Rheological properties of functionalised thermosensitive copolymers for injectable applications in medicine
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Ivana Chamradová
,
Lucy Vojtová
Abstract
Functionalised triblock copolymers based on poly((lactic acid)-co-(glycolic acid)) and poly(ethylene glycol) (PLGA-PEG-PLGA) further modified with 3-methylenetetrahydrofuran-2,5-dione (itaconic anhydride; ITA) exhibited sol-gel transition induced by increasing temperature. Rheological properties of a series of ITA/PLGA-PEG-PLGA/ITA copolymer concentrations (6–24 mass %) in deionised Milli-Q water were studied by both the test tube inverting method (TTIM) and rheometer. The gel stiffness increased with the polymer concentration shifting the gel point of the copolymer to the lower temperature. The present study demonstrates that each method describes a sol-gel transition, but the combined method gives comprehensive information about changes in colour, viscosity, elastic and loss moduli. Characterisation of such a gel is necessary for its further use, in order to determine whether the material is appropriate as an injectable biomedical hydrogel.
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© 2012 Institute of Chemistry, Slovak Academy of Sciences
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Articles in the same Issue
- Development of polyaniline microarray electrodes for cadmium analysis
- Simultaneous determination of metal traces by ICP-MS in environmental waters using SPE preconcentration on different polymeric sorbents
- Identification of volatile aroma compounds in processed cheese analogues based on different types of fat
- Speciation of arsenic metabolites in the free-living mouse Mus spretus from Doñana National Park used as a bio-indicator for environmental pollution monitoring
- Fatty acid and phytosterol contents of some Romanian wild and cultivated berry pomaces
- Carotenoid and fatty acid profiles of bilberries and cultivated blueberries from Romania
- Changes in lipid composition of apple surface layer during long-term storage in controlled atmosphere
- Influence of various spices on acrylamide content in buckwheat ginger cakes
- Comparative analysis of lipophilic compounds in eggs of organically raised ISA Brown and Araucana hens
- Resistance of nanostructured films to permeation by industrial pollutants
- Comparison of linseed (Linum usitatissimum L.) genotypes with respect to the content of polyunsaturated fatty acids
- Rheological properties of functionalised thermosensitive copolymers for injectable applications in medicine
- Erratum to: “Csilla Mészárosová, Nadežda Kolarova, Renáta Vadkertiová, Eva Stratilová: Induction of Cryptococcus laurentii α-galactosidase”, Chemical Papers 66 (9) 806-813 (2012)
