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Mechanism of the Hepatoprotective Activities of the Garcinia Hydroxybiflavanonol, GB1
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Ifeanyi I Madubunyi
Published/Copyright:
December 27, 2010
Garcinia kola Heckel (Guttiferae) known as “Aki-ilu” (meaning bitter kola) is a large economic tree indigenous to southern part of Nigeria. Its seeds have been of interest to researchers because of its use in the treatment of various disease conditions in Nigerian traditional medicine. The influence of the Garcinia hydroxybiflavanonol, GB1 on the membrane of primary cultured rat hepatocytes was studied. This work provides the first concrete evidence on the membrane stabilizing action of the hepatoprotective principle of Garcinia kola nuts. Results demonstrated that at high concentrations, the Garcinia hydroxybiflavanonol, GB1 as well as silibinin interact very strongly with the protein components of the liver cell membrane thereby causing an unspecific inhibition of the different transport systems in the membrane. These findings demonstrate that the hepatoprotective activity of the Garcinia hydroxybiflavanonols could be explained, at least in part, by their ability to stabilize the membrane of hepatocytes. This stabilizing effect may find a beneficial application in the therapy of various hepatic disorders especially those involving abnormal fragility of the hepatocyte membrane.
Keywords: Garcinia kola; hydroxybiflavanonol; hepatocytes; Alexander cells; liposomes; membrane stabilization
Published Online: 2010-12-27
©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston
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Keywords for this article
Garcinia kola;
hydroxybiflavanonol;
hepatocytes;
Alexander cells;
liposomes;
membrane stabilization
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