Calculation of excitation functions for the production of Cu and Co medical isotopes
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Abstract
Copper and cobalt radioisotopes have been used for both diagnostic and therapeutic purposes in the field of nuclear medicine. There is considerable interest in 60,61,64,67Cu and 55,57Co radioisotopes for some applications like PET, SPECT imaging and targeted radiotherapy of tumors. In present study, the production of 60,61,64,67Cu and 55,57Co via 64Zn(p,α)61Cu, 67Zn(p,α)64Cu, 70Zn(p,α)67Cu, 58Ni(p,α)55Co, 60Ni(p,α)57Co, 64Zn(p,nα)6°Cu and 68Zn(p,nα)64Cu reactions have been investigated in the range of 5–40 MeV proton incident energy. The new version of the code ALICE-2011 is used to determine the excitation functions of these nuclear reactions. The calculated excitation functions were compared with experimental results and semi-empirical cross section values of a previously developed model.
Kurzfassung
Cu- und Co-Radioisotope werden in der Nuklearmedizin sowohl für diagnostische als auch für therapeutische Zwecke genutzt. Insbesondere 60,61,64,67Cu und 55,57Co Isotope sind von großem Interesse bei Anwendungen wie z.B. bei PET, SPECT Bildgebungsverfahren und der Strahlentherapie von Tumoren. In der vorliegenden Studie wird die Herstellung von 60,61,64,67Cu und 55,57Co via 64Zn(p,α)61Cu, 67Zn(p,α)64Cu, 70Zn(p,α)67Cu, 58Ni(p,α)55Co, 60Ni(p,α)57Co, 64Zn(p,nα)60Cu und 68Zn(p,nα)-64Cu-Reaktionen untersucht für Protonen im Energiebereich 5–40 MeV. Der neue Code ALICE 2011 wird zur Berechnung der Anregungsfunktionen dieser Kernreaktionen verwendet. Die berechneten Anregungsfunktionen wurden verglichen mit experimentellen Ergebnissen und semi-empirischen Wirkungsquerschnitten eines früher entwickelten Modells.
References
1 P. J.Blower; J. S.Lewis; J.Zweit: Copper radionuclides and radiopharmaceuticals in nuclear medicine. Nucl. Med. Biol.23 (1996) 957–8010.1016/S0969-8051(96)00130-8Search in Google Scholar
2 S. S.Gambhir: Molecular imaging of cancer with positron emission tomography. Nat. Rev. Cancer2(9) (2002) 684–9310.1038/nrc882Search in Google Scholar PubMed
3 G. C.Jayson; J.Zweit; A.Jackson; C.Mulatero; P.Julyan et al.: Molecular Imaging and Biological Evaluation of HuMV833 Anti-VEGF Antibody: Implications for Trial Design of Antiangiogenic Antibodies. J. Natl. Cancer Inst.94 (2002) 1484–9310.1093/jnci/94.19.1484Search in Google Scholar PubMed
4 H. A.Williams; S.Robinson; P.Julyan; J.Zweit; D.Hastings: A comparison of PET imaging characteristics of various copper radioisotopes. Eur. J. Nucl. Med. Mol. Imaging32 (2005) 1473–148010.1007/s00259-005-1906-9Search in Google Scholar PubMed
5 J.Zweit: Radionuclides and carrier molecules for therapy. Phys. Med. Biol.41 (1996) 1905–1410.1088/0031-9155/41/10/004Search in Google Scholar PubMed
6 S. V.Smith: Molecular imaging with copper-64. J. Inorg. Biochem.98 (2004) 1874–90110.1016/j.jinorgbio.2004.06.009Search in Google Scholar PubMed
7 R. B.Firestone; C. M.Baglin; S. Y. F.Chu: Update to the 8th Edition of the Table of Isotopes. Wiley, New York (1998)Search in Google Scholar
8 S. M.Qaim; T.Bisinger; K.Hilgers; D.Nayak; H. H.Coenen: Positron emission intensities in the decay of 64Cu, 76Br and 124I. Radiochim. Acta.95 (2007) 67–73Search in Google Scholar
