COVID-19 vaccine-associated autoimmune disorders: Comments
-
Amnuay Kleebayoon
and
Viroj Wiwanitkit
To the Editor
We would like to comment on the article “Corona Virus Disease-19 Vaccine-associated Autoimmune Disorders”.[1] Awan et al. attempt to summarize the various autoimmune phenomena reported after corona virus disease 2019 (COVID-19) vaccination in order to sensitize the medical community so that they can better manage these diseases when confronted with them.[1] According to Awan et al., this review in no way negates the potential benefit of COVID-19 vaccination, which has cemented its place in preventing infections and significantly reducing severity and mortality.[1]
The relationship might not be exactly as it is described in the report. The occurrence of adverse reactions following a COVID-19 vaccine presents an intriguing clinical quandary. Articles may provide case-specific data, but it is impossible to know with precision how confounding variables affect outcomes. It could be difficult to decide which course of action is best. Examining the effects of COVID-19 vaccination aversion, which appears to be quite idiosyncratic, is the goal of the current study. Due to a lack of clinical data characterizing the physiological and immunological status of COVID-19 vaccine recipients before to vaccine injection, it could be difficult to pinpoint the exact cause of a vaccination reaction. It can be difficult to demonstrate the absence of a particular perplexing circumstance.
Comorbidities are rarely mentioned in clinical records, even when they do exist. Finding the specific patho-immunopharmacological relationship might occasionally be challenging due to a lack of knowledge. Understanding how concurrent medical problems affect clinical outcomes can be challenging. The least significant is genetics.[2] When none of the study's conclusions can be supported by any existing evidence, obtaining further information is challenging. There may be a need for further investigation that considers additional factors.
Conflict of Interest
The authors declare no conflict of interest.
References
[1] Awan MH, Samreen S, Salim B, et al. Corona Virus Disease-19 Vaccine-associated Autoimmune Disorders. Rheumatol Immunol Res. 2022;3:111–119.Search in Google Scholar
[2] Čiučiulkaitė I, Möhlendick B, Thümmler L, et al. GNB3 c.825c>T polymorphism influences T-cell but not antibody response following vaccination with the mRNA-1273 vaccine. Front Genet. 2022;13:932043.Search in Google Scholar
© 2023 Amnuay Kleebayoon et al., published by De Gruyter
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Articles in the same Issue
- Editorial
- The challenge of ocular inflammation in systemic vasculitis: How to address inequalities of care?
- Review
- Animal models for large vessel vasculitis – The unmet need
- Pathogenesis of anti-neutrophil cytoplasmic antibody-associated vasculitis
- Original Article
- Clinical and vascular features of stroke in Takayasu's arteritis: A 24-year retrospective study
- Development and internal validation of a model to predict long-term survival of ANCA associated vasculitis
- Case Report
- Intermittent fever and cough in a 56-year-old patient: Relapsing polychondritis and extranodal NK/T-cell lymphoma
- Images
- Unusual presentation of a mass and “cobble-stone like” changes in the bronchus of a patient with granulomatosis with polyangitis
- Letter to the Editor
- COVID-19 vaccine-associated autoimmune disorders: Comments
