAT' 2018” (14–16 March 2018, Havana, Cuba): from medical devices to regenerative medicine
  5. Original Contributions
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  13. Effect of heat treatment on apatite coatings deposited on pre-calcified titanium substrates
  14. Calcium silicate-poly(n-butyl-2-cyanoacrylate) nanocomposite for bone tissue adhesion
  15. Synthesis and evaluation of a collagen–brushite cement as a drug delivery system
  16. Short Communications
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https://doi.org/10.3139/146.111751
Keywords for this article
Calcium phosphate cements; Brushite; Calcium phosphates; Collagen; Drug delivery system

Articles in the same Issue

  1. Contents
  2. Contents
  3. Editorial
  4. “VII International Congress of Biomaterials, BIOMAT' 2018” (14–16 March 2018, Havana, Cuba): from medical devices to regenerative medicine
  5. Original Contributions
  6. Microstructural evolution and strain hardening behavior of AISI 316L type austenitic stainless steel
  7. The microstructure and three-point bending behavior of Ni–Co/WC composite cladding coating
  8. Effects of TiN coating on the high-cycle-fatigue and very-high-cycle-fatigue properties of Ti-6Al-4V alloy
  9. Phase equilibria of the Dy–Nb–Si ternary system at 1 273 K
  10. Synthesis of SnO/SnO2 microsphere photocatalysts by ultrasonic reaction
  11. Exploring the use of silica sands and calcite from natural deposits to prepare bioactive glasses
  12. Bioactivity and mechanical properties of scaffolds based on calcium aluminate and bioactive glass
  13. Effect of heat treatment on apatite coatings deposited on pre-calcified titanium substrates
  14. Calcium silicate-poly(n-butyl-2-cyanoacrylate) nanocomposite for bone tissue adhesion
  15. Synthesis and evaluation of a collagen–brushite cement as a drug delivery system
  16. Short Communications
  17. Biomedical porous Ti-16Nb-10Zr-(0–15)Ta alloys
  18. Influence of Zr addition on the corrosion behavior of biomedical PIM Ti-16Nb alloy in SBF
  19. DGM News
  20. DGM News
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