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Mechanisms controlling lipid accumulation and polyunsaturated fatty acid synthesis in oleaginous fungi

  • Kobkul Laoteng EMAIL logo , Milan Čertík and Supapon Cheevadhanark
Published/Copyright: January 26, 2011
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Chemical Papers
From the journal Chemical Papers Volume 65 Issue 2

Abstract

Polyunsaturated fatty acids (PUFAs) are functional lipids that have been widely incorporated into several industrial sectors. Apart from animal- and plant-derived origins, oleaginous fungi belonging to Mucorales have been identified as promising alternatives for production of n-3 and n-6 PUFAs. It was found, in Mucorales fungi, that ATP:citrate lyase, acetyl-CoA carboxylase and malic enzyme trigger lipid overproduction, and biosynthesis of PUFA requires membrane-bound desaturases with fatty acyl substrate specificities. Accumulation of PUFAs in the cells is associated not only with the desaturation system, but it is also tightly bound with acyltransferases that facilitate the distribution of newly synthesized PUFA to individual lipid structures. Several physical parameters, such as temperature, aeration, and nutrient regimes, greatly affect either the lipid content or fatty acid composition among different Mucorales species. Conclusive evidence showed that the PUFA production yield of the fungi depends on the environmental control of “oleaginous” enzymes, and on the transcriptional expression of the desaturase genes. These valuable studies provide perspectives with biological rationale for microbial production of economically important lipids.

Keywords: polyunsaturated fatty acids; oleaginous fungi; fatty acid desaturation; lipid accumulation; gene expression

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Published Online: 2011-1-26
Published in Print: 2011-4-1

© 2011 Institute of Chemistry, Slovak Academy of Sciences

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  1. Mechanisms controlling lipid accumulation and polyunsaturated fatty acid synthesis in oleaginous fungi
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  3. New SPME fibre for analysis of mequinol emitted from DVDs
  4. Continuous production of citric acid from raw glycerol by Yarrowia lipolytica in cell recycle cultivation
  5. Enhancing the production of gamma-linolenic acid in Hansenula polymorpha by fed-batch fermentation using response surface methodology
  6. Process characteristics for a gas—liquid system agitated in a vessel equipped with a turbine impeller and tubular baffles
  7. Kinetic study of pyrolysis of waste water treatment plant sludge
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  16. Carnauba wax microparticles produced by melt dispersion technique
  17. Complexation studies of 3-substituted β-diketones with selected d- and f-metal ions
  18. Influence of the solvent donor number on the O/W partition ratio of Cu(II) complexes of 1,2-dialkylimidazoles
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https://doi.org/10.2478/s11696-010-0097-4
Keywords for this article
polyunsaturated fatty acids; oleaginous fungi; fatty acid desaturation; lipid accumulation; gene expression

Articles in the same Issue

  1. Mechanisms controlling lipid accumulation and polyunsaturated fatty acid synthesis in oleaginous fungi
  2. Predicting retention indices of aliphatic hydrocarbons on stationary phases modified with metallocyclams using quantitative structure-retention relationships
  3. New SPME fibre for analysis of mequinol emitted from DVDs
  4. Continuous production of citric acid from raw glycerol by Yarrowia lipolytica in cell recycle cultivation
  5. Enhancing the production of gamma-linolenic acid in Hansenula polymorpha by fed-batch fermentation using response surface methodology
  6. Process characteristics for a gas—liquid system agitated in a vessel equipped with a turbine impeller and tubular baffles
  7. Kinetic study of pyrolysis of waste water treatment plant sludge
  8. Transport phenomena in an agitated vessel with an eccentrically located impeller
  9. Membrane extraction of 1-phenylethanol from fermentation solution
  10. Theoretical study on transesterification in a combined process consisting of a reactive distillation column and a pervaporation unit
  11. Wall effects on terminal falling velocity of spherical particles moving in a Carreau model fluid
  12. The effect of the physical properties of the liquid phase on the gas-liquid mass transfer coefficient in two- and three-phase agitated systems
  13. Effectiveness of nitric oxide ozonation
  14. Modelling of nanocrystalline iron nitriding process — influence of specific surface area
  15. Effect of CeO2 and Sb2O3 on the phase transformation and optical properties of photostable titanium dioxide
  16. Carnauba wax microparticles produced by melt dispersion technique
  17. Complexation studies of 3-substituted β-diketones with selected d- and f-metal ions
  18. Influence of the solvent donor number on the O/W partition ratio of Cu(II) complexes of 1,2-dialkylimidazoles
  19. Continuous dialysis of sulphuric acid in the presence of zinc sulphate
  20. Differences in affinity of arylstilbazolium derivatives to tetraplex structures
  21. Fast ferritin immunoassay on PDMS microchips
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