9 S.Watanabe; Y.Iida; N.Suzui; T.Katabuchi; S.Ishii; N.Kawachi; H.Hanaoka; S.Matsuhashi; K.Endo; N. S.Ishioka: Production of no-carrier-added 64Cu and applications to molecular imaging by PET and PETIS as a biomedical tracer. J Radioanal Nucl Chem280 (2009) 199–205Search in Google Scholar
10 A. R.Jalilian; M.Nikzad; H.Zandi; A.Nemati Kharat; P.Rowshanfarzad; M.Akhlaghi; F.Bolourinovin: Preparation and evaluation of [61Cu]-thiophene-2-aldehyde thiosemicarbazone for PET studies. Nucl Med Rev11 (2008) 41–47Search in Google Scholar
11 J.De Reuck; P.Santens; K.Strijckmans; I.Lemahieu: Cobalt-55 positron emission tomography in vascular dementia: significance of white matter changes. J. Neurol. Sci.193 (2001) 1–6Search in Google Scholar
12 P.Goethals; A.Volkaert; C.Vandewielle; R.Dierckx; N.Lameire: 55Co-EDTA for renal imaging using positron emission tomography (PET): a feasibility study. Nucl. Med. Biol.27 (2000) 77–81Search in Google Scholar
13 S.Spellerberg; P.Reimer; G.Blessing; H. H.Coenen; S. M.Qaim: Production of 55Co and 57Co via Proton Induced Reactions on Highly Enriched 58Ni. Experimental study of excitation functions for the deuteron induced reactions 64Zn(d, 2p)64Cu and 64Zn(d, an)61Cu using the stacked foil technique. Appl. Radiat. Isot.66 (2008) 261–264.Search in Google Scholar
17 L.Daraban; R.Adam Rebeles; A.Hermanne: Study of the excitation function for the deuteron induced reaction on 64Ni(d,2n)for the production of the medical radioisotope 64Cu. Appl. Radiat. Isot.67 (2009) 506–510Search in Google Scholar
18 K.Abbas; J.Kozempel; M.Bonardi; F.Groppi; A.Alfarano; U.Holzwarth; F.Simonelli; H.Hofman; W.Horstmann; E.Menapace; L.Leseticky; N.Gibson: Cyclotron production of 64Cu by deuteron irradiation of 64Zn. Appl. Radiat. Isot.64 (2006) 1001–1005Search in Google Scholar
19 R. A.Rebeles; P.Van den Winkel; A.Hermanne; F.Tárkányi: New measurement and evaluation of the excitation function of 64Ni(p,n) reaction for the production of 64Cu. Nucl. Instrum. Meth. B267 (2009) 457–461Search in Google Scholar
20 F.Tarkanyi; F.Ditroi; S.Takacs; F.Szelecsenyi; A.Hermanne; M.Sonck: Activation cross-sections of alpha induced nuclear reactions on iron up to 40 MeV. Nucl. Instrum. Meth. B207 (2003) 381–394Search in Google Scholar
21 A.Aydın; B.Sarer; E.Tel: New calculation of excitation functions of proton-induced reactions in some medical isotopes of Cu, Zn and Ga. Appl. Radiat. Isot.65 (2007) 365–370Search in Google Scholar
22 E. G.Aydin; E.Tel; A.Kaplan; A.Aydin: New calculations of excitation functions of some positron emitting and single photon emitting radioisotopes. Kerntechnik73 (2008) 184–18910.3139/124.100563Search in Google Scholar
23 M.Blann; A. YuKonobeev; W. B.Wilson; S. G.Mashnik: Manual for Code Alice version July 7, (ALICE-2011 code) (2008)Search in Google Scholar
24 E.Tel; E. G.Aydin; A.Aydin; A.Kaplan; M. H.Bolukdemir; S.Okuducu: Investigation of Coulomb and Pairing Effects Using New Developed Empirical Formulas for Proton-Induced Reaction Cross Sections. Phys. Atom. Nucl.73 (2010) 412–41910.1134/S1063778810030038Search in Google Scholar
25 E.Tel; A.Aydin; E. G.Aydin; A.Kaplan; O.Yavas; I. A.Reyhancan: Newly developed semi-empirical formulas for (p, α) at 17.9 MeV and (p, np) at 22.3 MeV reaction cross-sections. Pramana- J. Phys.74 (2010) 931–94310.1007/s12043-010-0085-9Search in Google Scholar
26 EXFOR/CSISRS (Experimental Nuclear Reaction Data). Database Version of February 26, 2013, Brookhaven National Laboratory, National Nuclear Data Center, (http://www.nndc.bnl.gov/exfor/exfor00.htm) (2013)Search in Google Scholar
27 M.Blann: New precompound decay model. Phys. Rev. C54 (1996) 1341–134910.1103/PhysRevC.54.1341Search in Google Scholar PubMed
28 V. F.Weisskopf; D. E.Ewing: Statistical Compound Nucleus Model. Phys. Rev.57 (1940) 47210.1103/PhysRev.57.472Search in Google Scholar
29 N.Bohr; J. A.Wheeler: The mechanism of nuclear fission. Phys. Rev56 (1939) 426–45010.1103/PhysRev.56.426Search in Google Scholar
30 M. B.Chadwick; P.Oblozinsky: Continuum angular-distributions in preequilibrium nuclear reactions. Phys. Rev. C50 (1994) 2490–249310.1103/PhysRevC.50.2490Search in Google Scholar
31 M.Blann; H. K.Vonach: Global test of modified precompound decay models. Phys. Rev. C28 (1983) 147510.1103/PhysRevC.28.1475Search in Google Scholar
32 IAEA: Charged Particle Cross-section Database for Medical Radioisotope Production: Diagnostic Radioisotopes and Monitor Reactions. Co-ordinated Research Project, IAEA- TECDOC-1211, Vienna, Austria, May 2001, pp. 23–45. Available from: http://www-nds.iaea.org/medicalSearch in Google Scholar
33 M.Blann: Hybrid Model for Pre-Equilibrium Decay in Nuclear ReactionsPhys. Rev. Lett.27 (1971) 33710.1103/PhysRevLett.27.1550Search in Google Scholar
34 S. K.Kataria; V. S.Ramamurthy: Macroscopic systematics of nuclear level densitiesNucl. Phys. A349 (1980) 10–2810.1016/0375-9474(80)90440-6Search in Google Scholar
35 S.Takacs; F.Szelecsenyi; F.Tarkanyi; M.Sonck; A.Hermanne; Y.Shubin; A.Dityuk; M. G.Mustafa; Z.Youxiang: New cross-sections and intercomparison of deuteron monitor reactions on Al, Ti, Fe, Ni and Cu. Nucl. Instrum. Meth. B174 (2001) 235–25810.1016/S0168-583X(00)00589-9Search in Google Scholar
© 2013, Carl Hanser Verlag, München
Articles in the same Issue
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Articles in the same Issue
- Contents/Inhalt
- Contents
- Summaries/Kurzfassungen
- Summaries
- Technical Contributions/Fachbeiträge
- Development of inflatable seals for the rotatable plugs of sodium cooled fast breeder reactors: a review – Part II: R&D necessities and development across the world
- Analysis of radwaste management alternatives during dismantling of Ignalina NPP systems with low level contamination
- Calculation of excitation functions for the production of Cu and Co medical isotopes
- Reliability assessment of the passive heat removal system of the VVER-1000 reactor at Kudankulam NPP
- Calculation of the neutronic behavior of minor actinides burning in a thermal research reactor using the MCNPX 2.6 code
- Steam drum level control studies of a natural circulation multi loop reactor
- Analyses in regulatory practice
- Technical Notes/Technische Mitteilungen
- Installation and measurement capacity of 3 × 592 GBq 241Am–Be neutron irradiation cell
- Calculation of the critical thickness for one-speed neutrons in a reflected slab with backward and forward scattering using modified TN method